Alzheimer’s Amyloid-β is an Antimicrobial Peptide: A Review of the Evidence

Establishment of an Alzheimer’s disease model with latent herpesvirus infection using PS2 and Tg2576 double transgenic mice

(2018) Seiichi Tanaka et al.   EXPERIMENTAL ANIMALS

Identification of Fungal Species in Brain Tissue from Alzheimer’s Disease by Next-Generation Sequencing

(2017) Ruth Alonso et al.   JOURNAL OF ALZHEIMERS DISEASE

Is Periodontal Disease Associated with Alzheimer's Disease? A Systematic Review with Meta-Analysis

(2017) Yago Leira et al.   NEUROEPIDEMIOLOGY

Aggregation of thrombin-derived C-terminal fragments as a previously undisclosed host defense mechanism

(2017) Jitka Petrlova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration

(2017) Qingqing Chai et al.   Nature Communications

16S rRNA Next Generation Sequencing Analysis Shows Bacteria in Alzheimer’s Post-Mortem Brain

(2017) David C. Emery et al.   Frontiers in Aging Neuroscience

Infection and Alzheimer's Disease: The APOE ε4 Connection and Lipid Metabolism

(2017) Nadezda Urosevic et al.   JOURNAL OF ALZHEIMERS DISEASE

Polymicrobial Infections In Brain Tissue From Alzheimer’s Disease Patients

(2017) Diana Pisa et al.   Scientific Reports

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers

(2016) Tomohiro Umeda et al.   BRAIN

Infection in an aging population

(2016) Kimberly A Kline et al.   CURRENT OPINION IN MICROBIOLOGY

Protective Effect of Amyloid-β Peptides Against Herpes Simplex Virus-1 Infection in a Neuronal Cell Culture Model

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-Viral Properties of Amyloid-β Peptides

(2016) Karine Bourgade et al.   JOURNAL OF ALZHEIMERS DISEASE

Bacterial Amyloid and DNA are Important Constituents of Senile Plaques: Further Evidence of the Spirochetal and Biofilm Nature of Senile Plaques

(2016) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Pharmacological Agents Targeting γ-Secretase Increase Risk of Cancer and Cognitive Decline in Alzheimer’s Disease Patients: A Systematic Review and Meta-Analysis

(2016) Ross Penninkilampi et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Cell Adhesion on Amyloid Fibrils Lacking Integrin Recognition Motif

(2016) Reeba S. Jacob et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-associated physiological and pathological changes at the blood–brain barrier: A review

(2016) Franciska Erdő et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Safety and Efficacy of Anti-Amyloid-β Immunotherapy in Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2016) Ross Penninkilampi et al.   Journal of Neuroimmune Pharmacology

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Amyloid-like ribbons of amelogenins in enamel mineralization

(2016) Karina M. M. Carneiro et al.   Scientific Reports

Fungal Enolase, β-Tubulin, and Chitin Are Detected in Brain Tissue from Alzheimer’s Disease Patients

(2016) Diana Pisa et al.   Frontiers in Microbiology

Genes associated with Alzheimer's disease: an overview and current status

(2016) Mohan Giri et al.   Clinical Interventions in Aging

Longipin: An Amyloid Antimicrobial Peptide from the Harvestman Acutisoma longipes (Arachnida: Opiliones) with Preferential Affinity for Anionic Vesicles

(2016) Raphael Santa Rosa Sayegh et al.   PLoS One

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

(2016) Philipp Spitzer et al.   Scientific Reports

Amyloids: from pathogenesis to function

(2015) A. A. Nizhnikov et al.   BIOCHEMISTRY-MOSCOW

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease

(2015) Alaina Baker-Nigh et al.   BRAIN

NET amyloidogenic backbone in human activated neutrophils

(2015) L. Pulze et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Nef exosomes isolated from the plasma of individuals with HIV-associated dementia (HAD) can induce Aβ1–42 secretion in SH-SY5Y neural cells

(2015) Mahfuz B. Khan et al.   JOURNAL OF NEUROVIROLOGY

Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation

(2015) Alice Soragni et al.   MOLECULAR CELL

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Herpes simplex virus type 2 infection induces AD-like neurodegeneration markers in human neuroblastoma cells

(2015) Henrike Kristen et al.   NEUROBIOLOGY OF AGING

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation

(2015) Roberto Piacentini et al.   Scientific Reports

Historic evidence to support a causal relationship between spirochetal infections and Alzheimer’s disease

(2015) Judith Miklossy   Frontiers in Aging Neuroscience

Cerebrospinal Fluid β-Amyloid1–42 Levels in the Differential Diagnosis of Alzheimer’s Disease—Systematic Review and Meta-Analysis

(2015) Jin-A Mo et al.   PLoS One

Different Brain Regions are Infected with Fungi in Alzheimer’s Disease

(2015) Diana Pisa et al.   Scientific Reports

β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

(2014) Karine Bourgade et al.   BIOGERONTOLOGY

Safety profile of semagacestat, a gamma-secretase inhibitor: IDENTITY trial findings

(2014) David B. Henley et al.   CURRENT MEDICAL RESEARCH AND OPINION

A study on the association between infectious burden and Alzheimer's disease

(2014) X.-L. Bu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014

(2014) L. S. Schneider et al.   JOURNAL OF INTERNAL MEDICINE

Alzheimer's Associated β-Amyloid Protein Inhibits Influenza A Virus and Modulates Viral Interactions with Phagocytes

(2014) Mitchell R. White et al.   PLoS One

Detection of bacterial antigens and Alzheimer’s disease-like pathology in the central nervous system of BALB/c mice following intranasal infection with a laboratory isolate of Chlamydia pneumoniae

(2014) Christopher S. Little et al.   Frontiers in Aging Neuroscience

Semen-Derived Enhancer of Viral Infection (SEVI) Binds Bacteria, Enhances Bacterial Phagocytosis by Macrophages, and Can Protect against Vaginal Infection by a Sexually Transmitted Bacterial Pathogen

(2013) David Easterhoff et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The helicase-primase inhibitor BAY 57–1293 reduces the Alzheimer’s disease-related molecules induced by herpes simplex virus type 1

(2013) M.A. Wozniak et al.   ANTIVIRAL RESEARCH

Origins of amyloid-β

(2013) William G Tharp et al.   BMC GENOMICS

Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease

(2013) Yael H. Edrey et al.   NEUROBIOLOGY OF AGING

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid-β and APP Deficiencies Cause Severe Cerebrovascular Defects: Important Work for an Old Villain

(2013) Salvadore Luna et al.   PLoS One

Fluid Biomarkers in Alzheimer Disease

(2013) K. Blennow et al.   Cold Spring Harbor Perspectives in Medicine

Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease

(2012) Vladimir Coric et al.   ARCHIVES OF NEUROLOGY

Neurotoxicity of β-Amyloid Protein: Oligomerization, Channel Formation and Calcium Dyshomeostasis

(2012) Masahiro Kawahara   CURRENT PHARMACEUTICAL DESIGN

Expression and function of APP and its metabolites outside the central nervous system

(2012) Kendra L. Puig et al.   EXPERIMENTAL GERONTOLOGY

A multicenter, blinded, randomized, factorial controlled trial of doxycycline and rifampin for treatment of Alzheimer's disease: the DARAD trial

(2012) D. William Molloy et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Cerebrospinal fluid Alzheimer's biomarker profiles in CNS infections

(2012) Jan Jessen Krut et al.   JOURNAL OF NEUROLOGY

 -Secretase Cleavage of the Fly Amyloid Precursor Protein Is Required for Glial Survival

(2012) B. J. Bolkan et al.   JOURNAL OF NEUROSCIENCE

Exploring New Biological Functions of Amyloids: Bacteria Cell Agglutination Mediated by Host Protein Aggregation

(2012) Marc Torrent et al.   PLoS Pathogens

Antimicrobial Protegrin-1 Forms Amyloid-Like Fibrils with Rapid Kinetics Suggesting a Functional Link

(2011) Hyunbum Jang et al.   BIOPHYSICAL JOURNAL

Testing the Therapeutic Potential of Doxycycline in aDrosophila melanogasterModel of Alzheimer Disease

(2011) Rita Costa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antimicrobial Properties of Amyloid Peptides

(2011) Bruce L. Kagan et al.   MOLECULAR PHARMACEUTICS

Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells

(2011) Soraya Santana et al.   NEUROBIOLOGY OF AGING

A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease

(2011) S. Salloway et al.   NEUROLOGY

Activation of PKR Causes Amyloid ß-Peptide Accumulation via De-Repression of BACE1 Expression

(2011) Gerard ILL-Raga et al.   PLoS One

Antivirals Reduce the Formation of Key Alzheimer's Disease Molecules in Cell Cultures Acutely Infected with Herpes Simplex Virus Type 1

(2011) Matthew A. Wozniak et al.   PLoS One

Statins Enhance Formation of Phagocyte Extracellular Traps

(2010) Ohn A. Chow et al.   Cell Host & Microbe

Five-year Survival After Helicobacter pylori Eradication in Alzheimer Disease Patients

(2010) Jannis Kountouras et al.   Cognitive and Behavioral Neurology

Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes

(2010) Philipp Spitzer et al.   Journal of Neuroinflammation

HSV-1 promotes Ca2+-mediated APP phosphorylation and Aβ accumulation in rat cortical neurons

(2010) Roberto Piacentini et al.   NEUROBIOLOGY OF AGING

Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells

(2010) Walter J. Lukiw et al.   NEUROREPORT

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

APP Processing Induced by Herpes Simplex Virus Type 1 (HSV-1) Yields Several APP Fragments in Human and Rat Neuronal Cells

(2010) Giovanna De Chiara et al.   PLoS One

Amyloid and tau cerebrospinal fluid biomarkers in HIV infection

(2009) Magnus Gisslén et al.   BMC Neurology

Effect of Tarenflurbil on Cognitive Decline and Activities of Daily Living in Patients With Mild Alzheimer DiseaseA Randomized Controlled Trial

(2009) Robert C. Green   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps

(2009) Maren von Köckritz-Blickwede et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HIV Regulation of Amyloid Beta Production

(2009) Lynn Pulliam   Journal of Neuroimmune Pharmacology

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH

Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques

(2008) MA Wozniak et al.   JOURNAL OF PATHOLOGY

Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

(2008) Shida Yousefi et al.   NATURE MEDICINE

Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study

(2008) O. L. Lopez et al.   NEUROLOGY