Oncogenic Metabolism Acts as a Prerequisite Step for Induction of Cancer Metastasis and Cancer Stem Cell Phenotype

Aldolase A overexpression is associated with poor prognosis and promotes tumor progression by the epithelial-mesenchymal transition in colon cancer

(2018) Feng Ye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer Energy Metabolism: Shutting Power off Cancer Factory

(2018) Soo-Youl Kim   Biomolecules & Therapeutics

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

(2018) Eunae Sandra Cho et al.   Biomolecules & Therapeutics

Paracrine roles of cellular senescence in promoting tumourigenesis

(2018) Jose Mario Gonzalez-Meljem et al.   BRITISH JOURNAL OF CANCER

ADAM9 mediates the interleukin-6-induced Epithelial–Mesenchymal transition and metastasis through ROS production in hepatoma cells

(2018) Yinying Dong et al.   CANCER LETTERS

Deciphering p53 signaling in tumor suppression

(2018) Stephano S Mello et al.   CURRENT OPINION IN CELL BIOLOGY

CHD4-mediated loss of E-cadherin determines metastatic ability in triple-negative breast cancer cells

(2018) Chi-Wen Luo et al.   EXPERIMENTAL CELL RESEARCH

Emerging Roles of p53 Family Members in Glucose Metabolism

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TP53INP1 inhibits hypoxia-induced vasculogenic mimicry formation via the ROS/snail signalling axis in breast cancer

(2018) Yi Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Upregulation of lactate-inducible snail protein suppresses oncogene-mediated senescence through p16INK4a inactivation

(2018) Xiangrui Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metabolic features of cancer stem cells: the emerging role of lipid metabolism

(2018) Rita Mancini et al.   ONCOGENE

Hypoxia induced EMT: A review on the mechanism of tumor progression and metastasis in OSCC

(2018) Joel P. Joseph et al.   ORAL ONCOLOGY

Biogenesis and function of extracellular vesicles in cancer

(2018) Maarten P. Bebelman et al.   PHARMACOLOGY & THERAPEUTICS

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

(2018) Dongya Jia et al.   Cells

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer

(2017) Marco Sciacovelli et al.   FEBS Journal

Essential Roles of E3 Ubiquitin Ligases in p53 Regulation

(2017) Sanam Sane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy

(2017) Xuetian Yue et al.   JOURNAL OF MOLECULAR BIOLOGY

LincRNa-p21: function and mechanism in cancer

(2017) Shaoyun Chen et al.   MEDICAL ONCOLOGY

Factors involved in cancer metastasis: a better understanding to “seed and soil” hypothesis

(2017) Qiang Liu et al.   Molecular Cancer

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

(2017) Qiuran Xu et al.   Molecular Cancer

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

(2017) Su Yeon Lee et al.   Molecular Cancer

Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?

(2017) Mohit Kumar Jolly et al.   Molecular Oncology

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling

(2017) D J Junk et al.   ONCOGENE

MCU-dependent mitochondrial Ca2+ inhibits NAD+/SIRT3/SOD2 pathway to promote ROS production and metastasis of HCC cells

(2017) T Ren et al.   ONCOGENE

Census and evaluation of p53 target genes

(2017) M Fischer   ONCOGENE

Role for extracellular vesicles in the tumour microenvironment

(2017) Ana O'Loghlen   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?

(2017) Stuart K. Calderwood   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression

(2017) Li Yang et al.   SEMINARS IN CANCER BIOLOGY

Exosomes: Key mediators of metastasis and pre-metastatic niche formation

(2017) Richard J. Lobb et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mitochondrial Metabolism: Yin and Yang for Tumor Progression

(2017) Lorea Valcarcel-Jimenez et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

p53-R273H upregulates neuropilin-2 to promote cell mobility and tumor metastasis

(2017) Tao Lv et al.   Cell Death & Disease

Loss of the novel mitochondrial protein FAM210B promotes metastasis via PDK4-dependent metabolic reprogramming

(2017) Shujuan Sun et al.   Cell Death & Disease

Senescent tumor cells lead the collective invasion in thyroid cancer

(2017) Young Hwa Kim et al.   Nature Communications

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

(2017) Nam Hee Kim et al.   Nature Communications

Mitochondrial metabolites: undercover signalling molecules

(2017) Christian Frezza   Interface Focus

Snail1-expressing cancer-associated fibroblasts induce lung cancer cell epithelial-mesenchymal transition through miR-33b

(2017) Jia You et al.   Oncotarget

Exosomal tetraspanins mediate cancer metastasis by altering host microenvironment

(2017) Jun Lu et al.   Oncotarget

p53 switches off pluripotency on differentiation

(2017) Tongxiang Lin et al.   Stem Cell Research & Therapy

Overexpression of hypoxia-inducible factor and metabolic pathways: possible targets of cancer

(2017) Davinder Singh et al.   Cell and Bioscience

Snail suppresses cellular senescence and promotes fibroblast-led cancer cell invasion

(2017) Satoshi Furuya et al.   FEBS Open Bio

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

The Epithelial-to-Mesenchymal Transition in Breast Cancer: Focus on Basal-Like Carcinomas

(2017) Monica Fedele et al.   Cancers

PKM2 promotes cell migration and inhibits autophagy by mediating PI3K/AKT activation and contributes to the malignant development of gastric cancer

(2017) Chao Wang et al.   Scientific Reports

LDH-A promotes malignant progression via activation of epithelial-to-mesenchymal transition and conferring stemness in muscle-invasive bladder cancer

(2016) Fujin Jiang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

KI67 and DLX2 predict increased risk of metastasis formation in prostate cancer–a targeted molecular approach

(2016) William JF Green et al.   BRITISH JOURNAL OF CANCER

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase

(2016) Xiaozhen He et al.   CANCER RESEARCH

Multiple facets of p53 in senescence induction and maintenance

(2016) Yoshikazu Johmura et al.   CANCER SCIENCE

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism

(2016) Chia-Lin Chen et al.   Cell Metabolism

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

(2016) Christopher D. Wiley et al.   Cell Metabolism

Impact of the physical microenvironment on tumor progression and metastasis

(2016) Fabian Spill et al.   CURRENT OPINION IN BIOTECHNOLOGY

Epithelial–mesenchymal transition (EMT) and metastasis: yes, no, maybe?

(2016) Maren Diepenbruck et al.   CURRENT OPINION IN CELL BIOLOGY

Current Understanding of HSP90 as a Novel Therapeutic Target: An Emerging Approach for the Treatment of Cancer

(2016) Absarul Haque et al.   CURRENT PHARMACEUTICAL DESIGN

Overexpression of DLX2 is associated with poor prognosis and sorafenib resistance in hepatocellular carcinoma

(2016) Jinxia Liu et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Role of mitochondrial dysfunction in cancer progression

(2016) Chia-Chi Hsu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

HSP90 inhibits apoptosis and promotes growth by regulating HIF-1α abundance in hepatocellular carcinoma

(2016) XIN LIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Emerging Non-Canonical Functions and Regulation by p53: p53 and Stemness

(2016) David Olivos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer

(2016) Zhi-Dong Lv et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA Control of p53

(2016) Juan Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors

(2016) Gao Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuropilin-2 promotes melanoma growth and progression in vivo

(2016) Whei F. Moriarty et al.   MELANOMA RESEARCH

Gas1 Inhibits Metastatic and Metabolic Phenotypes in Colorectal Carcinoma

(2016) Q. Li et al.   MOLECULAR CANCER RESEARCH

The Role of PGC1  in Cancer Metabolism and its Therapeutic Implications

(2016) Z. Tan et al.   MOLECULAR CANCER THERAPEUTICS

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

(2016) Bowen Du et al.   MOLECULES

Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

(2016) Marco Sciacovelli et al.   NATURE

SIRT4 inhibits malignancy progression of NSCLCs, through mitochondrial dynamics mediated by the ERK-Drp1 pathway

(2016) L Fu et al.   ONCOGENE

Bypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and Radiotherapy

(2016) Alex Lyakhovich et al.   Oxidative Medicine and Cellular Longevity

Concise Review: Stem Cells and Epithelial-Mesenchymal Transition in Cancer: Biological Implications and Therapeutic Targets

(2016) Ryo Sato et al.   STEM CELLS

SDHB deficiency promotes TGFβ-mediated invasion and metastasis of colorectal cancer through transcriptional repression complex SNAIL1-SMAD3/4

(2016) Haiyu Wang et al.   Translational Oncology

miR-125b inhibited epithelialal–mesenchymal transition of triple-negative breast cancer by targeting MAP2K7

(2016) Zhaojun Chen et al.   OncoTargets and Therapy

Estradiol, TGF-β1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration

(2016) SEONG-JOON PARK et al.   Oncology Letters

Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival

(2016) Edoardo Gaude et al.   Nature Communications

Changing perspective on oncometabolites: from metabolic signature of cancer to tumorigenic and immunosuppressive agents

(2016) Mauro Corrado et al.   Oncotarget

A FASN-TGF-β1-FASN regulatory loop contributes to high EMT/metastatic potential of cisplatin-resistant non-small cell lung cancer

(2016) Li Yang et al.   Oncotarget

Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch

(2016) Su Yeon Lee et al.   Oncotarget

Suppression of endogenous lipogenesis induces reversion of the malignant phenotype and normalized differentiation in breast cancer

(2016) Anatilde M. Gonzalez-Guerrico et al.   Oncotarget

Metabolic enzymes: key modulators of functionality in cancer stem-like cells

(2016) Bo-Wen Dong et al.   Oncotarget

Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer

(2016) Jun Hyoung Park et al.   Cell Reports

Genetic Modifiers of the p53 Pathway

(2016) Subhasree Basu et al.   Cold Spring Harbor Perspectives in Medicine

Genome Stability Requires p53

(2016) Christine M. Eischen   Cold Spring Harbor Perspectives in Medicine

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

(2016) Marie-Julie Nokin et al.   eLife

DNA Damage Response and Immune Defense: Links and Mechanisms

(2016) Rania Nakad et al.   Frontiers in Genetics

Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma

(2016) Adrian Biddle et al.   EBioMedicine

Role of EMT in Metastasis and Therapy Resistance

(2016) Bethany Smith et al.   Journal of Clinical Medicine

Cancer Stem Cell Plasticity Drives Therapeutic Resistance

(2016) Mary Doherty et al.   Cancers

Smad2/3-Regulated Expression of DLX2 Is Associated with Radiation-Induced Epithelial-Mesenchymal Transition and Radioresistance of A549 and MDA-MB-231 Human Cancer Cell Lines

(2016) Yeo-Jin Choi et al.   PLoS One

Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer

(2016) Hugh Colvin et al.   Scientific Reports

DNA repair and aging: the impact of the p53 family

(2015) Sara Nicolai et al.   Aging-US

Roles of Signaling Pathways in the Epithelial-Mesenchymal Transition in Cancer

(2015) Xia Liu et al.   Asian Pacific Journal of Cancer Prevention

Mitochondrial quality control pathways as determinants of metabolic health

(2015) Ntsiki M. Held et al.   BIOESSAYS

Neuropilin-2 induced by transforming growth factor-β augments migration of hepatocellular carcinoma cells

(2015) Philipp Wittmann et al.   BMC CANCER

Epithelial–mesenchymal transition induces similar metabolic alterations in two independent breast cancer cell lines

(2015) Yuvabharath Kondaveeti et al.   CANCER LETTERS

Tumor suppressor p53 and its mutants in cancer metabolism

(2015) Juan Liu et al.   CANCER LETTERS

Metabolic reprogramming supports the invasive phenotype in malignant melanoma

(2015) Ingrid J. Bettum et al.   CANCER LETTERS

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

Tumors and Mitochondrial Respiration: A Neglected Connection

(2015) Andrea Viale et al.   CANCER RESEARCH

Rb-mediated apoptosis or proliferation: It's up to JNK

(2015) Bertrand Mollereau et al.   CELL CYCLE

Essential Role for Oxidative Phosphorylation in Cancer Progression

(2015) Maria Chiara Maiuri et al.   Cell Metabolism

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

(2015) A. H. Chourasia et al.   EMBO REPORTS

Metabolic reprogramming of the tumour microenvironment

(2015) Yazhi Xing et al.   FEBS Journal

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Dlx-2 is implicated in TGF-β- and Wnt-induced epithelial-mesenchymal, glycolytic switch, and mitochondrial repression by Snail activation

(2015) SU YEON LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis

(2015) Yan Xiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Senescent Human Fibroblasts Show Increased Glycolysis and Redox Homeostasis with Extracellular Metabolomes That Overlap with Those of Irreparable DNA Damage, Aging, and Disease

(2015) Emma L. James et al.   JOURNAL OF PROTEOME RESEARCH

p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses

(2015) Sabine Hünten et al.   MOLECULAR & CELLULAR PROTEOMICS

Metabolic pathways promoting cancer cell survival and growth

(2015) Lindsey K. Boroughs et al.   NATURE CELL BIOLOGY

The DNA damage response and immune signaling alliance: Is it good or bad? Nature decides when and where

(2015) Ioannis S. Pateras et al.   PHARMACOLOGY & THERAPEUTICS

Stemness of the hybrid Epithelial/Mesenchymal State in Breast Cancer and Its Association with Poor Survival

(2015) Anne Grosse-Wilde et al.   PLoS One

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells

(2015) Stefano Bartesaghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms

(2015) Monica Cojoc et al.   SEMINARS IN CANCER BIOLOGY

The p53 family and the hypoxia-inducible factors (HIFs): determinants of cancer progression

(2015) Ivano Amelio et al.   TRENDS IN BIOCHEMICAL SCIENCES

Epithelial–Mesenchymal Plasticity: A Central Regulator of Cancer Progression

(2015) Xin Ye et al.   TRENDS IN CELL BIOLOGY

Links between cancer stem cells and epithelial– mesenchymal transition

(2015) Yaling Tang et al.   OncoTargets and Therapy

Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53

(2015) E K Park et al.   Cell Death & Disease

Cancer stem cell targeted therapy: progress amid controversies

(2015) Tao Wang et al.   Oncotarget

Cancer stem cells and signaling pathways in radioresistance

(2015) Lei Chang et al.   Oncotarget

Cancer stem cell related markers of radioresistance in head and neck squamous cell carcinoma

(2015) Ina Kurth et al.   Oncotarget

Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells

(2015) Ronghua Wang et al.   Oncotarget

Deciphering the molecular basis of invasiveness in Sdhb-deficient cells

(2015) Céline Loriot et al.   Oncotarget

Targeting senescent cells enhances adipogenesis and metabolic function in old age

(2015) Ming Xu et al.   eLife

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Cancer stem cell plasticity and tumor hierarchy

(2015) Marina Carla Cabrera   World Journal of Stem Cells

HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer

(2015) Wenjing Zhang et al.   PLoS One

Pyruvate Carboxylase Is Up-Regulated in Breast Cancer and Essential to Support Growth and Invasion of MDA-MB-231 Cells

(2015) Phatchariya Phannasil et al.   PLoS One

B7H1 Expression and Epithelial-To-Mesenchymal Transition Phenotypes on Colorectal Cancer Stem-Like Cells

(2015) Yidan Zhi et al.   PLoS One

Pyruvate kinase M2 regulates glucose metabolism by functioning as a coactivator for hypoxia-inducible factor 1 in cancer cells

(2015) Weibo Luo et al.   Oncotarget

Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory Complex-I activity via Bcl-2 family proteins

(2015) Eun Mi Kim et al.   Oncotarget

Tumor Microenvironmental Signaling Elicits Epithelial-Mesenchymal Plasticity through Cooperation with Transforming Genetic Events

(2015) Damian J. Junk et al.   NEOPLASIA

Activation of NADPH oxidase subunit NCF4 induces ROS-mediated EMT signaling in HeLa cells

(2014) Young Mee Kim et al.   CELLULAR SIGNALLING

Metabolic Profiling Reveals PAFAH1B3 as a Critical Driver of Breast Cancer Pathogenicity

(2014) Melinda M. Mulvihill et al.   CHEMISTRY & BIOLOGY

The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation

(2014) Alfredo Csibi et al.   CURRENT BIOLOGY

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

Wnt meets Warburg: another piece in the puzzle?

(2014) C. B. Thompson   EMBO JOURNAL

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion

(2014) J. Kim et al.   EMBO REPORTS

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

(2014) Daniel T. Shaughnessy et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Restoring the tumour suppressive function of p53 as a parallel strategy in melanoma therapy

(2014) Min Lu et al.   FEBS LETTERS

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

(2014) Matjaz Rokavec et al.   JOURNAL OF CLINICAL INVESTIGATION

WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?

(2014) Victoria Sherwood   MOLECULAR AND CELLULAR BIOLOGY

Heat shock protein 90 promotes epithelial to mesenchymal transition, invasion, and migration in colorectal cancer

(2014) Ganji Purnachandra Nagaraju et al.   MOLECULAR CARCINOGENESIS

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Oncogenic roles of EMT-inducing transcription factors

(2014) Alain Puisieux et al.   NATURE CELL BIOLOGY

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leptin Promotes Metastasis by Inducing an Epithelial-Mesenchymal Transition in A549 Lung Cancer Cells

(2014) Helin Feng et al.   ONCOLOGY RESEARCH

Heat shock proteins in fibrosis and wound healing: Good or evil?

(2014) Pierre-Simon Bellaye et al.   PHARMACOLOGY & THERAPEUTICS

Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition

(2014) A. Hamabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The dichotomy of p53 regulation by noncoding RNAs

(2014) Q. Deng et al.   Journal of Molecular Cell Biology

Contribution of p53 to Metastasis

(2014) E. Powell et al.   Cancer Discovery

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

TSH Signaling Overcomes B-RafV600E–Induced Senescence in Papillary Thyroid Carcinogenesis through Regulation of DUSP6

(2014) Young Hwa Kim et al.   NEOPLASIA

Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives

(2014) Amparo Cano et al.   Cancer Management and Research

EMT or EMT-Promoting Transcription Factors, Where to Focus the Light?

(2014) Stéphane Ansieau et al.   Frontiers in Oncology

FAK and Nanog Cross Talk with p53 in Cancer Stem Cells

(2013) Vita M. Golubovskaya   Anti-Cancer Agents in Medicinal Chemistry

Mitochondria and Metabolic Homeostasis

(2013) Zhiyong Cheng et al.   ANTIOXIDANTS & REDOX SIGNALING

CD24+ ovary cancer cells exhibit an invasive mesenchymal phenotype

(2013) Kyu Sub Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

(2013) Lin Zhang et al.   BMC CANCER

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress

(2013) Francisca Vazquez et al.   CANCER CELL

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

p53-dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene

(2013) Shang-Jui Wang et al.   CELL CYCLE

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway

(2013) P-P Liu et al.   CELL DEATH AND DIFFERENTIATION

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Roles of miRNA in the Initiation and Development of Colorectal Carcinoma

(2013) Yiming Ma et al.   CURRENT PHARMACEUTICAL DESIGN

SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial-mesenchymal transition

(2013) Stefanie Hahn et al.   EMBO JOURNAL

Acquisition of epithelial–mesenchymal transition phenotype and cancer stem cell-like properties in cisplatin-resistant lung cancer cells through AKT/β-catenin/Snail signaling pathway

(2013) Hao Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation

(2013) Guillaume Wettstein et al.   FASEB JOURNAL

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

A critical role for the long non-coding RNA GAS5 in proliferation and apoptosis in non-small-cell lung cancer

(2013) Xuefei Shi et al.   MOLECULAR CARCINOGENESIS

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation

(2013) Jinlong Shi et al.   NEUROLOGICAL SCIENCES

LncRNA loc285194 is a p53-regulated tumor suppressor

(2013) Qian Liu et al.   NUCLEIC ACIDS RESEARCH

Effects of airborne pollutants on mitochondrial DNA Methylation

(2013) Hyang-Min Byun et al.   Particle and Fibre Toxicology

Critical Roles of p53 in Epithelial-Mesenchymal Transition and Metastasis of Hepatocellular Carcinoma Cells

(2013) Zheng Wang et al.   PLoS One

Increased expression of DLX2 correlates with advanced stage of gastric adenocarcinoma

(2013) Peng Tang   WORLD JOURNAL OF GASTROENTEROLOGY

A Tale of Metabolites: The Cross-Talk between Chromatin and Energy Metabolism

(2013) Barbara Martinez-Pastor et al.   Cancer Discovery

Oncogenic Isocitrate Dehydrogenase Mutations: Mechanisms, Models, and Clinical Opportunities

(2013) R. A. Cairns et al.   Cancer Discovery

Epithelial-mesenchymal transition and its regulators are major targets of triple-negative breast cancer

(2013) Ala-Eddin Al Moustafa   Cell Adhesion & Migration

Role of mitochondria in steroidogenesis

(2012) Vassilios Papadopoulos et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Wnt/Snail Signaling Regulates Cytochrome c Oxidase and Glucose Metabolism

(2012) S. Y. Lee et al.   CANCER RESEARCH

Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells

(2012) M. Tamada et al.   CANCER RESEARCH

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

(2012) T. Fiaschi et al.   CANCER RESEARCH

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

STAT3 can serve as a hit in the process of malignant transformation of primary cells

(2012) M Demaria et al.   CELL DEATH AND DIFFERENTIATION

EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness

(2012) Ester Sánchez-Tilló et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

The NF-κB member p65 controls glutamine metabolism through miR-23a

(2012) Moeez G. Rathore et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial dysfunction and cancer metastasis

(2012) Emily I. Chen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Isocitrate Dehydrogenase (IDH) Mutations Promote a Reversible ZEB1/MicroRNA (miR)-200-dependent Epithelial-Mesenchymal Transition (EMT)

(2012) Alexandra R. Grassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer

(2012) Michael W. Hance et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression

(2012) Dallas R. Donohoe et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Epithelial to Mesenchymal Transition Is Activated in Metastatic Pheochromocytomas and Paragangliomas Caused bySDHBGene Mutations

(2012) Céline Loriot et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-κB/HIF-1α pathway

(2012) Guoqing Li et al.   MOLECULAR IMMUNOLOGY

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

(2012) A. Cassago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Emerging roles of PKM2 in cell metabolism and cancer progression

(2012) Weibo Luo et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy

(2012) Chin-Chih Lin et al.   Scientific Reports

Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth

(2011) G. Civenni et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

RB1 and p53 at the crossroad of EMT and triple-negative breast cancer

(2011) Zhe Jiang et al.   CELL CYCLE

Transcription factor Dlx2 protects from TGFβ-induced cell-cycle arrest and apoptosis

(2011) Mahmut Yilmaz et al.   EMBO JOURNAL

Evidence of oncogene-induced senescence in thyroid carcinogenesis

(2011) Maria Grazia Vizioli et al.   ENDOCRINE-RELATED CANCER

HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells

(2011) Giuseppina Comito et al.   FREE RADICAL BIOLOGY AND MEDICINE

Senescence in intraductal papillary mucinous neoplasm of the pancreas

(2011) Yoshihiro Miyasaka et al.   HUMAN PATHOLOGY

Environmental chemical exposures and human epigenetics

(2011) Lifang Hou et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Functional Cooperation between Snail1 and Twist in the Regulation ofZEB1Expression during Epithelial to Mesenchymal Transition

(2011) Natàlia Dave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E-Cadherin/β-Catenin Complex and the Epithelial Barrier

(2011) Xinrui Tian et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

(2011) Nam Hee Kim et al.   JOURNAL OF CELL BIOLOGY

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

(2011) M Fernanda Amary et al.   JOURNAL OF PATHOLOGY

Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis

(2011) Su Lee et al.   Molecular Cancer

Temporal and Spatial Cooperation of Snail1 and Twist1 during Epithelial-Mesenchymal Transition Predicts for Human Breast Cancer Recurrence

(2011) D. D. Tran et al.   MOLECULAR CANCER RESEARCH

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Metabolism unhinged: IDH mutations in cancer

(2011) John R Prensner et al.   NATURE MEDICINE

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

(2011) Hong Wu et al.   NATURE MEDICINE

Identification of additional IDH mutations associated with oncometabolite R(−)-2-hydroxyglutarate production

(2011) P S Ward et al.   ONCOGENE

Reduced Expression of Fumarate Hydratase in Clear Cell Renal Cancer Mediates HIF-2α Accumulation and Promotes Migration and Invasion

(2011) Sunil Sudarshan et al.   PLoS One

Epithelial to Mesenchymal Transition by TGFβ-1 Induction Increases Stemness Characteristics in Primary Non Small Cell Lung Cancer Cell Line

(2011) Giuseppe Pirozzi et al.   PLoS One

Targeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells

(2011) Dara Nalls et al.   PLoS One

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

The Redox Basis of Epigenetic Modifications: From Mechanisms to Functional Consequences

(2010) Anthony R. Cyr et al.   ANTIOXIDANTS & REDOX SIGNALING

Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231

(2010) Monica Morini et al.   BMC CANCER

Cellular senescence predicts treatment outcome in metastasised colorectal cancer

(2010) A M Haugstetter et al.   BRITISH JOURNAL OF CANCER

A novel role for mitochondria in regulating epigenetic modifications in the nucleus

(2010) Dominic Smiraglia et al.   CANCER BIOLOGY & THERAPY

Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence

(2010) Maurice Reimann et al.   CANCER CELL

Ink4a/Arf and Oncogene-Induced Senescence Prevent Tumor Progression during Alternative Colorectal Tumorigenesis

(2010) Moritz Bennecke et al.   CANCER CELL

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Oncogene-induced senescence: the bright and dark side of the response

(2010) Vassilis G Gorgoulis et al.   CURRENT OPINION IN CELL BIOLOGY

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

(2010) Stefan Gross et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

p53 activates the PANK1/ miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins

(2010) Levin Böhlig et al.   NUCLEIC ACIDS RESEARCH

Methylglyoxal Alters the Function and Stability of Critical Components of the Protein Quality Control

(2010) Carla Figueira Bento et al.   PLoS One

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 Research: The Past Thirty Years and the Next Thirty Years

(2010) D. Lane et al.   Cold Spring Harbor Perspectives in Biology

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Homeobox genes in vertebrate forebrain development and disease

(2009) JT Wigle et al.   CLINICAL GENETICS

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

SIK1 Couples LKB1 to p53-Dependent Anoikis and Suppresses Metastasis

(2009) H. Cheng et al.   Science Signaling

Anoikis resistance and tumor metastasis

(2008) Craig D. Simpson et al.   CANCER LETTERS

Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors

(2008) S. Zhang et al.   CANCER RESEARCH

Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression

(2008) Samuel Godar et al.   CELL

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor metabolism: cancer cells give and take lactate

(2008) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Prostate cancer stem cells

(2008) SH Lang et al.   JOURNAL OF PATHOLOGY

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

(2008) Ssang-Taek Lim et al.   MOLECULAR CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY

New roles for pyruvate kinase M2: working out the Warburg effect

(2008) Emily C. Ferguson et al.   TRENDS IN BIOCHEMICAL SCIENCES

Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters

(2007) Sandip Basu et al.   CANCER