The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology
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Title
The Role of Protein Engineering in Biomedical Applications of Mammalian Synthetic Biology
Authors
Keywords
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Journal
Small
Volume -, Issue -, Pages 1903093
Publisher
Wiley
Online
2019-10-07
DOI
10.1002/smll.201903093
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Note: Only part of the references are listed.- De novo design of potent and selective mimics of IL-2 and IL-15
- (2019) Daniel-Adriano Silva et al. NATURE
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- (2019) Michael B. Yaffe Science Signaling
- A chemical approach for global protein knockdown from mice to non-human primates
- (2019) Xiuyun Sun et al. Cell Discovery
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- (2019) Corentin Léger et al. Scientific Reports
- A CRISPR/Cas9-based central processing unit to program complex logic computation in human cells
- (2019) Hyojin Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins
- (2019) Nadine Eliane Schmit et al. ACS Chemical Biology
- Time-resolved protein activation by proximal decaging in living systems
- (2019) Jie Wang et al. NATURE
- Rewiring bacterial two-component systems by modular DNA-binding domain swapping
- (2019) Sebastian R. Schmidl et al. Nature Chemical Biology
- Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus
- (2019) Rebekah M. Dedrick et al. NATURE MEDICINE
- Machine learning-assisted directed protein evolution with combinatorial libraries
- (2019) Zachary Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complex signal processing in synthetic gene circuits using cooperative regulatory assemblies
- (2019) Caleb J. Bashor et al. SCIENCE
- A compact synthetic pathway rewires cancer signaling to therapeutic effector release
- (2019) Hokyung K. Chung et al. SCIENCE
- De novo design of tunable, pH-driven conformational changes
- (2019) Scott E. Boyken et al. SCIENCE
- End-to-End Differentiable Learning of Protein Structure
- (2019) Mohammed AlQuraishi Cell Systems
- Machine-learning-guided directed evolution for protein engineering
- (2019) Kevin K. Yang et al. NATURE METHODS
- Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response
- (2019) Patrick A. Baeuerle et al. Nature Communications
- A modular degron library for synthetic circuits in mammalian cells
- (2019) Hélène Chassin et al. Nature Communications
- From synthetic biology to human therapy: engineered mammalian cells
- (2019) Leo Scheller et al. CURRENT OPINION IN BIOTECHNOLOGY
- Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System
- (2019) Andrea Martella et al. ACS Synthetic Biology
- Genetic circuitry for personalized human cell therapy
- (2019) Fabian Tolle et al. CURRENT OPINION IN BIOTECHNOLOGY
- Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
- (2018) Jang Hwan Cho et al. CELL
- Immunomimetic Designer Cells Protect Mice from MRSA Infection
- (2018) Ying Liu et al. CELL
- Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity
- (2018) Ye Li et al. Cell Stem Cell
- Directed Evolution of a Picomolar Affinity High Specificity Antibody Targeting Phosphorylated Tau
- (2018) Dan Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Generalized extracellular molecule sensor platform for programming cellular behavior
- (2018) Leo Scheller et al. Nature Chemical Biology
- An enhanced CRISPR repressor for targeted mammalian gene regulation
- (2018) Nan Cher Yeo et al. NATURE METHODS
- StaPLs: versatile genetically encoded modules for engineering drug-inducible proteins
- (2018) Conor L. Jacobs et al. NATURE METHODS
- The challenges facing synthetic biology in eukaryotes
- (2018) Francesca Ceroni et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Computational design of orthogonal membrane receptor-effector switches for rewiring signaling pathways
- (2018) M. Young et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthetic biology-based cellular biomedical tattoo for detection of hypercalcemia associated with cancer
- (2018) Aizhan Tastanova et al. Science Translational Medicine
- Caffeine-inducible gene switches controlling experimental diabetes
- (2018) Daniel Bojar et al. Nature Communications
- Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment
- (2018) Ryosuke Kojima et al. Nature Communications
- A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell
- (2018) Yasunori Okamoto et al. Nature Communications
- Engineering Whole Mammalian Cells for Target-Cell-Specific Invasion/Fusion
- (2018) Ryosuke Kojima et al. Advanced Science
- Programming mammalian gene expression with the antibiotic simocyclinone D8 and the flavonoid luteolin
- (2018) Daniel Bojar et al. AICHE JOURNAL
- Programmable protein circuits in living cells
- (2018) Xiaojing J. Gao et al. SCIENCE
- De novo coiled-coil peptides as scaffolds for disrupting protein–protein interactions
- (2018) Jordan M. Fletcher et al. Chemical Science
- Design of metalloproteins and novel protein folds using variational autoencoders
- (2018) Joe G. Greener et al. Scientific Reports
- Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells
- (2018) Julia Baaske et al. Scientific Reports
- Programmable design of orthogonal protein heterodimers
- (2018) Zibo Chen et al. NATURE
- Design of fast proteolysis-based signaling and logic circuits in mammalian cells
- (2018) Tina Fink et al. Nature Chemical Biology
- Engineered anti-CRISPR proteins for optogenetic control of CRISPR–Cas9
- (2018) Felix Bubeck et al. NATURE METHODS
- Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory
- (2018) Sophie Viaud et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Engineering allosteric regulation in protein kinases
- (2018) David Pincus et al. Science Signaling
- Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells
- (2018) Federica Cella et al. Nature Communications
- Synthetic RNA-based logic computation in mammalian cells
- (2018) Satoshi Matsuura et al. Nature Communications
- Optogenetic Medicine: Synthetic Therapeutic Solutions Precision-Guided by Light
- (2018) Haifeng Ye et al. Cold Spring Harbor Perspectives in Medicine
- Two-Dimensional Regulation of CAR-T Therapy with Orthogonal Switches
- (2018) MyLinh T. Duong et al. Molecular Therapy-Oncolytics
- Purity by design: Reducing impurities in bioproduction by stimulus-controlled global translational downregulation of non-product proteins
- (2018) Daniel Bojar et al. METABOLIC ENGINEERING
- Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network
- (2017) Pratik Saxena et al. JOURNAL OF BIOTECHNOLOGY
- Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer
- (2017) Somala Mohammed et al. MOLECULAR THERAPY
- Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells
- (2017) Benjamin H Weinberg et al. NATURE BIOTECHNOLOGY
- Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation
- (2017) Ryosuke Kojima et al. Nature Chemical Biology
- Programmable full-adder computations in communicating three-dimensional cell cultures
- (2017) David Ausländer et al. NATURE METHODS
- The directed evolution of ligand specificity in a GPCR and the unequal contributions of efficacy and affinity
- (2017) Raphaël B. Di Roberto et al. Scientific Reports
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- (2016) Leonardo Morsut et al. CELL
- Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors
- (2016) Kole T. Roybal et al. CELL
- Overexpression of YY1 increases the protein production in mammalian cells
- (2016) Aizhan Tastanova et al. JOURNAL OF BIOTECHNOLOGY
- Mammalian synthetic biology for studying the cell
- (2016) Melina Mathur et al. JOURNAL OF CELL BIOLOGY
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- (2016) Kelly A Schwarz et al. Nature Chemical Biology
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- (2016) Alejandro Chavez et al. NATURE METHODS
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- (2016) S. B. Jennifer Kan et al. SCIENCE
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- (2016) Jessica K. Polka et al. Cold Spring Harbor Perspectives in Biology
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- (2016) Pratik Saxena et al. Nature Communications
- CAR models: next-generation CAR modifications for enhanced T-cell function
- (2016) Daniel Abate-Daga et al. Molecular Therapy-Oncolytics
- Toxicity and management in CAR T-cell therapy
- (2016) Challice L Bonifant et al. Molecular Therapy-Oncolytics
- A light-inducible CRISPR-Cas9 system for control of endogenous gene activation
- (2015) Lauren R Polstein et al. Nature Chemical Biology
- Continuous directed evolution of DNA-binding proteins to improve TALEN specificity
- (2015) Basil P Hubbard et al. NATURE METHODS
- Engineering an allosteric transcription factor to respond to new ligands
- (2015) Noah D Taylor et al. NATURE METHODS
- T cell engineering as therapy for cancer and HIV: our synthetic future
- (2015) Carl H. June et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Remote control of therapeutic T cells through a small molecule-gated chimeric receptor
- (2015) C.-Y. Wu et al. SCIENCE
- A Synthetic Multifunctional Mammalian pH Sensor and CO2 Transgene-Control Device
- (2014) David Ausländer et al. MOLECULAR CELL
- Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
- (2014) N. Preiswerk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion
- (2013) Valérie Le Fourn et al. METABOLIC ENGINEERING
- Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
- (2013) Stephan A. Grupp et al. NEW ENGLAND JOURNAL OF MEDICINE
- A De Novo Protein Binding Pair By Computational Design and Directed Evolution
- (2011) John Karanicolas et al. MOLECULAR CELL
- The N-end rule pathway and regulation by proteolysis
- (2011) Alexander Varshavsky PROTEIN SCIENCE
- Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin
- (2009) M. Gitzinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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