Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance

Accumulation of Insoluble Amyloid-β in Down's Syndrome is Associated with Increased BACE-1 and Neprilysin Activities

(2018) James Scott Miners et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered NEP2 Expression and Activity in Mild Cognitive Impairment and Alzheimer's Disease

(2018) Jeffrey Y. Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Following Activation of the Amyloid Cascade, Apolipoprotein E4 Drives the in vivo Oligomerization of Amyloid-β Resulting in Neurodegeneration

(2017) Haim Belinson et al.   JOURNAL OF ALZHEIMERS DISEASE

The dark sides of amyloid in Alzheimer's disease pathogenesis

(2014) Pierpaolo Sorrentino et al.   FEBS LETTERS

Plasma phospholipids identify antecedent memory impairment in older adults

(2014) Mark Mapstone et al.   NATURE MEDICINE

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Systematic Review of Biomarkers for Disease Progression in Alzheimer's Disease

(2014) David J. M. McGhee et al.   PLoS One

History of Medically Treated Diabetes and Risk of Alzheimer Disease in a Nationwide Case-Control Study

(2013) A.-M. Tolppanen et al.   DIABETES CARE

Midlife cardiovascular risk factors and late cognitive impairment

(2013) Jyri J. Virta et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4, and the Risk of Late-Onset Alzheimer Disease in African Americans

(2013) Christiane Reitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Deletion of Abca7 Increases Cerebral Amyloid-  Accumulation in the J20 Mouse Model of Alzheimer's Disease

(2013) W. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Bapineuzumab Alters Aβ Composition: Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy

(2013) Alex E. Roher et al.   PLoS One

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease

(2012) Martin Farlow et al.   Alzheimers & Dementia

Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

(2012) Daniela Kaden et al.   EMBO Molecular Medicine

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

(2012) T. Hashimoto et al.   JOURNAL OF NEUROSCIENCE

Development of Vascular Risk Factors over 15 Years in Relation to Cognition: The Hoorn Study

(2012) Yael D. Reijmer et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Peripheral Mitochondrial Dysfunction in Alzheimer’s Disease: Focus on Lymphocytes

(2012) Kristina Leuner et al.   MOLECULAR NEUROBIOLOGY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory

(2012) Daniela Puzzo et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E, amyloid-ß clearance and therapeutic opportunities in Alzheimer's disease

(2012) Adam Kline   Alzheimers Research & Therapy

Neprilysin-2 Is an Important β-Amyloid Degrading Enzyme

(2011) Daniel Hafez et al.   AMERICAN JOURNAL OF PATHOLOGY

Preclinical Biomarkers of Parkinson Disease

(2011) Yuncheng Wu et al.   ARCHIVES OF NEUROLOGY

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Aβ-Degrading Enzymes: Potential for Treatment of Alzheimer Disease

(2011) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Heavy Smoking in Midlife and Long-term Risk of Alzheimer Disease and Vascular Dementia

(2010) Minna Rusanen et al.   ARCHIVES OF INTERNAL MEDICINE

Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme

(2010) J. Scott Miners et al.   BRAIN PATHOLOGY

Diabetes NEP-Like Endopeptidases and Alzheimers Disease

(2010) R.A. Marr et al.   Current Alzheimer Research

Intranasal Phosphoramidon Increases Beta-Amyloid Levels in Wild-Type and NEP/NEP2-Deficient Mice

(2010) Leah R. Hanson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Expression and functional profiling of neprilysin, insulin-degrading enzyme, and endothelin-converting enzyme in prospectively studied elderly and Alzheimer’s brain

(2010) Suqing Wang et al.   JOURNAL OF NEUROCHEMISTRY

Transcriptome profiling in neurodegenerative disease

(2010) Eliza Courtney et al.   JOURNAL OF NEUROSCIENCE METHODS

The Effect of Midlife Physical Activity on Cognitive Function Among Older Adults: AGES—Reykjavik Study

(2010) Milan Chang et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity

(2009) James Scott Miners et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Picomolar Amyloid-  Positively Modulates Synaptic Plasticity and Memory in Hippocampus

(2009) D. Puzzo et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

The influence of age on the association between cholesterol and cognitive function

(2008) Peter van Vliet et al.   EXPERIMENTAL GERONTOLOGY

Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences

(2008) Alison R. Whyteside et al.   FEBS LETTERS

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dynamics of A  Turnover and Deposition in Different  -Amyloid Precursor Protein Transgenic Mouse Models Following  -Secretase Inhibition

(2008) D. Abramowski et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation of the Amyloid Cascade by Intracerebroventricular Injection of the Protease Inhibitor Phosphoramidon

(2008) Yotam Nisemblat et al.   Neurodegenerative Diseases

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40

(2008) J.Y. Huang et al.   NEUROSCIENCE