Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-α Treated Cell Monolayers

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment

(2016) Zhenyu Zhong et al.   CELL

Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles

(2016) E Fiacco et al.   CELL DEATH AND DIFFERENTIATION

Neutralization of IL-6 and TNF-α ameliorates intestinal permeability in DSS-induced colitis

(2016) Yong-Tao Xiao et al.   CYTOKINE

Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair

(2016) Anny-Claude Luissint et al.   GASTROENTEROLOGY

Increased autophagy is required to protect periodontal ligament stem cells from apoptosis in inflammatory microenvironment

(2016) Ying An et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Gastrointestinal mucosal barrier function and diseases

(2016) Tadayuki Oshima et al.   JOURNAL OF GASTROENTEROLOGY

TNF-α Blockade Efficiently Reduced Severe Intestinal Damage in Necrotizing Enterocolitis

(2016) Cuneyt Tayman et al.   JOURNAL OF INVESTIGATIVE SURGERY

Tumor necrosis factor-α induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions

(2015) Yasaman Amoozadeh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ligustilide inhibits tumour necrosis factor-alpha-induced autophagy during C2C12 cells differentiation

(2015) Ying Shi et al.   BIOMEDICINE & PHARMACOTHERAPY

Tumor necrosis factor alpha stimulates p62 accumulation and enhances proteasome activity independently of ROS

(2015) Caleigh M. Opperman et al.   CELL BIOLOGY AND TOXICOLOGY

TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells

(2015) Mei-Xia Wang et al.   EXPERIMENTAL NEUROLOGY

Protective effect of hydrogen sulfide on TNF-α and IFN-γ-induced injury of intestinal epithelial barrier function in Caco-2 monolayers

(2015) Shan-wen Chen et al.   INFLAMMATION RESEARCH

Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation

(2015) Prashant K. Nighot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells

(2015) Jichen Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inhibition of autophagy by bafilomycin A1 promotes chemosensitivity of gastric cancer cells

(2015) Liang-qing Li et al.   TUMOR BIOLOGY

PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway

(2014) Xiaofang Xing et al.   ANTI-CANCER DRUGS

The use of sirolimus (rapamycin) in the management of refractory inflammatory bowel disease in children

(2014) Mohamed Mutalib et al.   Journal of Crohns & Colitis

Tetrandrine blocks autophagic flux and induces apoptosis via energetic impairment in cancer cells

(2014) W Qiu et al.   Cell Death & Disease

Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice

(2014) Arnaud Francois et al.   Molecular Brain

Bifidobacteria Stabilize Claudins at Tight Junctions and Prevent Intestinal Barrier Dysfunction in Mouse Necrotizing Enterocolitis

(2013) Kelly R. Bergmann et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Modulation of Intestinal Folate Absorption by Erythropoietin in Vitro

(2013) Junkai Yan et al.   MOLECULAR PHARMACEUTICS

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

(2013) Carmine Settembre et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells

(2012) Ji Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Targeting of mTORC1/2 by the mTOR kinase inhibitor PP242 induces apoptosis in AML cells under conditions mimicking the bone marrow microenvironment

(2012) Z. Zeng et al.   BLOOD

Intestinal Epithelial Cells with Impaired Autophagy Lose Their Adhesive Capacity in the Presence of TNF-α

(2012) Masaya Saito et al.   DIGESTIVE DISEASES AND SCIENCES

Loss of Claudins 2 and 15 From Mice Causes Defects in Paracellular Na+ Flow and Nutrient Transport in Gut and Leads to Death from Malnutrition

(2012) Masami Wada et al.   GASTROENTEROLOGY

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

(2011) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation

(2011) P Dhawan et al.   ONCOGENE

Infliximab for Crohnʼs disease in the Swiss IBD Cohort Study

(2010) Pascal Juillerat et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

TNFα-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFκB signaling

(2010) Maren Amasheh et al.   JOURNAL OF CELL SCIENCE

The protective effect of enteric glial cells on intestinal epithelial barrier function is enhanced by inhibiting inducible nitric oxide synthase activity under lipopolysaccharide stimulation

(2010) Wei-Dong Xiao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Claudin-2-dependent Changes in Noncharged Solute Flux Are Mediated by the Extracellular Domains and Require Attachment to the PDZ-scaffold

(2009) Christina M. Van Itallie et al.   Annals of the New York Academy of Sciences

ATG16L1 T300A Shows Strong Associations With Disease Subgroups in a Large Australian IBD Population: Further Support for Significant Disease Heterogeneity

(2008) Elizabeth V. Fowler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The density of small tight junction pores varies among cell types and is increased by expression of claudin-2

(2008) C. M. Van Itallie et al.   JOURNAL OF CELL SCIENCE

Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation

(2008) Christopher R Weber et al.   LABORATORY INVESTIGATION