Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient

(2016) Han-Kyu Lee et al.   Stem Cell Research

New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies

(2015) Ebbe Poulsen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Internalized Tau Oligomers Cause Neurodegeneration by Inducing Accumulation of Pathogenic Tau in Human Neurons Derived from Induced Pluripotent Stem Cells

(2015) M. Usenovic et al.   JOURNAL OF NEUROSCIENCE

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A  Pharmacodynamic Responses in Mice, Dogs, and Humans

(2015) P. C. May et al.   JOURNAL OF NEUROSCIENCE

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

(2013) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sox1 marks an activated neural stem/progenitor cell in the hippocampus

(2012) M. Venere et al.   DEVELOPMENT

Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures

(2011) Bin-Kuan Chou et al.   CELL RESEARCH

Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro

(2011) Sandra Gómez-López et al.   GLIA

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains

(2009) Stéphanie Baulac et al.   Molecular Neurodegeneration

The Level of the Transcription Factor Pax6 Is Essential for Controlling the Balance between Neural Stem Cell Self-Renewal and Neurogenesis

(2009) Stephen N. Sansom et al.   PLoS Genetics

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Invited Article: The Alzheimer disease-frontotemporal lobar degeneration spectrum

(2008) J. van der Zee et al.   NEUROLOGY

Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein

(2008) Ting Yang et al.   Molecular Brain