Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

Memantine Treatment in Patients with Mild to Moderate Alzheimer's Disease: Results of a Randomised, Double-Blind, Placebo-Controlled 6-Month Study

(2017) S. Bakchine et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid Imaging in Aging and Dementia: Testing the Amyloid HypothesisIn Vivo

(2014) G. D. Rabinovici et al.   BEHAVIOURAL NEUROLOGY

Donepezil or memantine improved cognitive functioning in moderate-to-severe Alzheimer disease

(2013) David Burke   ANNALS OF INTERNAL MEDICINE

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pretreatment with Memantine Prevents Alzheimer-Like Alterations Induced by Intrahippocampal Okadaic Acid Administration in Rats

(2012) Eduardo Rigon Zimmer et al.   Current Alzheimer Research

Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer’s Disease

(2012) Elena Simoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cerebrospinal fluid β-amyloid1–42 correlates with rate of progression in Alzheimer’s disease

(2012) George S. Vlachos et al.   JOURNAL OF NEURAL TRANSMISSION

Glutamate system, amyloid β peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology

(2012) Timothy Revett et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease

(2012) Robert Howard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Memantine and cholinesterase inhibitor combination therapy for Alzheimer's disease: a systematic review

(2012) Lucy E Farrimond et al.   BMJ Open

Amyloid β peptide oligomers directly activate NMDA receptors

(2011) Laura Texidó et al.   CELL CALCIUM

Soluble A  Oligomers Inhibit Long-Term Potentiation through a Mechanism Involving Excessive Activation of Extrasynaptic NR2B-Containing NMDA Receptors

(2011) S. Li et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

(2011) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden

(2010) Gil D. Rabinovici et al.   BRAIN

Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease

(2010) C. R. Jack et al.   BRAIN

Inhibition of calpain prevents NMDA-induced cell death and β-amyloid-induced synaptic dysfunction in hippocampal slice cultures

(2010) V Nimmrich et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-  Production

(2010) K. Bordji et al.   JOURNAL OF NEUROSCIENCE

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

CSF biomarkers predict a more malignant outcome in Alzheimer disease

(2010) A. K. Wallin et al.   NEUROLOGY

Senescent synapses and hippocampal circuit dynamics

(2010) Sara N. Burke et al.   TRENDS IN NEUROSCIENCES

Comparative pharmacology and computational modelling yield insights into allosteric modulation of human α7 nicotinic acetylcholine receptors

(2009) David B. Sattelle et al.   BIOCHEMICAL PHARMACOLOGY

Nicotinic Receptors, Amyloid-β, and Synaptic Failure in Alzheimer’s Disease

(2009) Sofia Jürgensen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Novel Nicotinic Acetylcholine Receptor Subtype in Basal Forebrain Cholinergic Neurons with High Sensitivity to Amyloid Peptides

(2009) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Enrichment of MCI and early Alzheimer’s disease treatment trials using neurochemical & imaging candidate biomarkers

(2009) H. Hampel et al.   Journal of Nutrition Health & Aging

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine

(2009) Igor Klyubin et al.   NEUROBIOLOGY OF AGING

CSF biomarkers in relationship to cognitive profiles in Alzheimer disease

(2009) A. E. van der Vlies et al.   NEUROLOGY

Alzheimer’s Disease Amyloid β-Protein and Synaptic Function

(2009) Tomas Ondrejcak et al.   NEUROMOLECULAR MEDICINE

The effects of aging on N-methyl-d-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory

(2009) X. Zhao et al.   NEUROSCIENCE

Long-term Course and Effectiveness of Combination Therapy in Alzheimer Disease

(2008) Alireza Atri et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Effects of memantine and galantamine given separately or in association, on memory and hippocampal neuronal loss after transient global cerebral ischemia in gerbils

(2008) Silvia Lorrio et al.   BRAIN RESEARCH

Memantine Treatment in Patients with Mild to Moderate Alzheimers Disease Already Receiving a Cholinesterase Inhibitor: A Randomized, Double-Blind, Placebo-Controlled Trial

(2008) Anton Porsteinsson et al.   Current Alzheimer Research

Memantine protects rat cortical cultured neurons against β-amyloid-induced toxicity by attenuating tau phosphorylation

(2008) M. S. Song et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amyloid β-protein fragments 25-35 and 31-35 potentiate long-term depression in hippocampal CA1 region of rats in vivo

(2008) Li Cheng et al.   SYNAPSE

Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease

(2007) Alireza Kashani et al.   NEUROBIOLOGY OF AGING