A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

Reduced Cardiovascular Functions in Patients with Alzheimer’s Disease

(2017) Wang-Sheng Jin et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered peripheral profile of blood cells in Alzheimer disease

(2017) Si-Han Chen et al.   MEDICINE

Molecular interaction between type 2 diabetes and Alzheimer’s disease through cross-seeding of protein misfolding

(2017) I Moreno-Gonzalez et al.   MOLECULAR PSYCHIATRY

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

(2017) Joseph M. Castellano et al.   NATURE

Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease

(2017) Jonathan Cedernaes et al.   SLEEP MEDICINE REVIEWS

Metabolism-Centric Overview of the Pathogenesis of Alzheimer's Disease

(2017) Somang Kang et al.   YONSEI MEDICAL JOURNAL

A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012

(2017) Kenneth M. Langa et al.   JAMA Internal Medicine

Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

(2017) Julie M. Zissimopoulos et al.   JAMA Neurology

Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease

(2017) Niklas Mattsson et al.   JAMA Neurology

Tau oligomers in cerebrospinal fluid in Alzheimer's disease

(2017) Urmi Sengupta et al.   Annals of Clinical and Translational Neurology

Innate phagocytosis by peripheral blood monocytes is altered in Alzheimer’s disease

(2016) Ben J. Gu et al.   ACTA NEUROPATHOLOGICA

Could Better Phenotyping Small Vessel Disease Provide New Insights into Alzheimer Disease and Improve Clinical Trial Outcomes?

(2016) Michael Marnane et al.   Current Alzheimer Research

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Chronic cerebral hypoperfusion induces memory deficits and facilitates Aβ generation in C57BL/6J mice

(2016) Lingxi Wang et al.   EXPERIMENTAL NEUROLOGY

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Patients that have Undergone Hemodialysis Exhibit Lower Amyloid Deposition in the Brain: Evidence Supporting a Therapeutic Strategy for Alzheimer’s Disease by Removal of Blood Amyloid

(2016) Kazuyoshi Sakai et al.   JOURNAL OF ALZHEIMERS DISEASE

Associations between Serum Omega-3 Fatty Acid Levels and Cognitive Functions among Community-Dwelling Octogenarians in Okinawa, Japan: The KOCOA Study

(2016) Junko Nishihira et al.   JOURNAL OF ALZHEIMERS DISEASE

Rapid in vivo measurement of β-amyloid reveals biphasic clearance kinetics in an Alzheimer’s mouse model

(2016) Carla M. Yuede et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aβ Amyloid Pathology Affects the Hearts of Patients With Alzheimer’s Disease

(2016) Luca Troncone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dementia in western Europe: epidemiological evidence and implications for policy making

(2016) Yu-Tzu Wu et al.   LANCET NEUROLOGY

Associations Between Hepatic Functions and Plasma Amyloid-Beta Levels—Implications for the Capacity of Liver in Peripheral Amyloid-Beta Clearance

(2016) Ye-Ran Wang et al.   MOLECULAR NEUROBIOLOGY

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease

(2016) Kuti Baruch et al.   NATURE MEDICINE

Biomarkers of AD risk — the end of the road for plasma amyloid-β?

(2016) Heather Wood   Nature Reviews Neurology

Dementia risk in renal dysfunction

(2016) Kay Deckers et al.   NEUROLOGY

Plasma tau in Alzheimer disease

(2016) Niklas Mattsson et al.   NEUROLOGY

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin

(2016) Teng Wang et al.   NEUROPHARMACOLOGY

Incidence of Dementia over Three Decades in the Framingham Heart Study

(2016) Claudia L. Satizabal et al.   NEW ENGLAND JOURNAL OF MEDICINE

The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function

(2016) Samuel E. Marsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

The Association Between Obstructive Sleep Apnea and Alzheimer’s Disease: A Meta-Analysis Perspective

(2016) Farnoosh Emamian et al.   Frontiers in Aging Neuroscience

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

(2016) Elmira Akbari et al.   Frontiers in Aging Neuroscience

Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis

(2016) Hussein N. Yassine et al.   JAMA Neurology

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

(2016) Jinte Middeldorp et al.   JAMA Neurology

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease

(2015) Yang Xiang et al.   ACTA NEUROPATHOLOGICA

Human Umbilical Cord Blood-Derived Monocytes Improve Cognitive Deficits and Reduce Amyloid-β Pathology in PSAPP Mice

(2015) Donna Darlington et al.   CELL TRANSPLANTATION

Low Cardiac Index Is Associated With Incident Dementia and Alzheimer Disease: The Framingham Heart Study

(2015) A. L. Jefferson et al.   CIRCULATION

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice

(2015) Stefan Prokop et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Implications of the discovery of brain lymphatic pathways

(2015) Jeffrey J Iliff et al.   LANCET NEUROLOGY

Factors Responsible for Plasma β-Amyloid Accumulation in Chronic Kidney Disease

(2015) Janine Gronewold et al.   MOLECULAR NEUROBIOLOGY

p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease

(2015) X-Q Yao et al.   MOLECULAR PSYCHIATRY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

(2015) Zane Jaunmuktane et al.   NATURE

Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin

(2015) Elena Zenaro et al.   NATURE MEDICINE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Sleep-disordered breathing advances cognitive decline in the elderly

(2015) R. S. Osorio et al.   NEUROLOGY

Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease

(2015) Xian-Le Bu et al.   NEUROTOXICITY RESEARCH

Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology

(2015) Kuti Baruch et al.   Nature Communications

Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome

(2015) Xian-Le Bu et al.   Scientific Reports

The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease

(2015) Naoyuki Sato et al.   Frontiers in Aging Neuroscience

Sleep apnoea and the brain: a complex relationship

(2015) Ivana Rosenzweig et al.   Lancet Respiratory Medicine

A platelet protein biochip rapidly detects an Alzheimer’s disease-specific phenotype

(2014) Michael Veitinger et al.   ACTA NEUROPATHOLOGICA

Apolipoprotein E in Alzheimer's Disease: An Update

(2014) Jin-Tai Yu et al.   Annual Review of Neuroscience

Amyloid beta peptide is elevated in osteoporotic bone tissues and enhances osteoclast function

(2014) Shangfu Li et al.   BONE

Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer’s disease and mild cognitive impairment

(2014) Niklas Mattsson et al.   BRAIN

Brain Changes Underlying Cognitive Dysfunction in Diabetes: What Can We Learn From MRI?

(2014) G. J. Biessels et al.   DIABETES

A study on the association between infectious burden and Alzheimer's disease

(2014) X.-L. Bu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Investigational drugs in Alzheimer's disease: current progress

(2014) Camryn Berk et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Heart failure and Alzheimer′s disease

(2014) P. Cermakova et al.   JOURNAL OF INTERNAL MEDICINE

Multiple Factors Contribute to the Peripheral Induction of Cerebral  -Amyloidosis

(2014) Y. S. Eisele et al.   JOURNAL OF NEUROSCIENCE

Clearance of Amyloid-Beta in Alzheimer’s Disease: Shifting the Action Site from Center to Periphery

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

Association Between Serum Amyloid-Beta and Renal Functions: Implications for Roles of Kidney in Amyloid-Beta Clearance

(2014) Yu-Hui Liu et al.   MOLECULAR NEUROBIOLOGY

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

(2014) Saul A Villeda et al.   NATURE MEDICINE

Lessons from immunotherapy for Alzheimer disease

(2014) Yan-Jiang Wang   Nature Reviews Neurology

The interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals

(2014) Ricardo S. Osorio et al.   NEUROBIOLOGY OF AGING

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

(2014) Hisham Qosa et al.   NEUROPHARMACOLOGY

Can sleep apnea cause Alzheimer's disease?

(2014) Weihong Pan et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

(2014) L. Katsimpardi et al.   SCIENCE

The low-density lipoprotein receptor-related protein 1 and amyloid-β clearance in Alzheimer’s disease

(2014) Takahisa Kanekiyo et al.   Frontiers in Aging Neuroscience

Associations Between Cerebral Small-Vessel Disease and Alzheimer Disease Pathology as Measured by Cerebrospinal Fluid Biomarkers

(2014) Maartje I. Kester et al.   JAMA Neurology

Statins and Cognitive Function

(2013) Karl Richardson et al.   ANNALS OF INTERNAL MEDICINE

Growth Differentiation Factor 11 Is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy

(2013) Francesco S. Loffredo et al.   CELL

Immunity and Alzheimer's disease: immunological perspectives on the development of novel therapies

(2013) Yu-Hui Liu et al.   DRUG DISCOVERY TODAY

The platelet amyloid precursor protein ratio as a diagnostic marker for Alzheimer’s disease in Thai patients

(2013) Chatchawan Srisawat et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Systemic immune system alterations in early stages of Alzheimer's disease

(2013) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

A blood-based predictor for neocortical Aβ burden in Alzheimer’s disease: results from the AIBL study

(2013) S C Burnham et al.   MOLECULAR PSYCHIATRY

Differential processing of amyloid precursor protein in brain and in peripheral blood leukocytes

(2013) Elaine Delvaux et al.   NEUROBIOLOGY OF AGING

Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice

(2013) Panayiota Papadopoulos et al.   NEUROBIOLOGY OF AGING

New Insights into the Dementia Epidemic

(2013) Eric B. Larson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

(2013) Grietje Krabbe et al.   PLoS One

A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid

(2013) Adrianna Z. Herskovits et al.   PLoS One

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer’s-like disease progression

(2013) Dan Frenkel et al.   Nature Communications

Associations Between Serum Cholesterol Levels and Cerebral Amyloidosis

(2013) Bruce Reed et al.   JAMA Neurology

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease

(2012) James D. Doecke   ARCHIVES OF NEUROLOGY

Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament

(2012) Ales Bartos et al.   JOURNAL OF NEUROIMMUNOLOGY

Alzheimer’s Disease in the Retina: Imaging Retinal Aß Plaques for Early Diagnosis and Therapy Assessment

(2012) Yosef Koronyo et al.   Neurodegenerative Diseases

Association of Alzheimer Disease Pathology with Abnormal Lipid Metabolism: The Hisayama Study

(2012) G. T. Lesser   NEUROLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

(2012) N. Sehgal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral hypoperfusion accelerates cerebral amyloid angiopathy and promotes cortical microinfarcts

(2011) Yoko Okamoto et al.   ACTA NEUROPATHOLOGICA

Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI

(2011) Jon B. Toledo et al.   ACTA NEUROPATHOLOGICA

Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels

(2011) C. Y. Daniel Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease

(2011) J. Li et al.   NEUROLOGY

Hypoxia Due to Cardiac Arrest Induces a Time-Dependent Increase in Serum Amyloid β Levels in Humans

(2011) Henrik Zetterberg et al.   PLoS One

Risk of developing dementia in people with diabetes and mild cognitive impairment

(2010) Latha Velayudhan et al.   BRITISH JOURNAL OF PSYCHIATRY

Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseases

(2010) C. E. Teunissen et al.   EUROPEAN JOURNAL OF NEUROLOGY

N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly

(2010) Mei-Chen Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum levels of S100B and NSE proteins in Alzheimer's disease patients

(2010) Márcia L Chaves et al.   Journal of Neuroinflammation

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Peripherally Applied A -Containing Inoculates Induce Cerebral  -Amyloidosis

(2010) Y. S. Eisele et al.   SCIENCE

Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy

(2009) Justin Zaghi et al.   ACTA NEUROPATHOLOGICA

Amyloid-targeted therapeutics in Alzheimer's disease: Use of human albumin in plasma exchange as a novel approach for abeta mobilization

(2009) M. Boada et al.   DRUG NEWS & PERSPECTIVES

Cause of death in patients with dementia disorders

(2009) H. R. Brunnström et al.   EUROPEAN JOURNAL OF NEUROLOGY

Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization

(2009) Megan M. Murray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expression of Neprilysin in Skeletal Muscle Reduces Amyloid Burden in a Transgenic Mouse Model of Alzheimer Disease

(2009) Yinxing Liu et al.   MOLECULAR THERAPY

Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease

(2008) Alex E. Roher et al.   Alzheimers & Dementia

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study

(2008) M D M Haag et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cognitive Effects of Treating Obstructive Sleep Apnea in Alzheimer's Disease: A Randomized Controlled Study

(2008) Sonia Ancoli-Israel et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY