The T300A Crohn’s disease risk polymorphism impairs function of the WD40 domain of ATG16L1

Autophagy Mediates Tolerance to Staphylococcus aureus Alpha-Toxin

(2015) Katie Maurer et al.   Cell Host & Microbe

The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon

(2015) Wesley A Grimm et al.   GUT

ATG16L1 T300A Polymorphism is Correlated with Gastric Cancer Susceptibility

(2015) Florin Burada et al.   PATHOLOGY & ONCOLOGY RESEARCH

Polymorphisms in Autophagy Genes Are Associated with Paget Disease of Bone

(2015) Ricardo Usategui-Martín et al.   PLoS One

Selective autophagy against membranous compartments

(2014) Felipe X Pimentel-Muiños et al.   Autophagy

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

(2014) Jayoung Choi et al.   IMMUNITY

Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

(2014) Vanessa M. Hubbard-Lucey et al.   IMMUNITY

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Autophagy in Antimicrobial Immunity

(2014) Ligia C. Gomes et al.   MOLECULAR CELL

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins

(2014) Daniel J Klionsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

TMEM59 defines a novel ATG16L1-binding motif that promotes local activation of LC3

(2013) Emilio Boada-Romero et al.   EMBO JOURNAL

FIP200 regulates targeting of Atg16L1 to the isolation membrane

(2013) Taki Nishimura et al.   EMBO REPORTS

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection

(2013) Kara L. Conway et al.   GASTROENTEROLOGY

The Protein ATG16L1 Suppresses Inflammatory Cytokines Induced by the Intracellular Sensors Nod1 and Nod2 in an Autophagy-Independent Manner

(2013) Matthew T. Sorbara et al.   IMMUNITY

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

(2013) Naonobu Fujita et al.   JOURNAL OF CELL BIOLOGY

Autophagy and Crohn's Disease

(2013) Hang Thi Thu Nguyen et al.   Journal of Innate Immunity

The Crohn's disease: associated ATG16L1 variant andSalmonellainvasion

(2013) Jeannette S Messer et al.   BMJ Open

Modulation of inflammation by autophagy: consequences for Crohn's disease

(2012) Theo S Plantinga et al.   CURRENT OPINION IN PHARMACOLOGY

Etiology of Crohn’s disease: many roads lead to autophagy

(2012) Pierre Lapaquette et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy

(2012) Noor Gammoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crohn disease: A current perspective on genetics, autophagy and immunity

(2011) Thaddeus S. Stappenbeck et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2

(2011) T. S. Plantinga et al.   GUT

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

ATG16L1 and NOD2 Interact in an Autophagy-Dependent Antibacterial Pathway Implicated in Crohn's Disease Pathogenesis

(2010) Craig R. Homer et al.   GASTROENTEROLOGY

The Novel Membrane Protein TMEM59 Modulates Complex Glycosylation, Cell Surface Expression, and Secretion of the Amyloid Precursor Protein

(2010) Sylvia Ullrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WD40 Repeat Propellers Define a Ubiquitin-Binding Domain that Regulates Turnover of F Box Proteins

(2010) Natasha Pashkova et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy and innate immunity: Triggering, targeting and tuning

(2010) Rhea Sumpter et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

Autophagy, Immunity, and Microbial Adaptations

(2009) Vojo Deretic et al.   Cell Host & Microbe

Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak

(2009) Martina Klee et al.   EMBO JOURNAL

Molecular basis of canonical and bactericidal autophagy

(2009) T. Noda et al.   INTERNATIONAL IMMUNOLOGY

Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy

(2009) Naonobu Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation

(2008) Takashi Itoh et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Impaired Autophagy of an Intracellular Pathogen Induced by a Crohn's Disease Associated ATG16L1 Variant

(2008) Petric Kuballa et al.   PLoS One

Role of the JNK signal transduction pathway in inflammatory bowel disease

(2008) Praveen K Roy et al.   WORLD JOURNAL OF GASTROENTEROLOGY