Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

(2016) Mingjing He et al.   Cell Division

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes

(2015) Barbara Chiavarina et al.   Oncotarget

Metabolic Profiling Reveals PAFAH1B3 as a Critical Driver of Breast Cancer Pathogenicity

(2014) Melinda M. Mulvihill et al.   CHEMISTRY & BIOLOGY

Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes

(2014) Chris Tikellis et al.   DIABETES

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells

(2014) Samantha E. Hiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measurement of methylglyoxal by stable isotopic dilution analysis LC-MS/MS with corroborative prediction in physiological samples

(2014) Naila Rabbani et al.   Nature Protocols

Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer

(2014) F Hosoda et al.   ONCOGENE

Carnosine Inhibits the Proliferation of Human Gastric Cancer SGC-7901 Cells through Both of the Mitochondrial Respiration and Glycolysis Pathways

(2014) Yao Shen et al.   PLoS One

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

Hyperglycemia as a Risk Factor for Cancer Progression

(2014) Tae Young Ryu et al.   Diabetes & Metabolism Journal

Quantification of glyoxal, methylglyoxal and 3-deoxyglucosone in blood and plasma by ultra performance liquid chromatography tandem mass spectrometry: evaluation of blood specimen

(2013) Jean L.J.M. Scheijen et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

A “Turn-On” Fluorescent Sensor for Methylglyoxal

(2013) Tina Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Repositioning metformin for cancer prevention and treatment

(2013) Brendan J. Quinn et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Dual Effect of Methylglyoxal on the Intracellular Ca2+ Signaling and Neurite Outgrowth in Mouse Sensory Neurons

(2012) Beatrice Mihaela Radu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade

(2012) MIGUEL A. FONSECA-SÁNCHEZ et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth

(2012) Makiko Fujii et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Glyoxalase-I Is a Novel Prognosis Factor Associated with Gastric Cancer Progression

(2012) Wan-Li Cheng et al.   PLoS One

Role of glyoxalase I in the proliferation and apoptosis control of human LNCaP and PC3 prostate cancer cells

(2012) Cinzia Antognelli et al.   PROSTATE

Heat-shock protein 27 (Hsp27) as a target of methylglyoxal in gastrointestinal cancer

(2011) Tomoko Oya-Ito et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Fibrin(ogen) may be an important target for methylglyoxal-derived AGE modification in elastic arteries of humans

(2011) Terje Lund et al.   Diabetes & Vascular Disease Research

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Heat Shock Protein 90 Inhibition Depletes LATS1 and LATS2, Two Regulators of the Mammalian Hippo Tumor Suppressor Pathway

(2010) C. J. Huntoon et al.   CANCER RESEARCH

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Diabetes and Cancer: A consensus report

(2010) E. Giovannucci et al.   DIABETES CARE

GLO1-A novel amplified gene in human cancer

(2010) Thomas Santarius et al.   GENES CHROMOSOMES & CANCER

Gene Pathways Associated With Prognosis and Chemotherapy Sensitivity in Molecular Subtypes of Breast Cancer

(2010) Takayuki Iwamoto et al.   JNCI-Journal of the National Cancer Institute

Methylglyoxal Alters the Function and Stability of Critical Components of the Protein Quality Control

(2010) Carla Figueira Bento et al.   PLoS One

Plasma advanced glycation endproduct, methylglyoxal-derived hydroimidazolone is elevated in young, complication-free patients with Type 1 diabetes

(2009) Yingchun Han et al.   CLINICAL BIOCHEMISTRY

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

(2009) Heng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma α-Oxoaldehyde Levels in Diabetic and Nondiabetic Chronic Kidney Disease Patients

(2008) Keisuke Nakayama et al.   AMERICAN JOURNAL OF NEPHROLOGY

An Oncogenomics-Based In Vivo RNAi Screen Identifies Tumor Suppressors in Liver Cancer

(2008) Lars Zender et al.   CELL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone

(2008) A. Yano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA