Engineering allosteric regulation in protein kinases

Spatial and temporal signal processing and decision making by MAPK pathways

(2017) Oguzhan Atay et al.   JOURNAL OF CELL BIOLOGY

Engineering extrinsic disorder to control protein activity in living cells

(2016) Onur Dagliyan et al.   SCIENCE

Rapid construction of metabolite biosensors using domain-insertion profiling

(2016) Dana C. Nadler et al.   Nature Communications

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

Protein Sectors: Statistical Coupling Analysis versus Conservation

(2015) Tiberiu Teşileanu et al.   PLoS Computational Biology

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2

(2014) Alexandre Beautrait et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploitation of Latent Allostery Enables the Evolution of New Modes of MAP Kinase Regulation

(2013) Scott M. Coyle et al.   CELL

Rational design of a ligand-controlled protein conformational switch

(2013) O. Dagliyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational properties of amino acid residues: implications for evolvability of phosphorylatable residues

(2012) P. Creixell et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

A Mechanism for the Evolution of Phosphorylation Sites

(2011) Samuel M. Pearlman et al.   CELL

Hot Spots for Allosteric Regulation on Protein Surfaces

(2011) Kimberly A. Reynolds et al.   CELL

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

An interdomain sector mediating allostery in Hsp70 molecular chaperones

(2010) Robert G Smock et al.   Molecular Systems Biology

Reagents for investigating MAPK signalling in model yeast species

(2010) David Pincus et al.   YEAST

Protein Sectors: Evolutionary Units of Three-Dimensional Structure

(2009) Najeeb Halabi et al.   CELL

The Ste5 Scaffold Directs Mating Signaling by Catalytically Unlocking the Fus3 MAP Kinase for Activation

(2009) Matthew Good et al.   CELL

Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation

(2008) Panagis Filippakopoulos et al.   CELL

Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop Is Required for Interleukin (IL)-1-mediated Optimal NFκB and AP-1 Activation as Well as IL-6 Gene Expression

(2008) Yang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt-mediated phosphorylation of CDK2 regulates its dual role in cell cycle progression and apoptosis

(2008) S. Maddika et al.   JOURNAL OF CELL SCIENCE

The SWISS-MODEL Repository and associated resources

(2008) F. Kiefer et al.   NUCLEIC ACIDS RESEARCH

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress resistance and signal fidelity independent of nuclear MAPK function

(2008) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface Sites for Engineering Allosteric Control in Proteins

(2008) J. Lee et al.   SCIENCE