Engineering protein-protein devices for multilayered regulation of mRNA translation using orthogonal proteases in mammalian cells

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Programming gene and engineered-cell therapies with synthetic biology

(2018) Tasuku Kitada et al.   SCIENCE

Engineering modular intracellular protein sensor-actuator devices

(2018) Velia Siciliano et al.   Nature Communications

SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop

(2017) Chun-Ping Cui et al.   GUT

Rewiring human cellular input–output using modular extracellular sensors

(2016) Kelly A Schwarz et al.   Nature Chemical Biology

Post-translational control of genetic circuits usingPotyvirusproteases

(2016) Jesus Fernandez-Rodriguez et al.   NUCLEIC ACIDS RESEARCH

SENP1 regulates cell migration and invasion in neuroblastoma

(2015) Yan Xiang-ming et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

RNA aptamers as genetic control devices: The potential of riboswitches as synthetic elements for regulating gene expression

(2015) Christian Berens et al.   Biotechnology Journal

Mammalian synthetic biology: emerging medical applications

(2015) Z. Kis et al.   Journal of the Royal Society Interface

Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery

(2015) Liliana Wroblewska et al.   NATURE BIOTECHNOLOGY

Tunable and reversible drug control of protein production via a self-excising degron

(2015) Hokyung K Chung et al.   Nature Chemical Biology

RNA aptamers as genetic control devices: The potential of riboswitches as synthetic elements for regulating gene expression

(2015) Christian Berens et al.   Biotechnology Journal

RNA-Based Vaccines in Cancer Immunotherapy

(2015) Megan A. McNamara et al.   Journal of Immunology Research

Engineered UV-A light-responsive gene expression system for measuring sun cream efficacy in mammalian cell culture

(2014) Markus Wieland et al.   JOURNAL OF BIOTECHNOLOGY

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Synthetic biology in mammalian cells: next generation research tools and therapeutics

(2014) Florian Lienert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SUMO-specific protease 1 regulates pancreatic cancer cell proliferation and invasion by targeting MMP-9

(2014) Chenchao Ma et al.   TUMOR BIOLOGY

Model-Driven Engineering of Gene Expression from RNA Replicons

(2014) Jacob Beal et al.   ACS Synthetic Biology

Efficient Generation of Human iPSCs by a Synthetic Self-Replicative RNA

(2013) Naohisa Yoshioka et al.   Cell Stem Cell

Small-molecule displacement of a cryptic degron causes conditional protein degradation

(2011) Kimberly M Bonger et al.   Nature Chemical Biology

Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

(2011) Z. Xie et al.   SCIENCE

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

(2010) Daniel C. Gray et al.   CELL

mRNA as gene therapeutic: How to control protein expression

(2010) Geertrui Tavernier et al.   JOURNAL OF CONTROLLED RELEASE

Strategies for protein synthetic biology

(2010) Raik Grünberg et al.   NUCLEIC ACIDS RESEARCH

Reengineering orthogonally selective riboswitches

(2010) N. Dixon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming Cellular Behavior with RNA Controllers Responsive to Endogenous Proteins

(2010) S. J. Culler et al.   SCIENCE

Synthetic translational regulation by an L7Ae–kink-turn RNP switch

(2009) Hirohide Saito et al.   Nature Chemical Biology

Protein design in biological networks: from manipulating the input to modifying the output

(2009) A. M. Van der Sloot et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Direct selection for ribozyme cleavage activity in cells

(2009) X. Chen et al.   RNA

Cell-Type-Specific TEV Protease Cleavage Reveals Cohesin Functions in Drosophila Neurons

(2008) Andrea Pauli et al.   DEVELOPMENTAL CELL

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Designed Armadillo Repeat Proteins as General Peptide-Binding Scaffolds: Consensus Design and Computational Optimization of the Hydrophobic Core

(2008) Fabio Parmeggiani et al.   JOURNAL OF MOLECULAR BIOLOGY

Chemical control of protein stability and function in living mice

(2008) Laura A Banaszynski et al.   NATURE MEDICINE