Hypoxia Affects Neprilysin Expression Through Caspase Activation and an APP Intracellular Domain-dependent Mechanism

γ-Secretase-Mediated Regulation of Neprilysin: Influence of Cell Density and Aging and Modulation by Imatinib

(2018) Charlotte Bauer et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of ageing and experimental diabetes on insulin-degrading enzyme expression in male rat tissues

(2015) Ekaterina G. Kochkina et al.   BIOGERONTOLOGY

Vascular risk factors and Alzheimer’s disease

(2014) John T O’Brien et al.   BMC Medicine

The Aβ-clearance protein transthyretin, like neprilysin, is epigenetically regulated by the amyloid precursor protein intracellular domain

(2014) Caroline Kerridge et al.   JOURNAL OF NEUROCHEMISTRY

Proteomic Identification of Novel Differentiation Plasma Protein Markers in Hypobaric Hypoxia-Induced Rat Model

(2014) Yasmin Ahmad et al.   PLoS One

Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer’s disease

(2014) Natalia N. Nalivaeva et al.   Frontiers in Aging Neuroscience

Endothelin-converting Enzymes Degrade Intracellular β-Amyloid Produced within the Endosomal/Lysosomal Pathway and Autophagosomes

(2013) Javier Pacheco-Quinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of Hypoxia-Inducible Factor by Presenilin/ -Secretase Loss-of-Function Mutations

(2013) M. R. Kaufmann et al.   JOURNAL OF NEUROSCIENCE

Sporadic Alzheimer’s Disease Begins as Episodes of Brain Ischemia and Ischemically Dysregulated Alzheimer’s Disease Genes

(2013) Ryszard Pluta et al.   MOLECULAR NEUROBIOLOGY

Regulation of distinct pools of amyloid β-protein by multiple cellular proteases

(2013) Malcolm A Leissring et al.   Alzheimers Research & Therapy

Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning

(2012) Elena Rybnikova et al.   NEUROSCIENCE RESEARCH

Preventing Alzheimer's Disease

(2012) D. J. Selkoe   SCIENCE

Nuclear signalling by membrane protein intracellular domains: The AICD enigma

(2011) Caroline Beckett et al.   CELLULAR SIGNALLING

Effect of Sodium Valproate Administration on Brain Neprilysin Expression and Memory in Rats

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The physiology of the β-amyloid precursor protein intracellular domain AICD

(2011) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF NEUROCHEMISTRY

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Hypoxia-Induced Down-Regulation of Neprilysin by Histone Modification in Mouse Primary Cortical and Hippocampal Neurons

(2011) Zheng Wang et al.   PLoS One

Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

(2010) Marilee J. Wick et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Diabetes NEP-Like Endopeptidases and Alzheimers Disease

(2010) R.A. Marr et al.   Current Alzheimer Research

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intranasal Phosphoramidon Increases Beta-Amyloid Levels in Wild-Type and NEP/NEP2-Deficient Mice

(2010) Leah R. Hanson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Acute hypoxia promote the phosphorylation of tau via ERK pathway

(2010) Hui Fang et al.   NEUROSCIENCE LETTERS

Novel HTS Strategy Identifies TRAIL-Sensitizing Compounds Acting Specifically Through the Caspase-8 Apoptotic Axis

(2010) Darren Finlay et al.   PLoS One

Pathological role of hypoxia in Alzheimer's disease

(2009) Xin Zhang et al.   EXPERIMENTAL NEUROLOGY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

(2008) Nikolai D Belyaev et al.   EMBO REPORTS

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

(2007) Liang Li et al.   NEUROBIOLOGY OF AGING