TREM-1 Inhibition Restores Impaired Autophagy Activity and Reduces Colitis in Mice

Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

(2017) Markus Tschurtschenthaler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crohn's disease

(2017) Joana Torres et al.   LANCET

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives

(2017) Alessandra Tammaro et al.   PHARMACOLOGY & THERAPEUTICS

Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation

(2016) A. Tammaro et al.   Scientific Reports

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide

(2015) Christophe Macri et al.   Autophagy

Role of endoplasmic reticulum stress and autophagy as interlinking pathways in the pathogenesis of inflammatory bowel disease

(2015) Shuhei Hosomi et al.   CURRENT OPINION IN GASTROENTEROLOGY

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic Reticulum Stress in Intestinal Epithelial Cell Function and Inflammatory Bowel Disease

(2015) Katherine Luo et al.   Gastroenterology Research and Practice

Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1α (IRE1α) in human colon cancer cells

(2014) Yosuke Shimodaira et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A LC3-Interacting Motif in the Influenza A Virus M2 Protein Is Required to Subvert Autophagy and Maintain Virion Stability

(2014) Rupert Beale et al.   Cell Host & Microbe

The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis

(2014) Marco Genua et al.   Journal of Translational Medicine

The gut microbiota and inflammatory bowel disease

(2014) Katsuyoshi Matsuoka et al.   Seminars in Immunopathology

Manipulation of autophagy by HCMV infection is involved in mTOR and influences the replication of virus

(2013) J. Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Intestinal Epithelial Autophagy Is Essential for Host Defense against Invasive Bacteria

(2013) Jamaal L. Benjamin et al.   Cell Host & Microbe

Inflammatory Bowel Disease: Dysfunction of Autophagy?

(2013) Michael Scharl et al.   DIGESTIVE DISEASES

TREM-1 inhibition attenuates inflammation and tumor within the colon

(2013) Jiangang Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Distinct Signaling Cascades of TREM-1, TLR and NLR in Neutrophils and Monocytic Cells

(2013) Steve Prüfer et al.   Journal of Innate Immunity

Introduction: the unfolded protein response’s role in disease pathophysiology

(2013) Arthur Kaser et al.   Seminars in Immunopathology

Effects of a TREM-Like Transcript 1–Derived Peptide During Hypodynamic Septic Shock in Pigs

(2013) Marc Derive et al.   SHOCK

Commensal-Innate Immune Miscommunication in IBD Pathogenesis

(2012) Elke Cario   DIGESTIVE DISEASES

Evaluation of general 16S ribosomal RNA gene PCR primers for classical and next-generation sequencing-based diversity studies

(2012) Anna Klindworth et al.   NUCLEIC ACIDS RESEARCH

Immune aspects of the pathogenesis of inflammatory bowel disease

(2012) Tadakazu Hisamatsu et al.   PHARMACOLOGY & THERAPEUTICS

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

UCHIME improves sensitivity and speed of chimera detection

(2011) Robert C. Edgar et al.   BIOINFORMATICS

Altered Endoplasmic Reticulum Stress Affects Translation in Inactive Colon Tissue From Patients With Ulcerative Colitis

(2011) Xavier Tréton et al.   GASTROENTEROLOGY

Developing an instrument to assess the endoscopic severity of ulcerative colitis: the Ulcerative Colitis Endoscopic Index of Severity (UCEIS)

(2011) Simon P L Travis et al.   GUT

Crohn's disease: NOD2, autophagy and ER stress converge

(2011) T. Fritz et al.   GUT

Search and clustering orders of magnitude faster than BLAST

(2010) Robert C. Edgar   BIOINFORMATICS

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis

(2010) Arthur Kaser et al.   CURRENT OPINION IN GASTROENTEROLOGY

A Pyrosequencing Study in Twins Shows That Gastrointestinal Microbial Profiles Vary With Inflammatory Bowel Disease Phenotypes

(2010) Ben P. Willing et al.   GASTROENTEROLOGY

Genetic variation in the autophagy gene ULK1 and risk of Crohnʼs disease

(2010) Liesbet Henckaerts et al.   INFLAMMATORY BOWEL DISEASES

Regulation of innate immune responses by autophagy-related proteins

(2010) Tatsuya Saitoh et al.   JOURNAL OF CELL BIOLOGY

An essential role for XBP-1 in host protection against immune activation in C. elegans

(2010) Claire E. Richardson et al.   NATURE

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

TREM and TREM-like receptors in inflammation and disease

(2009) Jill W Ford et al.   CURRENT OPINION IN IMMUNOLOGY

Low counts of Faecalibacterium prausnitzii in colitis microbiota

(2009) H. Sokol et al.   INFLAMMATORY BOWEL DISEASES

Endoplasmic reticulum stress in the intestinal epithelium and inflammatory bowel disease

(2009) Arthur Kaser et al.   SEMINARS IN IMMUNOLOGY

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

Toll-like receptors control autophagy

(2008) Mónica A Delgado et al.   EMBO JOURNAL

Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort

(2008) R L Roberts et al.   GENES AND IMMUNITY

Autophagy and pattern recognition receptors in innate immunity

(2008) Monica Delgado et al.   IMMUNOLOGICAL REVIEWS

The TREM-1/DAP12 pathway

(2008) Anja S. Tessarz et al.   IMMUNOLOGY LETTERS

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL