A compact synthetic pathway rewires cancer signaling to therapeutic effector release

Emerging functions of the EGFR in cancer

(2017) Sara Sigismund et al.   Molecular Oncology

A light- and calcium-gated transcription factor for imaging and manipulating activated neurons

(2017) Wenjing Wang et al.   NATURE BIOTECHNOLOGY

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

Genomic alterations of ERBB receptors in cancer: clinical implications

(2017) Rosalin Mishra et al.   Oncotarget

Review: Oncolytic virotherapy, updates and future directions

(2017) Christos Fountzilas et al.   Oncotarget

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Targeting the Gatekeeper: Osimertinib in EGFR T790M Mutation–Positive Non–Small Cell Lung Cancer

(2016) Ferdinandos Skoulidis et al.   CLINICAL CANCER RESEARCH

Comparison of toxicity profile and tolerability between two standard of care paclitaxel-based adjuvant chemotherapy regimens in breast cancer

(2016) Mohamed Alsharedi et al.   MEDICAL ONCOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Rewiring human cellular input–output using modular extracellular sensors

(2016) Kelly A Schwarz et al.   Nature Chemical Biology

Weekly vs. Every-3-Week Paclitaxel for Ovarian Cancer

(2016)   NEW ENGLAND JOURNAL OF MEDICINE

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

Quantification of Epidermal Growth Factor Receptor Expression Level and Binding Kinetics on Cell Surfaces by Surface Plasmon Resonance Imaging

(2015) Fenni Zhang et al.   ANALYTICAL CHEMISTRY

Molecular Pathways: Mechanism of Action for Talimogene Laherparepvec, a New Oncolytic Virus Immunotherapy

(2015) F. J. Kohlhapp et al.   CLINICAL CANCER RESEARCH

ErbB-targeted CAR T-cell immunotherapy of cancer

(2015) Lynsey M Whilding et al.   Immunotherapy

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

Tunable and reversible drug control of protein production via a self-excising degron

(2015) Hokyung K Chung et al.   Nature Chemical Biology

Highly efficient Cas9-mediated transcriptional programming

(2015) Alejandro Chavez et al.   NATURE METHODS

Update on taxanes in the first-line treatment of advanced non-small-cell lung cancer

(2014) M.A. Socinski   Current Oncology

Synthetic therapeutic gene circuits in mammalian cells

(2014) Haifeng Ye et al.   FEBS LETTERS

Synthetic biology in mammalian cells: next generation research tools and therapeutics

(2014) Florian Lienert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological Epidermal Growth Factor Concentrations Activate High Affinity Receptors to Elicit Calcium Oscillations

(2014) Béatrice Marquèze-Pouey et al.   PLoS One

EGFR Phosphorylates Tumor-Derived EGFRvIII Driving STAT3/5 and Progression in Glioblastoma

(2013) Qi-Wen Fan et al.   CANCER CELL

Architecture and Membrane Interactions of the EGF Receptor

(2013) Anton Arkhipov et al.   CELL

DARPin-targeting of Measles Virus: Unique Bispecificity, Effective Oncolysis, and Enhanced Safety

(2013) Katrin Friedrich et al.   MOLECULAR THERAPY

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

(2013) Yong Zheng et al.   NATURE

New viruses for cancer therapy: meeting clinical needs

(2013) Tanner S. Miest et al.   NATURE REVIEWS MICROBIOLOGY

EGFR and HER2 inhibition in pancreatic cancer

(2012) Naomi Walsh et al.   INVESTIGATIONAL NEW DRUGS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Fast rebinding increases dwell time of Src homology 2 (SH2)-containing proteins near the plasma membrane

(2012) D. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogene addiction as a foundational rationale for targeted anti-cancer therapy: promises and perils

(2011) Davide Torti et al.   EMBO Molecular Medicine

High Cleavage Efficiency of a 2A Peptide Derived from Porcine Teschovirus-1 in Human Cell Lines, Zebrafish and Mice

(2011) Jin Hee Kim et al.   PLoS One

Spatio-temporal modeling of signaling protein recruitment to EGFR

(2010) Ming-yu Hsieh et al.   BMC Systems Biology

Understanding and circumventing resistance to anticancer monoclonal antibodies

(2010) Lina Reslan et al.   mAbs

High-level expression by tissue/cancer-specific promoter with strict specificity using a single-adenoviral vector

(2010) Yumi Kanegae et al.   NUCLEIC ACIDS RESEARCH

Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis

(2009) Dominik E. Dorer et al.   ADVANCED DRUG DELIVERY REVIEWS

Characterization of increased drug metabolism activity in dimethyl sulfoxide (DMSO)-treated Huh7 hepatoma cells

(2009) S. Choi et al.   XENOBIOTICA