Stimulation of ACE2/ANG(1–7)/Mas Axis by Diminazene Ameliorates Alzheimer’s Disease in the D-Galactose-Ovariectomized Rat Model: Role of PI3K/Akt Pathway

Angiotensin II Receptor Blockers Attenuate Lipopolysaccharide-Induced Memory Impairment by Modulation of NF-κB-Mediated BDNF/CREB Expression and Apoptosis in Spontaneously Hypertensive Rats

(2017) Ruby Goel et al.   MOLECULAR NEUROBIOLOGY

Melatonin Alleviates the Epilepsy-Associated Impairments in Hippocampal LTP and Spatial Learning Through Rescue of Surface GluR2 Expression at Hippocampal CA1 Synapses

(2017) Yue Ma et al.   NEUROCHEMICAL RESEARCH

Diminazene aceturate, an angiotensin-converting enzyme II activator, prevents gastric mucosal damage in mice: Role of the angiotensin-(1–7)/Mas receptor axis

(2016) Luan Kelves M. Souza et al.   BIOCHEMICAL PHARMACOLOGY

Renin-Angiotensin-Aldosterone System: A Current Drug Target for the Management of Neuropathic Pain

(2016) Arunachalam Muthuraman et al.   CURRENT DRUG TARGETS

Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium

(2016) Lifei Tao et al.   Journal of Neuroinflammation

Combined exercise ameliorates ovariectomy-induced cognitive impairment by enhancing cell proliferation and suppressing apoptosis

(2016) Tae-Woon Kim et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

(2016) Shafiq Ur Rehman et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective Effect of Nanodiamond in Alzheimer’s Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling

(2016) Shawqi H. Alawdi et al.   MOLECULAR NEUROBIOLOGY

Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors

(2016) Lei Wang et al.   NEUROPHARMACOLOGY

Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways

(2016) Daiying Zuo et al.   NEUROTOXICITY RESEARCH

Inflammation and increased IDO in hippocampus contribute to depression-like behavior induced by estrogen deficiency

(2015) Yongjun Xu et al.   BEHAVIOURAL BRAIN RESEARCH

Down-sizing of neuronal network activity and density of presynaptic terminals by pathological acidosis are efficiently prevented by Diminazene Aceturate

(2015) Roberta de Ceglia et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroprotective Mechanisms of the ACE2–Angiotensin-(1-7)–Mas Axis in Stroke

(2015) Douglas M. Bennion et al.   CURRENT HYPERTENSION REPORTS

Pharmacological significance of the interplay between angiotensin receptors: MAS receptors as putative final mediators of the effects elicited by angiotensin AT1 receptors antagonists

(2015) Larissa Pernomian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic StrokeNovelty and Significance

(2015) Douglas M. Bennion et al.   HYPERTENSION

Astrocytes Protect Neurons from Aβ1-42 Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1

(2015) Diana Aguirre-Rueda et al.   International Journal of Medical Sciences

Cognition Enhancing and Neuromodulatory Propensity of Bacopa monniera Extract Against Scopolamine Induced Cognitive Impairments in Rat Hippocampus

(2015) M. D. Pandareesh et al.   NEUROCHEMICAL RESEARCH

Simvastatin prevents β-amyloid25–35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate

(2015) Conghui Wang et al.   NEUROPHARMACOLOGY

Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats

(2015) H.F. Zhao et al.   NEUROSCIENCE

Angiotensin-(1–7) counteracts the effects of Ang II on vascular smooth muscle cells, vascular remodeling and hemorrhagic stroke: Role of the NFкB inflammatory pathway

(2015) Ji C. Bihl et al.   VASCULAR PHARMACOLOGY

O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling

(2015) Jianhua Shi et al.   Scientific Reports

Neuroprotective Effects of Angiotensin Receptor Blockers

(2014) Sonia Villapol et al.   AMERICAN JOURNAL OF HYPERTENSION

Angiotensin-(1-7) improves cognitive function in rats with chronic cerebral hypoperfusion

(2014) Wei Xie et al.   BRAIN RESEARCH

Hydroxy-safflor yellow A attenuates Aβ1-42-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway

(2014) Zuo-hui Zhang et al.   BRAIN RESEARCH

Protective axis of the renin–angiotensin system in the brain

(2014) Mariela M. Gironacci et al.   CLINICAL SCIENCE

Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme

(2014) Shuyu Liu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of the angiotensin-(1-7)/Mas/PI3K/Akt/nitric oxide axis and the possible role of atrial natriuretic peptide in an acute atrial tachycardia canine model

(2014) Jun Zhao et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

(2014) Gabriel Olmos et al.   MEDIATORS OF INFLAMMATION

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

(2014) Brice Ongali et al.   NEUROBIOLOGY OF DISEASE

Activation of the ACE2/Ang-(1–7)/Mas pathway reduces oxygen–glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction

(2014) J. Zheng et al.   NEUROSCIENCE

Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms

(2014) Yoelvis García-Mesa et al.   PSYCHONEUROENDOCRINOLOGY

Dietary regulation of PI3K/AKT/GSK-3β pathway in Alzheimer’s disease

(2014) Yasuko Kitagishi et al.   Alzheimers Research & Therapy

Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes

(2014) J. Scott Miners et al.   Frontiers in Aging Neuroscience

Regulation of STAT3 by miR-106a is linked to cognitive impairment in ovariectomized mice

(2013) Min Zhang et al.   BRAIN RESEARCH

Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

(2013) Emma Louise Ashby et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke

(2013) Robert W. Regenhardt et al.   NEUROPHARMACOLOGY

Inactivation of JAK2/STAT3 Signaling Axis and Downregulation of M1 mAChR Cause Cognitive Impairment in klotho Mutant Mice, a Genetic Model of Aging

(2013) Seok-Joo Park et al.   NEUROPSYCHOPHARMACOLOGY

Suppressing inflammation by inhibiting the NF-κB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia

(2012) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Immunohistochemical localization of the angiotensin-(1–7) receptor Mas in the murine forebrain

(2012) M. Freund et al.   CELL AND TISSUE RESEARCH

Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains

(2012) Minjie Tian et al.   FEBS LETTERS

Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy

(2012) Zhen Liu et al.   LABORATORY INVESTIGATION

The levels of renin–angiotensin related components are modified in the hippocampus of rats submitted to pilocarpine model of epilepsy

(2012) Telma Luciana Furtado Gouveia et al.   NEUROCHEMISTRY INTERNATIONAL

Angiotensin II-Induced Mitochondrial Nox4 Is a Major Endogenous Source of Oxidative Stress in Kidney Tubular Cells

(2012) Su-Mi Kim et al.   PLoS One

A Review: Inflammatory Process in Alzheimer's Disease, Role of Cytokines

(2012) Jose Miguel Rubio-Perez et al.   TheScientificWorldJOURNAL

Caspase-3 activation as a bifurcation point between plasticity and cell death

(2012) Shikha Snigdha et al.   Neuroscience Bulletin

Descrição de um novo método de ooforectomia em ratas

(2012) Deepak Kumar Khajuria et al.   Revista Brasileira De Reumatologia

Regulation of alveolar epithelial cell survival by the ACE-2/angiotensin 1–7/Mas axis

(2011) Bruce D. Uhal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension

(2011) Srinivas Sriramula et al.   CARDIOVASCULAR RESEARCH

Akt signalling in health and disease

(2011) Ingeborg Hers et al.   CELLULAR SIGNALLING

Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke

(2011) Adam P. Mecca et al.   EXPERIMENTAL PHYSIOLOGY

Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection

(2011) Lei Liu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Genetic Approaches to Investigate the Role of CREB in Neuronal Plasticity and Memory

(2011) Angel Barco et al.   MOLECULAR NEUROBIOLOGY

Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

(2011) Jihoon Jo et al.   NATURE NEUROSCIENCE

Angiotensin-(1–7)/Mas axis integrity is required for the expression of object recognition memory

(2011) Thiago L.N. Lazaroni et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

IL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways

(2010) Sushil Sharma et al.   BRAIN RESEARCH

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

(2010) Zheng Li et al.   CELL

Estrogen and angiotensin interaction in the substantia nigra. Relevance to postmenopausal Parkinson's disease

(2010) Ana I. Rodriguez-Perez et al.   EXPERIMENTAL NEUROLOGY

Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension

(2009) Anderson J. Ferreira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Overexpression of Tfam protects mitochondria against β-amyloid-induced oxidative damage in SH-SY5Y cells

(2009) Shangcheng Xu et al.   FEBS Journal

Brain-derived neurotrophic factor in neurodegenerative diseases

(2009) Chiara Zuccato et al.   Nature Reviews Neurology

Nicotinic Acetylcholine Receptor Signalling: Roles in Alzheimer's Disease and Amyloid Neuroprotection

(2009) S. D. Buckingham et al.   PHARMACOLOGICAL REVIEWS

17β-estradiol attenuates glycogen synthase kinase-3β activation and tau hyperphosphorylation in Akt-independent manner

(2008) Hai-Rong Shi et al.   JOURNAL OF NEURAL TRANSMISSION