De novo design of potent and selective mimics of IL-2 and IL-15

Structures and disulfide cross-linking of de novo designed therapeutic mini-proteins

(2018) Daniel-Adriano Silva et al.   FEBS Journal

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes

(2018) Jonathan T. Sockolosky et al.   SCIENCE

Essentials of de novo protein design: Methods and applications

(2018) Enrique Marcos et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs

(2018) Michael Dougan et al.   Cancer Immunology Research

Reprogramming immune proteins as therapeutics using molecular engineering

(2018) Rakeeb Kureshi et al.   Current Opinion in Chemical Engineering

The potential and promise of IL-15 in immuno-oncogenic therapies

(2017) Tanya O. Robinson et al.   IMMUNOLOGY LETTERS

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells

(2017) Rodrigo Vazquez-Lombardi et al.   Nature Communications

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers

(2017) Ignacio Moraga et al.   eLife

NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

(2016) D. H. Charych et al.   CLINICAL CANCER RESEARCH

Interleukin-2-Dependent Allergen-Specific Tissue-Resident Memory Cells Drive Asthma

(2016) Brian D. Hondowicz et al.   IMMUNITY

Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy

(2016) Lingfeng Liu et al.   NATURE BIOTECHNOLOGY

A Randomized Trial of Factor VIII and Neutralizing Antibodies in Hemophilia A

(2016) Flora Peyvandi et al.   NEW ENGLAND JOURNAL OF MEDICINE

De novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificity

(2016) S. E. Boyken et al.   SCIENCE

Design of structurally distinct proteins using strategies inspired by evolution

(2016) T. M. Jacobs et al.   SCIENCE

Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

(2016) Stephanie Berger et al.   eLife

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

Synergistic Innate and Adaptive Immune Response to Combination Immunotherapy with Anti-Tumor Antigen Antibodies and Extended Serum Half-Life IL-2

(2015) Eric F. Zhu et al.   CANCER CELL

Antigen specificity can be irrelevant to immunocytokine efficacy and biodistribution

(2015) Alice Tzeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination therapy of an IL-15 superagonist complex, ALT-803, and a tumor targeting monoclonal antibody promotes direct antitumor activity and protective vaccinal effect in a syngenic mouse melanoma model

(2015) Xiaoyue Chen et al.   Journal for ImmunoTherapy of Cancer

A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells

(2014) Erik Procko et al.   CELL

Proof of principle for epitope-focused vaccine design

(2014) Bruno E. Correia et al.   NATURE

MICAN : a protein structure alignment algorithm that can handle Multiple-chains, Inverse alignments, Cα only models, Alternative alignments, and Non-sequential alignments

(2013) Shintaro Minami et al.   BMC BIOINFORMATICS

A flexible algorithm for calculating pair interactions on SIMD architectures

(2013) Szilárd Páll et al.   COMPUTER PHYSICS COMMUNICATIONS

Human IL-2 Mutein with Higher Antitumor Efficacy Than Wild Type IL-2

(2013) T. Carmenate et al.   JOURNAL OF IMMUNOLOGY

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Chemistry for peptide and protein PEGylation

(2012) M.J. Roberts et al.   ADVANCED DRUG DELIVERY REVIEWS

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

(2012) Aaron M Ring et al.   NATURE IMMUNOLOGY

Interleukins, from 1 to 37, and interferon-γ: Receptors, functions, and roles in diseases

(2011) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

(2011) Sarel J. Fleishman et al.   PLoS One

Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin

(2011) S. J. Fleishman et al.   SCIENCE

PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta

(2010) S. Chaudhury et al.   BIOINFORMATICS

Cython: The Best of Both Worlds

(2010) Stefan Behnel et al.   COMPUTING IN SCIENCE & ENGINEERING

An improved yeast transformation method for the generation of very large human antibody libraries

(2010) Lorenzo Benatuil et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Regulatory T cells and immune tolerance to tumors

(2009) Xuefang Cao   IMMUNOLOGIC RESEARCH

Optimizing Protein Stability In Vivo

(2009) Linda Foit et al.   MOLECULAR CELL

Immune Therapy for Cancer

(2008) Michael Dougan et al.   Annual Review of Immunology

DARPins: A new generation of protein therapeutics

(2008) Michael T. Stumpp et al.   DRUG DISCOVERY TODAY

The Exon-3-Encoded Domain of IL-15Rα Contributes to IL-15 High-Affinity Binding and Is Crucial for the IL-15 Antagonistic Effect of Soluble IL-15Rα

(2008) Grégory Bouchaud et al.   JOURNAL OF MOLECULAR BIOLOGY