Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling

Cancer Stem Cell Plasticity Drives Therapeutic Resistance

(2016) Mary Doherty et al.   Cancers

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance

(2015) V. Adorno-Cruz et al.   CANCER RESEARCH

Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and Interpretations

(2015) K. Rycaj et al.   CANCER RESEARCH

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer

(2015) Michael D. Brooks et al.   Cell Stem Cell

Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

(2015) Heike M. Hermanns   CYTOKINE & GROWTH FACTOR REVIEWS

Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells

(2015) Devon A. Lawson et al.   NATURE

STAT3 integrates cooperative Ras and TGF-β signals that induce Snail expression

(2015) M Saitoh et al.   ONCOGENE

STAT3 selectively interacts with Smad3 to antagonize TGF-β

(2015) G Wang et al.   ONCOGENE

Suppression of cancer relapse and metastasis by inhibiting cancer stemness

(2015) Youzhi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition

(2015) Aaron Goldman et al.   Nature Communications

Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy

(2015) Bee Luan Khoo et al.   Oncotarget

Tumor Microenvironmental Signaling Elicits Epithelial-Mesenchymal Plasticity through Cooperation with Transforming Genetic Events

(2015) Damian J. Junk et al.   NEOPLASIA

Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis

(2014) Ming-Yi Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells

(2014) Ho-June Lee et al.   CANCER CELL

Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition

(2014) Rik Derynck et al.   CURRENT OPINION IN CELL BIOLOGY

Interleukin-6 (IL-6) Trans Signaling Drives a STAT3-dependent Pathway That Leads to Hyperactive Transforming Growth Factor-β (TGF-β) Signaling Promoting SMAD3 Activation and Fibrosis via Gremlin Protein

(2014) Steven O'Reilly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HGF Induces Epithelial-to-Mesenchymal Transition by Modulating the Mammalian Hippo/MST2 and ISG15 Pathways

(2014) Jennifer Farrell et al.   JOURNAL OF PROTEOME RESEARCH

SMAD7: a timer of tumor progression targeting TGF-β signaling

(2014) Lingyu Luo et al.   TUMOR BIOLOGY

The Epithelial-Mesenchymal Transition Factor SNAIL Paradoxically Enhances Reprogramming

(2014) Juli J. Unternaehrer et al.   Stem Cell Reports

HiJAK’d Signaling; the STAT3 Paradox in Senescence and Cancer Progression

(2014) Damian Junk et al.   Cancers

Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure

(2013) Jochen Pöling et al.   BASIC RESEARCH IN CARDIOLOGY

Monocytes/macrophages support mammary tumor invasivity by co-secreting lineage-specific EGFR ligands and a STAT3 activator

(2013) Philip Vlaicu et al.   BMC CANCER

The relevance of the TGF-β Paradox to EMT-MET programs

(2013) Chevaun D. Morrison et al.   CANCER LETTERS

FOXC2 Expression Links Epithelial-Mesenchymal Transition and Stem Cell Properties in Breast Cancer

(2013) B. G. Hollier et al.   CANCER RESEARCH

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer

(2013) Neil E. Bhola et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-6 and Oncostatin-M Synergize with the PI3K/AKT Pathway to Promote Aggressive Prostate Malignancy in Mouse and Human Tissues

(2013) Daniel A. Smith et al.   MOLECULAR CANCER RESEARCH

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Oncostatin-M promotes phenotypic changes associated with mesenchymal and stem cell-like differentiation in breast cancer

(2013) N R West et al.   ONCOGENE

Constitutive CCND1/CDK2 Activity Substitutes for p53 Loss, or MYC or Oncogenic RAS Expression in the Transformation of Human Mammary Epithelial Cells

(2013) Damian J. Junk et al.   PLoS One

The MEK-ERK Pathway Is Necessary for Serine Phosphorylation of Mitochondrial STAT3 and Ras-Mediated Transformation

(2013) Daniel J. Gough et al.   PLoS One

STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor

(2013) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer

(2012) N. P. A. Devika Gunasinghe et al.   CANCER AND METASTASIS REVIEWS

EMT in carcinoma progression and dissemination: Facts, unanswered questions, and clinical considerations

(2012) Jeremy Bastid   CANCER AND METASTASIS REVIEWS

Oncostatin M suppresses oestrogen receptor-α expression and is associated with poor outcome in human breast cancer

(2012) Nathan R West et al.   ENDOCRINE-RELATED CANCER

Regulation of EMT by TGFβ in cancer

(2012) Carl-Henrik Heldin et al.   FEBS LETTERS

Targeting Stat3 and Smad7 to restore TGF-β cytostatic regulation of tumor cells in vitro and in vivo

(2012) R B Luwor et al.   ONCOGENE

TGF-β stimulates Pyk2 expression as part of an epithelial-mesenchymal transition program required for metastatic outgrowth of breast cancer

(2012) M K Wendt et al.   ONCOGENE

Epithelial-mesenchymal transition and stemness features in circulating tumor cells from breast cancer patients

(2011) Cristina Raimondi et al.   BREAST CANCER RESEARCH AND TREATMENT

Nonreceptor Tyrosine Kinase BMX Maintains Self-Renewal and Tumorigenic Potential of Glioblastoma Stem Cells by Activating STAT3

(2011) Olga A. Guryanova et al.   CANCER CELL

c-MYC Functions as a Molecular Switch to Alter the Response of Human Mammary Epithelial Cells to Oncostatin M

(2011) C. E. Kan et al.   CANCER RESEARCH

Cancer Stem Cells in Squamous Cell Carcinoma Switch between Two Distinct Phenotypes That Are Preferentially Migratory or Proliferative

(2011) A. Biddle et al.   CANCER RESEARCH

The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation

(2011) J T Buijs et al.   ONCOGENE

MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1

(2011) L Sun et al.   ONCOGENE

Essential role of Stat3 in PI3K-induced oncogenic transformation

(2011) Jonathan R. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-  signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

(2011) R. Cipriano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer

(2010) Lin Ye et al.   CANCER SCIENCE

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

H3K27me3 regulates BMP activity in developing spinal cord

(2010) N. Akizu et al.   DEVELOPMENT

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

(2010) Mikala Egeblad et al.   DEVELOPMENTAL CELL

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nodal Signaling Recruits the Histone Demethylase Jmjd3 to Counteract Polycomb-Mediated Repression at Target Genes

(2010) O. Dahle et al.   Science Signaling

Molecular Distinctions between Stasis and Telomere Attrition Senescence Barriers Shown by Long-term Culture of Normal Human Mammary Epithelial Cells

(2009) J. C. Garbe et al.   CANCER RESEARCH

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

Mechanisms of the epithelial–mesenchymal transition by TGF-β

(2009) Michael K Wendt et al.   Future Oncology

Interleukin-6 induces an epithelial–mesenchymal transition phenotype in human breast cancer cells

(2009) N J Sullivan et al.   ONCOGENE

Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features

(2009) C. J. Creighton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer and the tumor microenvironment: a review of an essential relationship

(2008) Flaubert Mbeunkui et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Inhibition of STAT3Tyr705 Phosphorylation by Smad4 Suppresses Transforming Growth Factor  -Mediated Invasion and Metastasis in Pancreatic Cancer Cells

(2008) S. Zhao et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Phospho-control of TGF-β superfamily signaling

(2008) Katharine H Wrighton et al.   CELL RESEARCH

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Intrinsic Resistance of Tumorigenic Breast Cancer Cells to Chemotherapy

(2008) X. Li et al.   JNCI-Journal of the National Cancer Institute

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE

Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55

(2008) H Wang et al.   ONCOGENE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One