ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS–STING

Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases

(2018) Eric G. Stefanich et al.   BIOCHEMICAL PHARMACOLOGY

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

(2018) Thaneas Prabakaran et al.   EMBO JOURNAL

Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases

(2017) Susanna Nikolaus et al.   GASTROENTEROLOGY

Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease

(2017) Mircea T. Chiriac et al.   GASTROENTEROLOGY

Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy

(2017) Kareen Bartsch et al.   HUMAN MOLECULAR GENETICS

P418 Pharmacodynamic biomarkers demonstrate dose-dependent pharmacological activity of the IL-22Fc fusion protein UTR1147A in healthy volunteers in a phase 1a clinical trial

(2017) A. Lekkerkerker et al.   Journal of Crohns & Colitis

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

(2017) Markus Tschurtschenthaler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

(2017) Silvia Cerboni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium

(2017) Yu Matsuzawa-Ishimoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

(2017) Bridget Larkin et al.   JOURNAL OF IMMUNOLOGY

Induction therapy with the selective interleukin-23 inhibitor risankizumab in patients with moderate-to-severe Crohn's disease: a randomised, double-blind, placebo-controlled phase 2 study

(2017) Brian G Feagan et al.   LANCET

Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer

(2017) C Wang et al.   Mucosal Immunology

The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis

(2016) Claudia Günther et al.   JOURNAL OF CLINICAL INVESTIGATION

A pathogenic role for T cell–derived IL-22BP in inflammatory bowel disease

(2016) Penelope Pelczar et al.   SCIENCE

CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

(2016) Diana Legarda et al.   Cell Reports

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

(2016) Konrad Aden et al.   Cell Reports

Autophagy positively regulates DNA damage recognition by nucleotide excision repair

(2015) Lei Qiang et al.   Autophagy

Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins

(2015) Lina Mouna et al.   Autophagy

STAT3 Inhibition Enhances the Therapeutic Efficacy of Immunogenic Chemotherapy by Stimulating Type 1 Interferon Production by Cancer Cells

(2015) Heng Yang et al.   CANCER RESEARCH

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

(2015) Caroline A. Lindemans et al.   NATURE

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Loss of autophagy causes a synthetic lethal deficiency in DNA repair

(2015) Emma Y. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

(2014) Tu Anh N. Pham et al.   Cell Host & Microbe

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

(2014) Marius Dannappel et al.   NATURE

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

(2014) Sumaira Z Hasnain et al.   NATURE MEDICINE

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

(2014) K. G. Lassen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The type I IFN signature as a biomarker of preclinical rheumatoid arthritis

(2013) Joyce Lübbers et al.   ANNALS OF THE RHEUMATIC DISEASES

Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis

(2013) Alexandre Sze et al.   Cell Host & Microbe

Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease

(2013) J Jasper Deuring et al.   GUT

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation

(2013) Lisa A. Mielke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ER stress transcription factor Xbp1 suppresses intestinal tumorigenesis and directs intestinal stem cells

(2013) Lukas Niederreiter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

Therapeutic opportunities of the IL-22–IL-22R1 system

(2013) Robert Sabat et al.   NATURE REVIEWS DRUG DISCOVERY

IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis

(2013) C. L. Zindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

IL-10 Promotes Production of Intestinal Mucus by Suppressing Protein Misfolding and Endoplasmic Reticulum Stress in Goblet Cells

(2012) Sumaira Z. Hasnain et al.   GASTROENTEROLOGY

Phenotype–Genotype Profiles in Crohnʼs Disease Predicted by Genetic Markers in Autophagy-Related Genes (GOIA Study II)

(2012) Cecília Durães et al.   INFLAMMATORY BOWEL DISEASES

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

(2012) Samuel Huber et al.   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation

(2012) Karin Breuer et al.   NUCLEIC ACIDS RESEARCH

Primer3—new capabilities and interfaces

(2012) Andreas Untergasser et al.   NUCLEIC ACIDS RESEARCH

VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R

(2011) Hanbo Chen et al.   BMC BIOINFORMATICS

RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

(2011) Linde Duprez et al.   IMMUNITY

IL-23–responsive innate lymphoid cells are increased in inflammatory bowel disease

(2011) Alessandra Geremia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

(2011) Patrick-Simon Welz et al.   NATURE

Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis

(2011) Claudia Günther et al.   NATURE

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine

(2010) Ken Cadwell et al.   CELL

TheN-Ethyl-N-Nitrosourea-InducedGoldenticketMouse Mutant Reveals an Essential Function ofStingin theIn VivoInterferon Response toListeria monocytogenesand Cyclic Dinucleotides

(2010) John-Demian Sauer et al.   INFECTION AND IMMUNITY

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Early Production of IL-22 but Not IL-17 by Peripheral Blood Mononuclear Cells Exposed to live Borrelia burgdorferi: The Role of Monocytes and Interleukin-1

(2010) Malte Bachmann et al.   PLoS Pathogens

STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing

(2009) Geethanjali Pickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE