Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy
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Title
Targeting amyloid clearance in Alzheimer's disease as a therapeutic strategy
Authors
Keywords
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Journal
BRITISH JOURNAL OF PHARMACOLOGY
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2019-02-02
DOI
10.1111/bph.14593
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Note: Only part of the references are listed.- Alzheimer’s Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence
- (2018) Maya L. Gosztyla et al. JOURNAL OF ALZHEIMERS DISEASE
- The Effect of Chronic Cerebral Hypoperfusion on Amyloid-β Metabolism in a Transgenic Mouse Model of Alzheimer’s Disease (PS1V97L)
- (2018) Heyun Yang et al. JOURNAL OF ALZHEIMERS DISEASE
- Cerebrospinal Fluid Levels of Angiotensin-Converting Enzyme Are Associated with Amyloid-β42 Burden in Alzheimer’s Disease
- (2018) Natalia P. Rocha et al. JOURNAL OF ALZHEIMERS DISEASE
- Targeting Alzheimer's disease with gene and cell therapies
- (2018) R. Loera-Valencia et al. JOURNAL OF INTERNAL MEDICINE
- Complex neuroprotective and neurotoxic effects of histone deacetylases
- (2018) Elizabeth A. Thomas et al. JOURNAL OF NEUROCHEMISTRY
- Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway
- (2018) Ahmed S. Kamel et al. MOLECULAR NEUROBIOLOGY
- TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function
- (2018) Yingjun Zhao et al. NEURON
- Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
- (2018) David Adams et al. NEW ENGLAND JOURNAL OF MEDICINE
- β-Amyloid accumulation in the human brain after one night of sleep deprivation
- (2018) Ehsan Shokri-Kojori et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insulin-Degrading Enzyme in the Fight against Alzheimer’s Disease
- (2018) Igor V. Kurochkin et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Insulin-degrading enzyme is not secreted from cultured cells
- (2018) Eun Suk Song et al. Scientific Reports
- γ-Secretase-Mediated Regulation of Neprilysin: Influence of Cell Density and Aging and Modulation by Imatinib
- (2018) Charlotte Bauer et al. JOURNAL OF ALZHEIMERS DISEASE
- Altered NEP2 Expression and Activity in Mild Cognitive Impairment and Alzheimer's Disease
- (2018) Jeffrey Y. Huang et al. JOURNAL OF ALZHEIMERS DISEASE
- Plasma Transthyretin as a Candidate Marker for Alzheimer's Disease
- (2018) Latha Velayudhan et al. JOURNAL OF ALZHEIMERS DISEASE
- Sleep in Frontotemporal Dementia is Equally or Possibly More Disrupted, and at an Earlier Stage, When Compared to Sleep in Alzheimer's Disease
- (2018) Anastasios Bonakis et al. JOURNAL OF ALZHEIMERS DISEASE
- Transthyretin Stabilization by Iododiflunisal Promotes Amyloid-β Peptide Clearance, Decreases its Deposition, and Ameliorates Cognitive Deficits in an Alzheimer's Disease Mouse Model
- (2018) Carlos A. Ribeiro et al. JOURNAL OF ALZHEIMERS DISEASE
- Association between Stroke and Alzheimer's Disease: Systematic Review and Meta-Analysis
- (2018) Jing Zhou et al. JOURNAL OF ALZHEIMERS DISEASE
- Postsynaptic Proteome of Non-Demented Individuals with Alzheimer’s Disease Neuropathology
- (2018) Olga Zolochevska et al. JOURNAL OF ALZHEIMERS DISEASE
- Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
- (2018) Barry Boland et al. NATURE REVIEWS DRUG DISCOVERY
- Neprilysin inhibition promotes corneal wound healing
- (2018) Rachel M. Genova et al. Scientific Reports
- Self‐Reported Sleep Duration and Quality and Cardiovascular Disease and Mortality: A Dose‐Response Meta‐Analysis
- (2018) Chun Shing Kwok et al. Journal of the American Heart Association
- 5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease
- (2018) Christian Klein et al. Acta Neuropathologica Communications
- Sleep Deprivation Induced Plasma Amyloid-β Transport Disturbance in Healthy Young Adults
- (2017) Meng Wei et al. JOURNAL OF ALZHEIMERS DISEASE
- PSD-93 Attenuates Amyloid-β-Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-β
- (2017) Linjie Yu et al. JOURNAL OF ALZHEIMERS DISEASE
- Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP
- (2017) Saket M. Nigam et al. JOURNAL OF NEUROCHEMISTRY
- Dementia risk and prevention by targeting modifiable vascular risk factors
- (2017) Sana Tariq et al. JOURNAL OF NEUROCHEMISTRY
- Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition
- (2017) Chia-Chen Liu et al. JOURNAL OF NEUROSCIENCE
- Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease
- (2017) Hari Shanker Sharma et al. MOLECULAR NEUROBIOLOGY
- Idiopathic REM sleep behaviour disorder and neurodegeneration — an update
- (2017) Birgit Högl et al. Nature Reviews Neurology
- A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain
- (2017) Jun Wang et al. Nature Reviews Neurology
- Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways
- (2017) Naoki Yamamoto et al. NEUROSCIENCE
- Meta-analysis of expression and function of neprilysin in Alzheimer’s disease
- (2017) Huifeng Zhang et al. NEUROSCIENCE LETTERS
- The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
- (2017) Simon D Harding et al. NUCLEIC ACIDS RESEARCH
- Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease
- (2017) Ayelén Bulloj et al. JOURNAL OF ALZHEIMERS DISEASE
- Green tea reduces body fat via upregulation of neprilysin
- (2016) M Muenzner et al. INTERNATIONAL JOURNAL OF OBESITY
- Transthyretin Suppresses Amyloid-β Secretion by Interfering with Processing of the Amyloid-β Protein Precursor
- (2016) Xinyi Li et al. JOURNAL OF ALZHEIMERS DISEASE
- The association of renin-angiotensin system blockade use with the risks of cognitive impairment of aging and Alzheimer’s disease: A meta-analysis
- (2016) Shan Zhuang et al. JOURNAL OF CLINICAL NEUROSCIENCE
- The amyloid cascade hypothesis: are we poised for success or failure?
- (2016) Eric Karran et al. JOURNAL OF NEUROCHEMISTRY
- Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid- Alterations in a Monkey Model of Type 1 Diabetes
- (2016) J. Morales-Corraliza et al. JOURNAL OF NEUROSCIENCE
- Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice
- (2016) Melanie Hüttenrauch et al. MOLECULAR NEUROBIOLOGY
- Long-term neprilysin inhibition — implications for ARNIs
- (2016) Duncan J. Campbell Nature Reviews Cardiology
- Major amyloid-β–degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex
- (2016) Javier Pacheco-Quinto et al. NEUROBIOLOGY OF AGING
- Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology
- (2016) David J. Koss et al. NEUROBIOLOGY OF DISEASE
- N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin
- (2016) A. Ian Smith et al. Scientific Reports
- Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology
- (2016) Patrick Gavin Kehoe et al. Alzheimers Research & Therapy
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- (2016) Miriam Ries et al. Frontiers in Aging Neuroscience
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- (2016) David Briley et al. Scientific Reports
- Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues
- (2015) Ekaterina G. Kochkina et al. BIOGERONTOLOGY
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- (2015) Zhiyou Cai et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease
- (2015) Robert Baranello et al. Current Alzheimer Research
- Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability
- (2015) Masashi Tabuchi et al. CURRENT BIOLOGY
- (−)-Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer׳s disease model mice by upregulating neprilysin expression
- (2015) Xiang Chang et al. EXPERIMENTAL CELL RESEARCH
- Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin
- (2015) Rajni Parthasarathy et al. EXPERIMENTAL EYE RESEARCH
- Role of caspase-3 in regulation of the amyloid-degrading neuropeptidase neprilysin level in the rat cortex after hypoxia
- (2015) D. I. Kozlova et al. JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
- New Insights into Epigenetic and Pharmacological Regulation of Amyloid-Degrading Enzymes
- (2015) Natalia N. Nalivaeva et al. NEUROCHEMICAL RESEARCH
- The activity of blood serum cholinesterases and neprilysin as potential biomarkers of mild-cognitive impairment and Alzheimer’s disease
- (2015) I. А. Zhuravin et al. Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova
- Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism
- (2015) Caroline Kerridge et al. Frontiers in Neuroscience
- Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes
- (2014) Naoki Yamamoto et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain
- (2014) Caroline Kerridge et al. JOURNAL OF NEUROCHEMISTRY
- Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme
- (2014) Shuyu Liu et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure
- (2014) John J.V. McMurray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models
- (2014) Mathew Blurton-Jones et al. Stem Cell Research & Therapy
- Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
- (2014) Robert A. Marr et al. Frontiers in Aging Neuroscience
- Nonsteroidal Selective Androgen Receptor Modulators and Selective Estrogen Receptor β Agonists Moderate Cognitive Deficits and Amyloid-β Levels in a Mouse Model of Alzheimer’s Disease
- (2013) Sonia George et al. ACS Chemical Neuroscience
- Sustained peripheral depletion of amyloid-β with a novel form of neprilysin does not affect central levels of amyloid-β
- (2013) Simon J. Henderson et al. BRAIN
- Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism
- (2013) Karin E. Sandoval et al. BRAIN RESEARCH
- Valproic Acid Reduces Neuritic Plaque Formation and Improves Learning Deficits in APPSwe/PS1A246ETransgenic Mice via Preventing the Prenatal Hypoxia-Induced Down-Regulation of Neprilysin
- (2013) Zheng Wang et al. CNS Neuroscience & Therapeutics
- Transcriptional Regulation of Insulin-degrading Enzyme Modulates Mitochondrial Amyloid β (Aβ) Peptide Catabolism and Functionality
- (2013) María C. Leal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes
- (2013) Javier Pacheco-Quinto et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction
- (2013) Christian Klein et al. NEUROPHARMACOLOGY
- Intracranial Injection of AAV Expressing NEP but Not IDE Reduces Amyloid Pathology in APP+PS1 Transgenic Mice
- (2013) Nikisha Carty et al. PLoS One
- Proteolytically Inactive Insulin-Degrading Enzyme Inhibits Amyloid Formation Yielding Non-Neurotoxic Aβ Peptide Aggregates
- (2013) Matias B. de Tullio et al. PLoS One
- Sleep Drives Metabolite Clearance from the Adult Brain
- (2013) L. Xie et al. SCIENCE
- Sleep Fragmentation and the Risk of Incident Alzheimer's Disease and Cognitive Decline in Older Persons
- (2013) Andrew S. P. Lim et al. SLEEP
- Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes
- (2013) Takeshi Katsuda et al. Scientific Reports
- Sleep Quality and Preclinical Alzheimer Disease
- (2013) Yo-El S. Ju et al. JAMA Neurology
- Transthyretin is a metallopeptidase with an inducible active site
- (2012) Márcia A. Liz et al. BIOCHEMICAL JOURNAL
- Neurotoxicity and Memory Deficits Induced by Soluble Low-Molecular-Weight Amyloid- 1-42 Oligomers Are Revealed In Vivo by Using a Novel Animal Model
- (2012) J. Brouillette et al. JOURNAL OF NEUROSCIENCE
- A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
- (2012) Thorlakur Jonsson et al. NATURE
- Supercentenarians and transthyretin amyloidosis: The next frontier of human life extension
- (2012) L. Stephen Coles et al. PREVENTIVE MEDICINE
- ApoE-Directed Therapeutics Rapidly Clear -Amyloid and Reverse Deficits in AD Mouse Models
- (2012) P. E. Cramer et al. SCIENCE
- A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid
- (2012) J. J. Iliff et al. Science Translational Medicine
- The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: Characterizing a new regulatory motif
- (2011) Bryan Maloney et al. GENE
- Effect of Sodium Valproate Administration on Brain Neprilysin Expression and Memory in Rats
- (2011) Natalia N. Nalivaeva et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?
- (2011) Natalia N. Nalivaeva et al. JOURNAL OF NEUROCHEMISTRY
- Atrial Fibrillation and Risk of Dementia: A Prospective Cohort Study
- (2011) Sascha Dublin et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Preventive and therapeutic types of environmental enrichment counteract beta amyloid pathology by different molecular mechanisms
- (2011) Arne Herring et al. NEUROBIOLOGY OF DISEASE
- Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-ß Peptide
- (2011) Konstantin Glebov et al. Neurodegenerative Diseases
- Amyloid-β Peptide Is a Substrate of the Human 20S Proteasome
- (2010) Xiaobei Zhao et al. ACS Chemical Neuroscience
- Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory
- (2010) Daniela Puzzo et al. ANNALS OF NEUROLOGY
- Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice
- (2010) Yuan-Shih Hu et al. FASEB JOURNAL
- Neprilysin, obesity and the metabolic syndrome
- (2010) K F Standeven et al. INTERNATIONAL JOURNAL OF OBESITY
- The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway
- (2010) Nikolai D. Belyaev et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Circulating neprilysin clears brain amyloid
- (2010) Yinxing Liu et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Decreased Clearance of CNS -Amyloid in Alzheimer's Disease
- (2010) K. G. Mawuenyega et al. SCIENCE
- A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimers Disease
- (2009) Sergey Kalinin et al. Current Alzheimer Research
- Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element
- (2009) Zhi-Min Xiao et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Aminopeptidase A contributes to the N-terminal truncation of amyloid β-peptide
- (2009) Jean Sevalle et al. JOURNAL OF NEUROCHEMISTRY
- The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal
- (2009) John Hardy JOURNAL OF NEUROCHEMISTRY
- Increased Accumulation of Intraneuronal Amyloid β in HIV-Infected Patients
- (2009) Cristian L. Achim et al. Journal of Neuroimmune Pharmacology
- Environmental Experience Modulates Ischemia-Induced Amyloidogenesis and Enhances Functional Recovery
- (2009) Teresita L. Briones et al. JOURNAL OF NEUROTRAUMA
- Insulin-degrading enzyme is exported via an unconventional protein secretion pathway
- (2009) Ji Zhao et al. Molecular Neurodegeneration
- Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease
- (2009) Yinxing Liu et al. MOLECULAR THERAPY
- Amyloid- Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
- (2009) J.-E. Kang et al. SCIENCE
- Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease
- (2008) Nikolai D Belyaev et al. EMBO REPORTS
- Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences
- (2008) Alison R. Whyteside et al. FEBS LETTERS
- apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
- (2008) Rashid Deane et al. JOURNAL OF CLINICAL INVESTIGATION
- Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models
- (2008) Hong Qing et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity
- (2008) Chiara Ciaccio et al. JOURNAL OF MOLECULAR BIOLOGY
- Angiotensin-converting enzyme 2 in the brain: properties and future directions
- (2008) Huijing Xia et al. JOURNAL OF NEUROCHEMISTRY
- Peripherally expressed neprilysin reduces brain amyloid burden: A novel approach for treating Alzheimer's disease
- (2008) Hanjun Guan et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Minocycline prevents Aβ(25–35)-induced reduction of somatostatin and neprilysin content in rat temporal cortex
- (2008) E. Burgos-Ramos et al. LIFE SCIENCES
- Adeno-associated Viral (AAV) Serotype 5 Vector Mediated Gene Delivery of Endothelin-converting Enzyme Reduces Aβ Deposits in APP + PS1 Transgenic Mice
- (2008) Niki C Carty et al. MOLECULAR THERAPY
- Cerebral Cortical Arteriolar Angiopathy, Vascular Beta-Amyloid, Smooth Muscle Actin, Braak Stage, and APOE Genotype
- (2008) Edward G. Stopa et al. STROKE
- Transthyretin: A key gene involved in the maintenance of memory capacities during aging
- (2007) Jonathan Brouillette et al. NEUROBIOLOGY OF AGING
- Aβ inhibits the proteasome and enhances amyloid and tau accumulation
- (2007) Bertrand P. Tseng et al. NEUROBIOLOGY OF AGING
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