Limited Effects of Prolonged Environmental Enrichment on the Pathology of 5XFAD Mice

Long-Term Exercise Modulates Hippocampal Gene Expression in Senescent Female Mice

(2018) María Jesús Alvarez-López et al.   JOURNAL OF ALZHEIMERS DISEASE

Late running is not too late against Alzheimer's pathology

(2016) Arne Herring et al.   NEUROBIOLOGY OF DISEASE

Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer’s disease

(2016) Sylvie L. Lesuis et al.   Oncotarget

Effects of Long-Term Environmental Enrichment on Anxiety, Memory, Hippocampal Plasticity and Overall Brain Gene Expression in C57BL6 Mice

(2016) Melanie Hüttenrauch et al.   Frontiers in Molecular Neuroscience

Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia

(2015) Anna-Maija Tolppanen et al.   Alzheimers & Dementia

Differential proteomic and behavioral effects of long-term voluntary exercise in wild-type and APP-overexpressing transgenics

(2015) Shailaja Kishan Rao et al.   NEUROBIOLOGY OF DISEASE

The Link Between Physical Activity and Cognitive Dysfunction in Alzheimer Disease

(2015) C. Phillips et al.   PHYSICAL THERAPY

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice

(2014) Sung Wook Park et al.   NEUROBIOLOGY OF AGING

Galantamine Slows Down Plaque Formation and Behavioral Decline in the 5XFAD Mouse Model of Alzheimer’s Disease

(2014) Soumee Bhattacharya et al.   PLoS One

Deciphering the Molecular Profile of Plaques, Memory Decline and Neuron Loss in Two Mouse Models for Alzheimer’s Disease by Deep Sequencing

(2014) Yvonne Bouter et al.   Frontiers in Aging Neuroscience

Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice

(2013) Eun-Bum Kang et al.   APOPTOSIS

Voluntary exercise counteracts Aβ25-35-induced memory impairment in mice

(2013) Qin Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Long-term treadmill exercise inhibits the progression of Alzheimer's disease-like neuropathology in the hippocampus of APP/PS1 transgenic mice

(2013) Hui-li Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Microglial response to Alzheimer’s disease is differentially modulated by voluntary wheel running and enriched environments

(2013) J. J. Rodríguez et al.   Brain Structure & Function

Treadmill Exercise Prevents Learning and Memory Impairment in Alzheimer’s Disease-Like Pathology

(2013) An T. Dao et al.   Current Alzheimer Research

Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

(2013) William A Eimer et al.   Molecular Neurodegeneration

Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease

(2013) Anika Saul et al.   NEUROBIOLOGY OF AGING

Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

(2013) Céline Héraud et al.   NEUROBIOLOGY OF DISEASE

Early Enriched Environment Exposure Protects Spatial Memory and Accelerates Amyloid Plaque Formation in APPSwe/PS1L166P Mice

(2013) Francesca Montarolo et al.   PLoS One

Enriched environment and physical activity reverse astrogliodegeneration in the hippocampus of AD transgenic mice

(2013) J J Rodríguez et al.   Cell Death & Disease

Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease

(2012) Juan Beauquis et al.   EXPERIMENTAL NEUROLOGY

Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease

(2012) Jessica L. Wittnam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intraneuronal Aβ accumulation and neurodegeneration: Lessons from transgenic models

(2012) Oliver Wirths et al.   LIFE SCIENCES

Transient enriched housing before amyloidosis onset sustains cognitive improvement in Tg2576 mice

(2012) Laure Verret et al.   NEUROBIOLOGY OF AGING

Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise

(2011) Hsing-Chieh Ke et al.   BRAIN RESEARCH

No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease

(2011) Antje Hillmann et al.   NEUROBIOLOGY OF AGING

Physical Activity and Alzheimer Disease Course

(2010) Nikolaos Scarmeas et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation

(2010) Hui-li Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer’s disease-linked APPswe/PS1ΔE9 mice

(2010) Yuan-Shih Hu et al.   FASEB JOURNAL

Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure

(2010) Stefanie Hahn et al.   JOURNAL OF NEUROCHEMISTRY

Environmental enrichment fails to rescue working memory deficits, neuron loss, and neurogenesis in APP/PS1KI mice

(2010) Marie-Caroline Cotel et al.   NEUROBIOLOGY OF AGING

Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease

(2010) Sadim Jawhar et al.   NEUROBIOLOGY OF AGING

Exercise improves cognition and hippocampal plasticity in APOE ε4 mice

(2009) Kathryn Nichol et al.   Alzheimers & Dementia

Transgenic Alzheimer mice in a semi-naturalistic environment: More plaques, yet not compromised in daily life

(2009) Lars Lewejohann et al.   BEHAVIOURAL BRAIN RESEARCH

Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease

(2009) S. Peng et al.   JOURNAL OF NEUROSCIENCE

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease

(2009) Carla M. Yuede et al.   NEUROBIOLOGY OF DISEASE

Wheel-running in a transgenic mouse model of Alzheimer's disease: Protection or symptom?

(2008) Helene Richter et al.   BEHAVIOURAL BRAIN RESEARCH

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

(2008) Kathryn E Nichol et al.   Journal of Neuroinflammation

Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition

(2008) A. Parachikova et al.   NEUROBIOLOGY OF DISEASE