Programmable protein circuits in living cells

Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis

(2017) Josef A. Gramespacher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Large-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells

(2017) Benjamin H Weinberg et al.   NATURE BIOTECHNOLOGY

Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system

(2017) Nathan H. Kipniss et al.   Nature Communications

Ultrasensitive Scaffold-Dependent Protease Sensors with Large Dynamic Range

(2017) Viktor Stein et al.   ACS Synthetic Biology

Time-gated detection of protein-protein interactions with transcriptional readout

(2017) Min Woo Kim et al.   eLife

Toward a world of theranostic medication: Programming biological sentinel systems for therapeutic intervention

(2016) Ryosuke Kojima et al.   ADVANCED DRUG DELIVERY REVIEWS

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Post-translational control of genetic circuits usingPotyvirusproteases

(2016) Jesus Fernandez-Rodriguez et al.   NUCLEIC ACIDS RESEARCH

Dynamics of epigenetic regulation at the single-cell level

(2016) L. Bintu et al.   SCIENCE

Genetic circuit design automation

(2016) A. A. K. Nielsen et al.   SCIENCE

Synthetic recombinase-based state machines in living cells

(2016) N. Roquet et al.   SCIENCE

Synthetic Biology Platform for Sensing and Integrating Endogenous Transcriptional Inputs in Mammalian Cells

(2016) Bartolomeo Angelici et al.   Cell Reports

Mammalian synthetic circuits with RNA binding proteins for RNA-only delivery

(2015) Liliana Wroblewska et al.   NATURE BIOTECHNOLOGY

Tunable and reversible drug control of protein production via a self-excising degron

(2015) Hokyung K Chung et al.   Nature Chemical Biology

Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo

(2015) Tsz-Leung To et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drugging the undruggable RAS: Mission Possible?

(2014) Adrienne D. Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Synthetic biology in mammalian cells: next generation research tools and therapeutics

(2014) Florian Lienert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protease-based synthetic sensing and signal amplification

(2014) Viktor Stein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modular Extracellular Sensor Architecture for Engineering Mammalian Cell-based Devices

(2014) Nichole M. Daringer et al.   ACS Synthetic Biology

Chimeric Antigen Receptor Therapy for Cancer

(2013) David M. Barrett et al.   Annual Review of Medicine

The Utility of Paradoxical Components in Biological Circuits

(2013) Yuval Hart et al.   MOLECULAR CELL

An Improved Ras Sensor for Highly Sensitive and Quantitative FRET-FLIM Imaging

(2013) Ana F. Oliveira et al.   PLoS One

An Internal Ribosome Entry Site (IRES) Mutant Library for Tuning Expression Level of Multiple Genes in Mammalian Cells

(2013) Esther Y. C. Koh et al.   PLoS One

Amplifying Genetic Logic Gates

(2013) J. Bonnet et al.   SCIENCE

A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions

(2012) Ahmad S. Khalil et al.   CELL

Programmable single-cell mammalian biocomputers

(2012) Simon Ausländer et al.   NATURE

Oncolytic virotherapy

(2012) Stephen J Russell et al.   NATURE BIOTECHNOLOGY

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy

(2012) Margaret T Butko et al.   NATURE NEUROSCIENCE

A tunable zinc finger-based framework for Boolean logic computation in mammalian cells

(2012) Jason J. Lohmueller et al.   NUCLEIC ACIDS RESEARCH

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

An overview of enzymatic reagents for the removal of affinity tags

(2011) David S. Waugh   PROTEIN EXPRESSION AND PURIFICATION

Multi-Input RNAi-Based Logic Circuit for Identification of Specific Cancer Cells

(2011) Z. Xie et al.   SCIENCE

Activation of Specific Apoptotic Caspases with an Engineered Small-Molecule-Activated Protease

(2010) Daniel C. Gray et al.   CELL

A General Chemical Method to Regulate Protein Stability in the Mammalian Central Nervous System

(2010) Mari Iwamoto et al.   CHEMISTRY & BIOLOGY

The Bicoid Morphogen System

(2010) Aude Porcher et al.   CURRENT BIOLOGY

A tunable dual-promoter integrator for targeting of cancer cells

(2010) Lior Nissim et al.   Molecular Systems Biology

An engineered mammalian band-pass network

(2010) D. Greber et al.   NUCLEIC ACIDS RESEARCH

Defining Network Topologies that Can Achieve Biochemical Adaptation

(2009) Wenzhe Ma et al.   CELL

Efficient protein depletion by genetically controlled deprotection of a dormant N-degron

(2009) Christof Taxis et al.   Molecular Systems Biology

Computational design of synthetic gene circuits with composable parts

(2008) M.A. Marchisio et al.   BIOINFORMATICS

A fast, robust and tunable synthetic gene oscillator

(2008) Jesse Stricker et al.   NATURE