Recent Expansions on Cellular Models to Uncover the Scientific Barriers Towards Drug Development for Alzheimer’s Disease

Regulatory effects of simvastatin and apoJ on APP processing and amyloid-β clearance in blood-brain barrier endothelial cells

(2018) Martina Zandl-Lang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Functional characterization of α7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay

(2018) Mohamed R. Elnagar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease

(2018) Fangfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Recent advancements in the field of nanotechnology for the delivery of anti-Alzheimer drug in the brain region

(2018) Mukta Agrawal et al.   Expert Opinion on Drug Delivery

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

(2018) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

Enfermedad de Alzheimer de inicio precoz y de inicio tardío: ¿son la misma entidad?

(2018) P. Tellechea et al.   NEUROLOGIA

Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells

(2018) Yuanwei Yan et al.   TISSUE ENGINEERING PART A

Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease

(2018) Mehdi Jorfi et al.   Scientific Reports

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization

(2018) Elena Sánchez-López et al.   JOURNAL OF NANOBIOTECHNOLOGY

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease

(2018) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Paradoxical Effect of TrkA Inhibition in Alzheimer's Disease Models

(2018) Qiang Zhang et al.   JOURNAL OF ALZHEIMERS DISEASE

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

Current Status of Stem Cell Therapies in Tissue Repair and Regeneration

(2018) Tapan Kumar Giri et al.   Current Stem Cell Research & Therapy

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

(2017) Marie Jouanne et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synaptic dysfunction in Alzheimer's disease: From the role of amyloid β-peptide to the α-secretase ADAM10

(2017) Stefano Musardo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effect of cinnamaldehyde against glutamate-induced oxidative stress and apoptosis in PC12 cells

(2017) Chao Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The present and future of pharmacotherapy of Alzheimer’s disease: A comprehensive review

(2017) Abhinav Anand et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin

(2017) Yung-Chih Kuo et al.   International Journal of Nanomedicine

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent advancements in liposomes targeting strategies to cross blood-brain barrier (BBB) for the treatment of Alzheimer's disease

(2017) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges

(2017) Anna Poon et al.   New Biotechnology

Antioxidant activity against H2O2-induced cytotoxicity of the ethanol extract and compounds from Pyrola decorate leaves

(2017) Xiliang Yang et al.   PHARMACEUTICAL BIOLOGY

Adiponectin controls the apoptosis and the expression of tight junction proteins in brain endothelial cells through AdipoR1 under beta amyloid toxicity

(2017) Juhyun Song et al.   Cell Death & Disease

Systemic clearance and brain distribution of carbazole-based cyanine compounds as Alzheimer’s disease drug candidates

(2017) Wei Zhou et al.   Scientific Reports

A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism

(2017) Daniel Daugherty et al.   Alzheimers Research & Therapy

Stem cell models of Alzheimer’s disease: progress and challenges

(2017) Charles Arber et al.   Alzheimers Research & Therapy

Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease

(2017) Rui Li et al.   Protein & Cell

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

Identification of two immortalized cell lines, ECV304 and bEnd3, for in vitro permeability studies of blood-brain barrier

(2017) Shu Yang et al.   PLoS One

Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern

(2017) Sai Kang et al.   Scientific Reports

Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases

(2016) Kelly M. Haston et al.   Annual Review of Pharmacology and Toxicology

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Stem Cells Expand Insights into Human Brain Evolution

(2016) Michael A. Dyer   Cell Stem Cell

Alzheimer's disease: Targeting the Cholinergic System

(2016) Talita H. Ferreira-Vieira et al.   Current Neuropharmacology

High-Throughput Screening for Identification of Blood-Brain Barrier Integrity Enhancers: A Drug Repurposing Opportunity to Rectify Vascular Amyloid Toxicity

(2016) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Recent expansion of pharmaceutical nanotechnologies and targeting strategies in the field of phytopharmaceuticals for the delivery of herbal extracts and bioactives

(2016) Amit Alexander et al.   JOURNAL OF CONTROLLED RELEASE

A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent

(2016) Tae Ho Lee et al.   JOURNAL OF NEUROCHEMISTRY

Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood-brain barrier

(2016) Elisanne A.L.M. Biemans et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells

(2016) Alison E. Mungenast et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

(2016) Se Hoon Choi et al.   Molecular Neurodegeneration

Wnt / ß-Catenin Signaling Pathway Against Aβ Toxicity in PC12 Cells

(2016) Yaping Zheng et al.   NEUROSIGNALS

Leptin Regulates Tau Phosphorylation through Wnt Signaling Pathway in PC12 Cells

(2016) Zijuan Zhang et al.   NEUROSIGNALS

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis

(2016) Priya Pal et al.   mBio

The aqueous extract of Glycyrrhiza inflata can upregulate unfolded protein response-mediated chaperones to reduce tau misfolding in cell models of Alzheimer’s disease

(2016) Guey-Jen Lee-Chen et al.   Drug Design Development and Therapy

Puerarin transport across a Calu-3 cell monolayer – an in vitro model of nasal mucosa permeability and the influence of paeoniflorin and menthol

(2016) Lin Zhang et al.   Drug Design Development and Therapy

Understanding the Role of Poloxamer 407 based Thermoreversible In Situ Gelling Hydrogel for Delivery of PEGylated Melphalan Conjugate

(2016) Amit Alexander et al.   Current Drug Delivery

Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins

(2016) Hayato Fukusumi et al.   Stem Cells International

Human Brain Microvascular Endothelial Cells Derived from the BC1 iPS Cell Line Exhibit a Blood-Brain Barrier Phenotype

(2016) Moriah E. Katt et al.   PLoS One

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

(2016) Han-Kyu Lee et al.   PLoS One

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

(2016) Rachelle Balez et al.   Scientific Reports

A herbal medicine for Alzheimer's disease and its active constituents promote neural progenitor proliferation

(2015) Jianxin Mao et al.   AGING CELL

In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

(2015) Pietra Candela et al.   BRAIN RESEARCH

A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease

(2015) Fanfei Meng et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Role of Environmental Contaminants in the Etiology of Alzheimer’s Disease: A Review

(2015) Manivannan Yegambaram et al.   Current Alzheimer Research

Blood brain barrier precludes the cerebral arteries to intravenously-injected antisense oligonucleotide

(2015) Raphael Boursereau et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oleic acid increases mitochondrial reactive oxygen species production and decreases endothelial nitric oxide synthase activity in cultured endothelial cells

(2015) Hendrik Gremmels et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Reducing Aβ load and tau phosphorylation: Emerging perspective for treating Alzheimer's disease

(2015) Jaspreet Kalra et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Chitosan as a suitable nanocarrier material for anti-Alzheimer drug delivery

(2015) Jayrajsinh Sarvaiya et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Truncated Amyloid-β(11–40/42)from Alzheimer Disease Binds Cu2+with a Femtomolar Affinity and Influences Fiber Assembly

(2015) Joseph D. Barritt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanomolar aluminum induces expression of the inflammatory systemic biomarker C-reactive protein (CRP) in human brain microvessel endothelial cells (hBMECs)

(2015) Peter N. Alexandrov et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

In Vitro Blood–Brain Barrier Models—An Overview of Established Models and New Microfluidic Approaches

(2015) Anette Wolff et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Intranasal H102 Peptide-Loaded Liposomes for Brain Delivery to Treat Alzheimer’s Disease

(2015) Xiaoyao Zheng et al.   PHARMACEUTICAL RESEARCH

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

A chemically defined substrate for the expansion and neuronal differentiation of human pluripotent stem cell-derived neural progenitor cells

(2015) Yihuan Tsai et al.   Stem Cell Research

Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons

(2015) K Nieweg et al.   Cell Death & Disease

Glyceraldehyde caused Alzheimer’s disease-like alterations in diagnostic marker levels in SH-SY5Y human neuroblastoma cells

(2015) Yoshiki Koriyama et al.   Scientific Reports

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

(2015) Anil Kumar et al.   Frontiers in Pharmacology

Quercetin protects human brain microvascular endothelial cells from fibrillar β-amyloid1–40-induced toxicity

(2015) Yongjie Li et al.   Acta Pharmaceutica Sinica B

Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease

(2015) Abhimanyu Krishna et al.   BMC GENOMICS

Loss of proteostasis induced by amyloid beta peptide in brain endothelial cells

(2014) Ana Catarina Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Protection of SK-N-MC cells against β-amyloid peptide-induced degeneration using neuron growth factor-loaded liposomes with surface lactoferrin

(2014) Yung-Chih Kuo et al.   BIOMATERIALS

The multi-functional drug tropisetron binds APP and normalizes cognition in a murine Alzheimer's model

(2014) Patricia Spilman et al.   BRAIN RESEARCH

Intranasal Delivery of Bone Marrow-Derived Mesenchymal Stem Cells, Macrophages, and Microglia to the Brain in Mouse Models of Alzheimer's and Parkinson's Disease

(2014) Lusine Danielyan et al.   CELL TRANSPLANTATION

Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy

(2014) Ryan C. McCarthy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Polyethylene glycol (PEG)–Poly(N-isopropylacrylamide) (PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications

(2014) Amit Alexander et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

(2014) Miguel Alejandro Lopez-Ramirez et al.   FASEB JOURNAL

The Spleen Tyrosine Kinase (Syk) Regulates Alzheimer Amyloid-β Production and Tau Hyperphosphorylation

(2014) Daniel Paris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer Disease and Cellular Mechanisms of Memory Storage

(2014) Yuri I. Arshavsky   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Formulation and evaluation of chitosan-based long-acting injectable hydrogel for PEGylated melphalan conjugate

(2014) Amit Alexander et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death

(2014) Lishu Duan et al.   Molecular Neurodegeneration

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Glial Cell Ceruloplasmin and Hepcidin Differentially Regulate Iron Efflux from Brain Microvascular Endothelial Cells

(2014) Ryan C. McCarthy et al.   PLoS One

A Novel Blood-Brain Barrier Co-Culture System for Drug Targeting of Alzheimer’s Disease: Establishment by Using Acitretin as a Model Drug

(2014) Christian Freese et al.   PLoS One

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

(2014) Andrew A. Sproul et al.   PLoS One

Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling

(2014) Kazuhide Hayakawa et al.   Stem Cell Research

Cell-Culture Models of the Blood–Brain Barrier

(2014) Yarong He et al.   STROKE

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

Aβ1–42 reduces P-glycoprotein in the blood–brain barrier through RAGE–NF-κB signaling

(2014) R Park et al.   Cell Death & Disease

Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations

(2014) Yao-Cheng Lin et al.   Nature Communications

Dissecting gene expression at the blood-brain barrier

(2014) Melanie A. Huntley et al.   Frontiers in Neuroscience

Setting-up an In Vitro Model of Rat Blood-brain Barrier (BBB): A Focus on BBB Impermeability and Receptor-mediated Transport

(2014) Yves Molino et al.   Jove-Journal of Visualized Experiments

Tau-aggregation inhibitor therapy for Alzheimer's disease

(2013) Claude M. Wischik et al.   BIOCHEMICAL PHARMACOLOGY

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons

(2013) Dawei Zhang et al.   BIOMATERIALS

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

(2013) Matthew Brentnall et al.   BMC CELL BIOLOGY

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

(2013) Zaira Esposito et al.   CNS Neuroscience & Therapeutics

Guggulsterone regulates the function and expression of P-glycoprotein in rat brain microvessel endothelial cells

(2013) Xian-Zhen Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dyad of CD40/CD40 Ligand Fosters Neuroinflammation at the Blood-Brain Barrier and Is Regulated via JNK Signaling: Implications for HIV-1 Encephalitis

(2013) S. H. Ramirez et al.   JOURNAL OF NEUROSCIENCE

Kinetic Analysis of the Toxicity of Pharmaceutical Excipients Cremophor EL and RH40 on Endothelial and Epithelial Cells

(2013) Lóránd Kiss et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Isolation and expansion of human and mouse brain microvascular endothelial cells

(2013) Stefania E Navone et al.   Nature Protocols

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Inhibition of the SK-N-MC human neuroblastoma cell line in vivo and in vitro by a novel nutrient mixture

(2013) M. WAHEED ROOMI et al.   ONCOLOGY REPORTS

Neuroprotective Effect of Ginkgolide B on Bupivacaine-Induced Apoptosis in SH-SY5Y Cells

(2013) Le Li et al.   Oxidative Medicine and Cellular Longevity

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Should EOAD patients be included in clinical trials?

(2013) Kinga Szigeti et al.   Alzheimers Research & Therapy

Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration

(2013) E.-M. Mandelkow et al.   Cold Spring Harbor Perspectives in Medicine

Cilostazol Strengthens Barrier Integrity in Brain Endothelial Cells

(2012) Shoji Horai et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Inhibition of H2O2-induced cell death through FOXO1 modulation by EUK-172 in SK-N-MC cells

(2012) Ali Gheysarzadeh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

(2012) Ankita Mehta et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

(2012) Matthew R. Durk et al.   JOURNAL OF NEUROCHEMISTRY

Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier

(2012) Brian P. Daniels et al.   JOURNAL OF NEUROSCIENCE METHODS

Multi-target, Neuroprotective and Neurorestorative M30 Improves Cognitive Impairment and Reduces Alzheimer's-Like Neuropathology and Age-Related Alterations in Mice

(2012) Lana Kupershmidt et al.   MOLECULAR NEUROBIOLOGY

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes

(2012) Matthias Cacquevel et al.   PLoS One

Human Pluripotent Stem Cells: Applications and Challenges in Neurological Diseases

(2012) Youssef Hibaoui et al.   Frontiers in Physiology

Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: The case for isradipine

(2011) Thimmappa S. Anekonda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Effect of human astrocytes on the characteristics of human brain-microvascular endothelial cells in the blood–brain barrier

(2011) Yung-Chih Kuo et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Impact of induced pluripotent stem cells on the study of central nervous system disease

(2011) Paige E Cundiff et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood–brain barrier

(2011) Corbin Bachmeier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anatabine lowers Alzheimer's Aβ production in vitro and in vivo

(2011) Daniel Paris et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway

(2011) Tada-aki Kudo et al.   GENES TO CELLS

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

The effect of rosiglitazone on LRP1 expression and amyloid β uptake in human brain microvascular endothelial cells: a possible role of a low-dose thiazolidinedione for dementia treatment

(2011) Jae Hoon Moon et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Radiation-triggered Tumor Necrosis Factor (TNF) α-NFκB Cross-signaling Favors Survival Advantage in Human Neuroblastoma Cells

(2011) Jamunarani Veeraraghavan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unknown

(2011) Adriana Ferreira et al.   MOLECULAR MEDICINE

Unknown

(2011) Daniel Paris et al.   MOLECULAR MEDICINE

Susceptibility of human primary neuronal cells to Xenotropic Murine Leukemia Virus-related (XMRV) virus infection

(2011) Veerasamy Ravichandran et al.   Virology Journal

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Inhibition of Glycogen Synthase Kinase 3β (GSK3β) Decreases Inflammatory Responses in Brain Endothelial Cells

(2010) Servio H. Ramirez et al.   AMERICAN JOURNAL OF PATHOLOGY

Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity

(2010) Yun-hyeok Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Anti-amyloidogenic effect of AA3E2 attenuates β-amyloid induced toxicity in SK-N-MC cells

(2010) Hamed Shaykhalishahi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Beyond the Cholinergic Hypothesis: Do Current Drugs Work in Alzheimer's Disease?

(2010) Alessandro Martorana et al.   CNS Neuroscience & Therapeutics

Tanshinone IIA protects the human blood–brain barrier model from leukocyte-associated hypoxia-reoxygenation injury

(2010) Wen-jian Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TEMPOL protects human neuroblastoma SH-SY5Y cells against ß-amyloid-induced cell toxicity

(2010) Pennapa Chonpathompikunlert et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effects of 1,3-diaryl-2-propen-1-one derivatives against H2O2-induced damage in SK-N-MC cells

(2010) Samaneh Bayati et al.   JOURNAL OF APPLIED TOXICOLOGY

Responses of Endothelial Cells from Different Vessels to Inflammatory Cytokines and Shear Stress: Evidence for the Pliability of Endothelial Phenotype

(2010) N. Thin Luu et al.   JOURNAL OF VASCULAR RESEARCH

Neural mechanisms of ageing and cognitive decline

(2010) Nicholas A. Bishop et al.   NATURE

Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease

(2010) Gen He et al.   NATURE

A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease

(2010) Reza M. Salek et al.   NEUROCHEMISTRY INTERNATIONAL

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site

(2010) Kengo Uemura et al.   Nature Communications

Monocytes deliver bioactive nerve growth factor through a brain capillary endothelial cell-monolayer in vitro and counteract degeneration of cholinergic neurons

(2009) Danny Böttger et al.   BRAIN RESEARCH

Searching for new animal models of Alzheimer′s disease

(2009) Roberta Epis et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effect of selaginellin on glutamate-induced cytotoxicity and apoptosis in differentiated PC12 cells

(2009) Chen-Jing Wang et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Comparison of Alzheimer A (1-40) and A (1-42) amyloid fibrils reveals similar protofilament structures

(2009) M. Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA