Generalized extracellular molecule sensor platform for programming cellular behavior

Sensing with modular receptors

(2017) Matthew Brenner et al.   Nature Chemical Biology

Nonimmune cells equipped with T-cell-receptor-like signaling for cancer cell ablation

(2017) Ryosuke Kojima et al.   Nature Chemical Biology

A Phytochrome Sensory Domain Permits Receptor Activation by Red Light

(2016) Eva Reichhart et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Prostate cancer

(2016) Gerhardt Attard et al.   LANCET

Rewiring human cellular input–output using modular extracellular sensors

(2016) Kelly A Schwarz et al.   Nature Chemical Biology

Synthetic gene network restoring endogenous pituitary–thyroid feedback control in experimental Graves’ disease

(2016) Pratik Saxena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunogenomic engineering of a plug-and-(dis)play hybridoma platform

(2016) Mark Pogson et al.   Nature Communications

VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis

(2016) Chandran S. Abhinand et al.   Journal of Cell Communication and Signaling

Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis

(2015) Lina Schukur et al.   Science Translational Medicine

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

A Protein-Tagging System for Signal Amplification in Gene Expression and Fluorescence Imaging

(2014) Marvin E. Tanenbaum et al.   CELL

The Basic Principles of Chimeric Antigen Receptor Design

(2013) Michel Sadelain et al.   Cancer Discovery

Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate

(2012) Mary P. Hall et al.   ACS Chemical Biology

Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome

(2012) H. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of mammalian cell membrane proteins

(2012) Masahiro Kawahara et al.   Current Opinion in Chemical Engineering

Crystal Structure of Human Prostate-Specific Antigen in a Sandwich Antibody Complex

(2011) Enrico A. Stura et al.   JOURNAL OF MOLECULAR BIOLOGY

Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody

(2011) Kaspars Tars et al.   JOURNAL OF MOLECULAR BIOLOGY

gp130 at the nexus of inflammation, autoimmunity, and cancer

(2010) J. S. Silver et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Allosteric Activation Mechanism of the Mycobacterium tuberculosis Receptor Ser/Thr Protein Kinase, PknB

(2010) T. Noelle Lombana et al.   STRUCTURE

Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency

(2008) Wenhai Liu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Crystal Structure of a Ternary Complex between Human Prostate-specific Antigen, Its Substrate Acyl Intermediate and an Activating Antibody

(2007) Renée Ménez et al.   JOURNAL OF MOLECULAR BIOLOGY