Programming mammalian gene expression with the antibiotic simocyclinone D8 and the flavonoid luteolin

Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network

(2017) Pratik Saxena et al.   JOURNAL OF BIOTECHNOLOGY

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

(2017) Benjamin H Weinberg et al.   NATURE BIOTECHNOLOGY

Programmable full-adder computations in communicating three-dimensional cell cultures

(2017) David Ausländer et al.   NATURE METHODS

The best of both worlds: reaping the benefits from mammalian and bacterial therapeutic circuits

(2016) Daniel Bojar et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Overexpression of YY1 increases the protein production in mammalian cells

(2016) Aizhan Tastanova et al.   JOURNAL OF BIOTECHNOLOGY

 -cell-mimetic designer cells provide closed-loop glycemic control

(2016) M. Xie et al.   SCIENCE

A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells

(2016) Pratik Saxena et al.   Nature Communications

Advanced Development Strategies for Biopharmaceutical Cell Culture Processes

(2015) Denes Zalai et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Cosmetics-triggered percutaneous remote control of transgene expression in mice

(2015) Hui Wang et al.   NUCLEIC ACIDS RESEARCH

Implantable synthetic cytokine converter cells with AND-gate logic treat experimental psoriasis

(2015) Lina Schukur et al.   Science Translational Medicine

TheSinorhizobium melilotiEmrAB Efflux System Is Regulated by Flavonoids Through a TetR-Like Regulator (EmrR)

(2013) Silvia Rossbach et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Programmable single-cell mammalian biocomputers

(2012) Simon Ausländer et al.   NATURE

From gene switches to mammalian designer cells: present and future prospects

(2012) Simon Ausländer et al.   TRENDS IN BIOTECHNOLOGY

Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors

(2011) Maria De Jesus et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The food additive vanillic acid controls transgene expression in mammalian cells and mice

(2011) Marc Gitzinger et al.   NUCLEIC ACIDS RESEARCH

Synthetic Biology Moving into the Clinic

(2011) W. C. Ruder et al.   SCIENCE

A designer network coordinating bovine artificial insemination by ovulation-triggered release of implanted sperms

(2010) Christian Kemmer et al.   JOURNAL OF CONTROLLED RELEASE

A biotin-triggered genetic switch in mammalian cells and mice

(2009) Wilfried Weber et al.   METABOLIC ENGINEERING

Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone inStreptomyces antibioticus

(2009) Tung B. K. Le et al.   MOLECULAR MICROBIOLOGY

Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin

(2009) M. Gitzinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

Intronically encoded siRNAs improve dynamic range of mammalian gene regulation systems and toggle switch

(2008) D. Greber et al.   NUCLEIC ACIDS RESEARCH