Death in the intestinal epithelium-basic biology and implications for inflammatory bowel disease

Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters

(2016) Paul W. Tetteh et al.   Cell Stem Cell

Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo

(2016) Chang Sup Lee et al.   IMMUNITY

Innate lymphoid cells in inflammatory bowel diseases

(2016) C.P. Peters et al.   IMMUNOLOGY LETTERS

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces

(2016) Chigusa Nakahashi-Oda et al.   NATURE IMMUNOLOGY

Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

(2016) M. R. Howitt et al.   SCIENCE

Loss of Response to Anti-TNFs: Definition, Epidemiology and Management

(2016) Giulia Roda et al.   Clinical and Translational Gastroenterology

Innate lymphoid cells: new insights into function and development

(2015) Victor S. Cortez et al.   CURRENT OPINION IN IMMUNOLOGY

Spreading the word: non-autonomous effects of apoptosis during development, regeneration and disease

(2015) Ainhoa Pérez-Garijo et al.   DEVELOPMENT

Death in the fast lane: what's next for necroptosis?

(2015) Andrew Oberst   FEBS Journal

Apoptotic cell recognition receptors and scavenger receptors

(2015) Kristen K. Penberthy et al.   IMMUNOLOGICAL REVIEWS

Apoptosis, Necrosis, and Necroptosis in the Gut and Intestinal Homeostasis

(2015) Anna Negroni et al.   MEDIATORS OF INFLAMMATION

A20 is a regulator of necroptosis

(2015) Prajwal Gurung et al.   NATURE IMMUNOLOGY

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

The unusual suspects—innate lymphoid cells as novel therapeutic targets in IBD

(2015) Rimma Goldberg et al.   Nature Reviews Gastroenterology & Hepatology

Guardians of the Gut – Murine Intestinal Macrophages and Dendritic Cells

(2015) Mor Gross et al.   Frontiers in Immunology

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Anatomical localization of commensal bacteria in immune cell homeostasis and disease

(2014) Thomas C. Fung et al.   IMMUNOLOGICAL REVIEWS

Intestinal IgA production and its role in host-microbe interaction

(2014) Cindy Gutzeit et al.   IMMUNOLOGICAL REVIEWS

Pleiotropic functions of TNF-  in the regulation of the intestinal epithelial response to inflammation

(2014) M. Leppkes et al.   INTERNATIONAL IMMUNOLOGY

Rate and Predictors of Mucosal Healing in Patients with Inflammatory Bowel Disease Treated with Anti-TNF-Alpha Antibodies

(2014) Florian Beigel et al.   PLoS One

Cell Death and Inflammatory Bowel Diseases: Apoptosis, Necrosis, and Autophagy in the Intestinal Epithelium

(2014) Tiago Nunes et al.   Biomed Research International

Review article: the role of anti-TNF in the management of ulcerative colitis - past, present and future

(2013) S. Danese et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Autophagy in Oncogenic K-Ras Promotes Basal Extrusion of Epithelial Cells by Degrading S1P

(2013) Gloria Slattum et al.   CURRENT BIOLOGY

Drug monitoring of biologics in inflammatory bowel disease

(2013) Alexander Eser et al.   CURRENT OPINION IN GASTROENTEROLOGY

New targets for mucosal healing and therapy in inflammatory bowel diseases

(2013) M F Neurath   Mucosal Immunology

TNF-α-induced intestinal epithelial cell shedding: implications for intestinal barrier function

(2012) Alastair J.M. Watson et al.   Annals of the New York Academy of Sciences

Innate immunity in the small intestine

(2012) Rebeca Santaolalla et al.   CURRENT OPINION IN GASTROENTEROLOGY

Development and function of intestinal innate lymphoid cells

(2012) M Cherrier et al.   CURRENT OPINION IN IMMUNOLOGY

Apoptosis, necrosis and necroptosis: cell death regulation in the intestinal epithelium

(2012) Claudia Günther et al.   GUT

Results of the 2nd scientific workshop of the ECCO (IV): Therapeutic strategies to enhance intestinal healing in inflammatory bowel disease

(2012) Alessandro Armuzzi et al.   Journal of Crohns & Colitis

Crohn's disease

(2012) Daniel C Baumgart et al.   LANCET

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia

(2012) George T. Eisenhoffer et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Homeland Security: IgA immunity at the frontiers of the body

(2012) Andrew J. Macpherson et al.   TRENDS IN IMMUNOLOGY

Review article: causative factors and the clinical management of patients with Crohn’s disease who lose response to anti-TNF-α therapy

(2011) S. Danese et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The intestinal microbiota in health and disease

(2011) Vincent B. Young   CURRENT OPINION IN GASTROENTEROLOGY

Modulation of immune homeostasis by commensal bacteria

(2011) Ivaylo I Ivanov et al.   CURRENT OPINION IN MICROBIOLOGY

Early Mucosal Healing With Infliximab Is Associated With Improved Long-term Clinical Outcomes in Ulcerative Colitis

(2011) Jean Frédéric Colombel et al.   GASTROENTEROLOGY

Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14+ Macrophages

(2011) Raja Atreya et al.   GASTROENTEROLOGY

Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease

(2011) R Kiesslich et al.   GUT

Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells

(2011) Thomas S. Griffith et al.   IMMUNITY

Epithelial cell extrusion requires the sphingosine-1-phosphate receptor 2 pathway

(2011) Yapeng Gu et al.   JOURNAL OF CELL BIOLOGY

Results from the 2nd Scientific Workshop of the ECCO (I): Impact of mucosal healing on the course of inflammatory bowel disease

(2011) Laurent Peyrin-Biroulet et al.   Journal of Crohns & Colitis

Results of the 2nd Scientific Workshop of the ECCO (III): Basic mechanisms of intestinal healing

(2011) Florian Rieder et al.   Journal of Crohns & Colitis

The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium

(2011) Thomas W. Marshall et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-κB pathways in intestinal epithelial cells

(2011) M E C Bruno et al.   Mucosal Immunology

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Ulcerative Colitis

(2011) Silvio Danese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intestinal microbiota: Shaping local and systemic immune responses

(2011) Michael J. Molloy et al.   SEMINARS IN IMMUNOLOGY

Intestinal epithelial cells and their role in innate mucosal immunity

(2010) A. L. Maldonado-Contreras et al.   CELL AND TISSUE RESEARCH

Cell death in the colonic epithelium during inflammatory bowel diseases

(2010) Lina Chen et al.   INFLAMMATORY BOWEL DISEASES

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions

(2009) Chen Varol et al.   IMMUNITY

Origin of the Lamina Propria Dendritic Cell Network

(2009) Milena Bogunovic et al.   IMMUNITY

Adalimumab safety in global clinical trials of patients with Crohnʼs disease

(2009) Jean-Frédéric Colombel et al.   INFLAMMATORY BOWEL DISEASES

Mucosal healing predicts long-term outcome of maintenance therapy with infliximab in Crohnʼs disease

(2009) Fabian Schnitzler et al.   INFLAMMATORY BOWEL DISEASES

P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium

(2009) Gloria Slattum et al.   JOURNAL OF CELL BIOLOGY

Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions

(2009) Olga Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Death receptor signal transducers: nodes of coordination in immune signaling networks

(2009) Nicholas S Wilson et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology