Mechanical forces direct stem cell behaviour in development and regeneration

The Effect of Uniaxial Mechanical Stretch on Wnt/β-Catenin Pathway in Bone Mesenchymal Stem Cells

(2017) Chuang Zhao et al.   JOURNAL OF CRANIOFACIAL SURGERY

Multiscale force sensing in development

(2017) Nicoletta I. Petridou et al.   NATURE CELL BIOLOGY

Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin

(2017) Amy E. Shyer et al.   SCIENCE

Photothermally triggered actuation of hybrid materials as a new platform for in vitro cell manipulation

(2017) Amy Sutton et al.   Nature Communications

A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction

(2017) Mufeng Hu et al.   Scientific Reports

Versatile synthetic alternatives to Matrigel for vascular toxicity screening and stem cell expansion

(2017) Eric H. Nguyen et al.   Nature Biomedical Engineering

Soft Material Approach to Induce Oxidative Stress in Mesenchymal Stem Cells for Functional Tissue Repair

(2016) Haibo Yang et al.   ACS Applied Materials & Interfaces

Directed Assembly and Development of Material-Free Tissues with Complex Architectures

(2016) Erik Vrij et al.   ADVANCED MATERIALS

Rotation-based technique for the rapid densification of tubular collagen gel scaffolds

(2016) Caroline Loy et al.   Biotechnology Journal

Importance of environmental stiffness for megakaryocyte differentiation and proplatelet formation

(2016) A. Aguilar et al.   BLOOD

Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism

(2016) Julia C. Chen et al.   FASEB JOURNAL

Asymmetric division of contractile domains couples cell positioning and fate specification

(2016) Jean-Léon Maître et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

(2016) Shinuo Weng et al.   NATURE MATERIALS

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery

(2016) Angelo S. Mao et al.   NATURE MATERIALS

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Defined three-dimensional microenvironments boost induction of pluripotency

(2016) Massimiliano Caiazzo et al.   NATURE MATERIALS

Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche

(2016) Yue Shao et al.   NATURE MATERIALS

Spatially patterned matrix elasticity directs stem cell fate

(2016) Chun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biologic-free mechanically induced muscle regeneration

(2016) Christine A. Cezar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels

(2016) Sungmin Nam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias

(2016) Jae-Won Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Substrate Stress-Relaxation Regulates Scaffold Remodeling and Bone Formation In Vivo

(2016) Max Darnell et al.   Advanced Healthcare Materials

Rotation-based technique for the rapid densification of tubular collagen gel scaffolds

(2016) Caroline Loy et al.   Biotechnology Journal

Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on BMD Among Young Childhood Cancer Survivors

(2016) Rona J. Mogil et al.   JAMA Oncology

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

(2015) Adam D. Celiz et al.   ADVANCED MATERIALS

Mechanoresponsive, omni-directional and local matrix-degrading actin protrusions in human mesenchymal stem cells microencapsulated in a 3D collagen matrix

(2015) Fu Chak Ho et al.   BIOMATERIALS

The effects of electrospun substrate-mediated cell colony morphology on the self-renewal of human induced pluripotent stem cells

(2015) Maricela Maldonado et al.   BIOMATERIALS

Mechanics of intact bone marrow

(2015) Lauren E. Jansen et al.   Journal of the Mechanical Behavior of Biomedical Materials

Matrix Stiffness and Nanoscale Spatial Organization of Cell-Adhesive Ligands Direct Stem Cell Fate

(2015) Kai Ye et al.   NANO LETTERS

Design, fabrication and control of soft robots

(2015) Daniela Rus et al.   NATURE

Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature

(2015) Hunter Elliott et al.   NATURE CELL BIOLOGY

Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation

(2015) Nathaniel Huebsch et al.   NATURE MATERIALS

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels

(2015) Rajat K. Das et al.   NATURE MATERIALS

Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks

(2015) Donald R. Griffin et al.   NATURE MATERIALS

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Tissue matrix arrays for high-throughput screening and systems analysis of cell function

(2015) Vince Z Beachley et al.   NATURE METHODS

A synthetic hydrogel for the high-throughput study of cell–ECM interactions

(2015) Andrew D. Rape et al.   Nature Communications

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

A structure-based extracellular matrix expansion mechanism of fibrous tissue growth

(2015) Nicholas S Kalson et al.   eLife

Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

(2015) Yfat Yahalom-Ronen et al.   eLife

Down-regulation of adipogenesis of mesenchymal stem cells by oscillating high-gradient magnetic fields and mechanical vibration

(2014) V. Zablotskii et al.   APPLIED PHYSICS LETTERS

Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography

(2014) Dongyuan Lü et al.   BIOMATERIALS

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Inelastic behaviour of collagen networks in cell-matrix interactions and mechanosensation

(2014) H. Mohammadi et al.   Journal of the Royal Society Interface

Auxetic nuclei in embryonic stem cells exiting pluripotency

(2014) Stefano Pagliara et al.   NATURE MATERIALS

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

(2014) Yubing Sun et al.   NATURE MATERIALS

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

High-throughput optical screening of cellular mechanotransduction

(2014) Jonathan L. Compton et al.   Nature Photonics

Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

(2014) Medha M. Pathak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling cell–cell interactions using surface acoustic waves

(2014) Feng Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Mechanical unloading of bone in microgravity reduces mesenchymal and hematopoietic stem cell-mediated tissue regeneration

(2014) E.A. Blaber et al.   Stem Cell Research

Mesenchymal morphogenesis of embryonic stem cells dynamically modulates the biophysical microtissue niche

(2014) Melissa A. Kinney et al.   Scientific Reports

Injectable MMP-Sensitive Alginate Hydrogels as hMSC Delivery Systems

(2013) Keila B. Fonseca et al.   BIOMACROMOLECULES

Contractile Forces Sustain and Polarize Hematopoiesis from Stem and Progenitor Cells

(2013) Jae-Won Shin et al.   Cell Stem Cell

Spatial organization within a niche as a determinant of stem-cell fate

(2013) Panteleimon Rompolas et al.   NATURE

Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels

(2013) Sudhir Khetan et al.   NATURE MATERIALS

Tightly anchored tissue-mimetic matrices as instructive stem cell microenvironments

(2013) Marina C Prewitz et al.   NATURE METHODS

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Mechanics of cranial sutures during simulated cyclic loading

(2012) S.C. Jasinoski et al.   JOURNAL OF BIOMECHANICS

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

(2012) Matthew Raab et al.   JOURNAL OF CELL BIOLOGY

Extracellular-matrix tethering regulates stem-cell fate

(2012) Britta Trappmann et al.   NATURE MATERIALS

Magnetic nanoparticle–mediated massively parallel mechanical modulation of single-cell behavior

(2012) Peter Tseng et al.   NATURE METHODS

Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness

(2012) L. Trichet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrodynamic stretching of single cells for large population mechanical phenotyping

(2012) D. R. Gossett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage

(2012) J. D. Crane et al.   Science Translational Medicine

Primary Cilia-Mediated Mechanotransduction in Human Mesenchymal Stem Cells

(2012) David A. Hoey et al.   STEM CELLS

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

The influence of scaffold elasticity on germ layer specification of human embryonic stem cells

(2011) Janet Zoldan et al.   BIOMATERIALS

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

A focal adhesion protein-based mechanochemical checkpoint regulates cleft progression during branching morphogenesis

(2011) William P. Daley et al.   DEVELOPMENTAL DYNAMICS

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency

(2011) Rebecca J. McMurray et al.   NATURE MATERIALS

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

Stress-relaxation behavior in gels with ionic and covalent crosslinks

(2010) Xuanhe Zhao et al.   JOURNAL OF APPLIED PHYSICS

Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells

(2010) Jeff Holst et al.   NATURE BIOTECHNOLOGY

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

(2010) John T. Connelly et al.   NATURE CELL BIOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Mechanical regulation of cell function with geometrically modulated elastomeric substrates

(2010) Jianping Fu et al.   NATURE METHODS

Geometric cues for directing the differentiation of mesenchymal stem cells

(2010) K. A. Kilian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate Elasticity Regulates Skeletal Muscle Stem Cell Self-Renewal in Culture

(2010) P. M. Gilbert et al.   SCIENCE

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Matrix elasticity regulates the secretory profile of human bone marrow-derived multipotent mesenchymal stromal cells (MSCs)

(2009) F. Philipp Seib et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hematopoietic Stem Cell Development Is Dependent on Blood Flow

(2009) Trista E. North et al.   CELL

Pulsed Forces Timed by a Ratchet-like Mechanism Drive Directed Tissue Movement during Dorsal Closure

(2009) Jerome Solon et al.   CELL

Local Cortical Tension by Myosin II Guides 3D Endothelial Cell Branching

(2009) Robert S. Fischer et al.   CURRENT BIOLOGY

Identification of a mechanochemical checkpoint and negative feedback loop regulating branching morphogenesis

(2009) William P. Daley et al.   DEVELOPMENTAL BIOLOGY

Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate

(2009) Joy Kahn et al.   DEVELOPMENTAL CELL

Myosin II Dynamics Are Regulated by Tension in Intercalating Cells

(2009) Rodrigo Fernandez-Gonzalez et al.   DEVELOPMENTAL CELL

Early fracture callus displays smooth muscle-like viscoelastic properties ex vivo: Implications for fracture healing

(2009) Stuart J. McDonald et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Biomechanical forces promote embryonic haematopoiesis

(2009) Luigi Adamo et al.   NATURE

A mechanosensitive transcriptional mechanism that controls angiogenesis

(2009) Akiko Mammoto et al.   NATURE

Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells

(2009) Farhan Chowdhury et al.   NATURE MATERIALS

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Differential Interactions of FGFs with Heparan Sulfate Control Gradient Formation and Branching Morphogenesis

(2009) H. P. Makarenkova et al.   Science Signaling

Mechanical Signals Trigger Myosin II Redistribution and Mesoderm Invagination in Drosophila Embryos

(2009) P.-A. Pouille et al.   Science Signaling

Substrate Modulus Directs Neural Stem Cell Behavior

(2008) Krishanu Saha et al.   BIOPHYSICAL JOURNAL

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia

(2008) Jordi Alcaraz et al.   EMBO JOURNAL

Pulsed contractions of an actin–myosin network drive apical constriction

(2008) Adam C. Martin et al.   NATURE

Tensile forces govern germ-layer organization in zebrafish

(2008) M. Krieg et al.   NATURE CELL BIOLOGY

Nature and anisotropy of cortical forces orienting Drosophila tissue morphogenesis

(2008) Matteo Rauzi et al.   NATURE CELL BIOLOGY

Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells

(2008) Danielle S. W. Benoit et al.   NATURE MATERIALS

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyclic Mechanical Preconditioning Improves Engineered Muscle Contraction

(2008) Du Geon Moon et al.   TISSUE ENGINEERING PART A

A dynamic pattern of mechanical stimulation promotes ossification in avian embryonic long bones

(2007) Niamh C. Nowlan et al.   JOURNAL OF BIOMECHANICS

In vivo measurements of the elastic mechanical properties of human skin by indentation tests

(2007) C. Pailler-Mattei et al.   MEDICAL ENGINEERING & PHYSICS