Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer’s Disease

(2015) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Role of angiotensin-converting enzyme 2/angiotensin-(1–7)/Mas axis in the hypotensive effect of azilsartan

(2014) Jun Iwanami et al.   HYPERTENSION RESEARCH

Conversion of Aβ43 to Aβ40 by the successive action of angiotensin-converting enzyme 2 and angiotensin-converting enzyme

(2014) Shuyu Liu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

(2014) Brice Ongali et al.   NEUROBIOLOGY OF DISEASE

Neuronal over-expression of ACE2 protects brain from ischemia-induced damage

(2014) Ji Chen et al.   NEUROPHARMACOLOGY

Activation of the ACE2/Ang-(1–7)/Mas pathway reduces oxygen–glucose deprivation-induced tissue swelling, ROS production, and cell death in mouse brain with angiotensin II overproduction

(2014) J. Zheng et al.   NEUROSCIENCE

Aβ43 Is the Earliest-Depositing Aβ Species in APP Transgenic Mouse Brain and Is Converted to Aβ41 by Two Active Domains of ACE

(2013) Kun Zou et al.   AMERICAN JOURNAL OF PATHOLOGY

ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke

(2013) Teng Jiang et al.   Current Neuropharmacology

Current status of renin–aldosterone angiotensin system-targeting anti-hypertensive drugs as therapeutic options for Alzheimer's disease

(2013) Emma Louise Ashby et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Suppressing inflammation by inhibiting the NF-κB pathway contributes to the neuroprotective effect of angiotensin-(1-7) in rats with permanent cerebral ischaemia

(2012) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains

(2012) Minjie Tian et al.   FEBS LETTERS

The brain renin–angiotensin system: a diversity of functions and implications for CNS diseases

(2012) John W. Wright et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension

(2011) Srinivas Sriramula et al.   CARDIOVASCULAR RESEARCH

Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke

(2011) Adam P. Mecca et al.   EXPERIMENTAL PHYSIOLOGY

Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease

(2011) Yi-Fei Dong et al.   FASEB JOURNAL

Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimer's disease

(2011) Kazumasa Kume et al.   Geriatrics & Gerontology International

Brain-Selective Overexpression of Angiotensin-Converting Enzyme 2 Attenuates Sympathetic Nerve Activity and Enhances Baroreflex Function in Chronic Heart Failure

(2011) Liang Xiao et al.   HYPERTENSION

Angiotensin-(1–7)/Mas axis integrity is required for the expression of object recognition memory

(2011) Thiago L.N. Lazaroni et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Central Angiotensin II Stimulation Promotes β Amyloid Production in Sprague Dawley Rats

(2011) Donglin Zhu et al.   PLoS One

Brain renin-angiotensin—A new look at an old system

(2011) John W. Wright et al.   PROGRESS IN NEUROBIOLOGY

ACE2/ANG-(1–7)/Mas pathway in the brain: the axis of good

(2010) Ping Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Higher Soluble Amyloid β Concentration in Frontal Cortex of Young Adults than in Normal Elderly or Alzheimer's Disease

(2010) Zoë Van Helmond et al.   BRAIN PATHOLOGY

Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease

(2010) Koji Yamada et al.   BRAIN RESEARCH

Angiotensin-Converting Enzyme 2: Central Regulator for Cardiovascular Function

(2010) Huijing Xia et al.   CURRENT HYPERTENSION REPORTS

Exercise training normalizes ACE and ACE2 in the brain of rabbits with pacing-induced heart failure

(2010) Sumit Kar et al.   JOURNAL OF APPLIED PHYSIOLOGY

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Angiotensin-converting enzyme 2: a new target for neurogenic hypertension

(2009) Yumei Feng et al.   EXPERIMENTAL PHYSIOLOGY

Cognitive Deficit in Amyloid-β–Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-γ Activation

(2009) Kana Tsukuda et al.   HYPERTENSION

Angiotensin II Type 1 Receptor–Mediated Reduction of Angiotensin-Converting Enzyme 2 Activity in the Brain Impairs Baroreflex Function in Hypertensive Mice

(2009) Huijing Xia et al.   HYPERTENSION

Cholinesterase inhibitors may increase phosphorylated tau in Alzheimer’s disease

(2009) Katy A. Chalmers et al.   JOURNAL OF NEUROLOGY

Angiotensin-converting enzyme (ACE) and ACE2 levels in the cerebrospinal fluid of patients with multiple sclerosis

(2009) M Kawajiri et al.   Multiple Sclerosis Journal

Angiotensins in Alzheimer's disease – friend or foe?

(2009) Patrick G. Kehoe et al.   TRENDS IN NEUROSCIENCES

Angiotensin-Converting Enzyme 2 Overexpression in the Subfornical Organ Prevents the Angiotensin II–Mediated Pressor and Drinking Responses and Is Associated With Angiotensin II Type 1 Receptor Downregulation

(2008) Yumei Feng et al.   CIRCULATION RESEARCH

Brain angiotensin-converting enzymes: role of angiotensin-converting enzyme 2 in processing angiotensin II in mice

(2008) Khalid M. Elased et al.   EXPERIMENTAL PHYSIOLOGY

Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis

(2008) Robson A. S. Santos et al.   EXPERIMENTAL PHYSIOLOGY

Increased Expression of Angiotensin Converting Enzyme 2 in Conjunction with Reduction of Neointima by Angiotensin II Type 1 Receptor Blockade

(2008) Michiya IGASE et al.   HYPERTENSION RESEARCH

Brain renin angiotensin in disease

(2008) M. Ian Phillips et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Angiotensin-converting enzyme 2 in the brain: properties and future directions

(2008) Huijing Xia et al.   JOURNAL OF NEUROCHEMISTRY

Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy

(2007) J. S. Miners et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY