Emerging Roles of p53 Family Members in Glucose Metabolism

Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis

(2017) Andreas Prokesch et al.   FASEB JOURNAL

Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

(2017) Kanaga Sabapathy et al.   Nature Reviews Clinical Oncology

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells

(2017) S Ros et al.   ONCOGENE

Dual role of autophagy in hallmarks of cancer

(2017) Shikha Satendra Singh et al.   ONCOGENE

PAK4 regulates G6PD activity by p53 degradation involving colon cancer cell growth

(2017) Xiumei Zhang et al.   Cell Death & Disease

The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy

(2016) Marco Napoli et al.   BRITISH JOURNAL OF CANCER

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept

(2016) Vladimir Uversky   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of the p53 tumor suppressor in metabolism and diabetes

(2016) Che-Pei Kung et al.   JOURNAL OF ENDOCRINOLOGY

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

(2016) Xiaomu Li et al.   Nature Communications

The P72R Polymorphism of p53 Predisposes to Obesity and Metabolic Dysfunction

(2016) Che-Pei Kung et al.   Cell Reports

Structural Evolution and Dynamics of the p53 Proteins

(2016) Giovanni Chillemi et al.   Cold Spring Harbor Perspectives in Medicine

Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

(2016) Shi Yun Yeo et al.   eLife

Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

(2016) Yoko Itahana et al.   Scientific Reports

p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway

(2016) Derek A. Franklin et al.   Scientific Reports

Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73

(2015) Avinashnarayan Venkatanarayan et al.   CELL CYCLE

Delta Np63 alpha – Responsive microRNA Modulate the Expression of Metabolic Enzymes

(2015) Edward Ratovitski   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The microRNA-200 family regulates pancreatic beta cell survival in type 2 diabetes

(2015) Bengt-Frederik Belgardt et al.   NATURE MEDICINE

p63 supports aerobic respiration through hexokinase II

(2015) Guiditta Viticchiè et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD

(2015) Cen Zhang et al.   Oncotarget

Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense

(2015) Angelo D’Alessandro et al.   Oncotarget

The effects of p53 on whole organism longevity are mediated by autophagy

(2014) Nektarios Tavernarakis et al.   Autophagy

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation

(2014) Ge Zhou et al.   MOLECULAR CELL

IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo

(2014) Avinashnarayan Venkatanarayan et al.   NATURE

The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense

(2014) Y Itahana et al.   ONCOGENE

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

(2014) Alexander A Shestov et al.   eLife

The MDM2 inhibitor Nutlin-3 attenuates streptozotocin-induced diabetes mellitus and increases serum level of IL-12p40

(2013) Paola Secchiero et al.   ACTA DIABETOLOGICA

p53 regulates glucose metabolism by miR-34a

(2013) Hwa-Ryeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53-dependent regulation of metabolic function through transcriptional activation of pantothenate kinase-1 gene

(2013) Shang-Jui Wang et al.   CELL CYCLE

p63 regulates glutaminase 2 expression

(2013) Giacobbe Arianna et al.   CELL CYCLE

A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation

(2013) Peng Jiang et al.   CELL CYCLE

Semaphorin3E-Induced Inflammation Contributes to Insulin Resistance in Dietary Obesity

(2013) Ippei Shimizu et al.   Cell Metabolism

Type 2 Diabetes and Congenital Hyperinsulinism Cause DNA Double-Strand Breaks and p53 Activity in β Cells

(2013) Sharona Tornovsky-Babeay et al.   Cell Metabolism

Tumor Protein p63/microRNA Network in Epithelial Cancer Cells

(2013) Edward Ratovitski   CURRENT GENOMICS

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

Another fork in the road—life or death decisions by the tumour suppressor p53

(2013) Luis A Carvajal et al.   EMBO REPORTS

Growth Hormone Is Necessary for the p53-Mediated, Obesity-Induced Insulin Resistance in Male C57BL/6J × CBA Mice

(2013) Fausto Bogazzi et al.   ENDOCRINOLOGY

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Analysis of TAp73-Dependent Signaling via Omics Technologies

(2013) Angelo D’Alessandro et al.   JOURNAL OF PROTEOME RESEARCH

AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and Inhibiting Its Activity

(2013) G. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

(2013) Wenjing Du et al.   NATURE CELL BIOLOGY

Tumour-associated mutant p53 drives the Warburg effect

(2013) Cen Zhang et al.   Nature Communications

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

AMPK Promotes p53 Acetylation via Phosphorylation and Inactivation of SIRT1 in Liver Cancer Cells

(2012) C.-W. Lee et al.   CANCER RESEARCH

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Phospho-ΔNp63α/SREBF1 protein interactions: Bridging cell metabolism and cisplatin chemoresistance

(2012) Yiping Huang et al.   CELL CYCLE

Dietary downregulation of mutant p53 levels via glucose restriction

(2012) Olga Catalina Rodriguez et al.   CELL CYCLE

p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure

(2012) Ippei Shimizu et al.   Cell Metabolism

TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism

(2012) Xiaohua Su et al.   Cell Metabolism

Glucose Tolerance in Mice is Linked to the Dose of the p53 Transactivation Domain

(2012) Debra Franck et al.   ENDOCRINE RESEARCH

TAp73 depletion accelerates aging through metabolic dysregulation

(2012) A. Rufini et al.   GENES & DEVELOPMENT

Mutant p53: one name, many proteins

(2012) W. A. Freed-Pastor et al.   GENES & DEVELOPMENT

Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease

(2012) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

Atg7 Modulates p53 Activity to Regulate Cell Cycle and Survival During Metabolic Stress

(2012) I. H. Lee et al.   SCIENCE

A new role of p53 in regulating lipid metabolism

(2012) Xingwu Wang et al.   Journal of Molecular Cell Biology

Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival

(2012) Susana Ros et al.   Cancer Discovery

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

(2011) R. Boidot et al.   CANCER RESEARCH

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

p53 represses autophagy in a cell cycle-dependent fashion

(2011) Ezgi Tasdemir et al.   CELL CYCLE

Mutant p53 protein localized in the cytoplasm inhibits autophagy

(2011) Eugenia Morselli et al.   CELL CYCLE

Mitochondrial targeting signals: Another barcode in p14ARF?

(2011) Koji Itahana et al.   CELL CYCLE

Amino terminal hydrophobic import signals target the p14ARF tumor suppressor to the mitochondria

(2011) Mal Irvine et al.   CELL CYCLE

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

(2011) W Gao et al.   CELL DEATH AND DIFFERENTIATION

 40 Isoform of p53 Controls  -Cell Proliferation and Glucose Homeostasis in Mice

(2011) C. Hinault et al.   DIABETES

Survival of pancreatic beta cells is partly controlled by a TCF7L2-p53-p53INP1-dependent pathway

(2011) Yuedan Zhou et al.   HUMAN MOLECULAR GENETICS

Inactivation ofarf-bp1Induces p53 Activation and Diabetic Phenotypes in Mice

(2011) Ning Kon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1α, a Key Modulator of p53, Promotes Cell Survival upon Metabolic Stress

(2011) Nirmalya Sen et al.   MOLECULAR CELL

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

The p53 family: guardians of maternal reproduction

(2011) Arnold J. Levine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mieap, a p53-Inducible Protein, Controls Mitochondrial Quality by Repairing or Eliminating Unhealthy Mitochondria

(2011) Noriaki Kitamura et al.   PLoS One

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ARF in the mitochondria: The last frontier?

(2010) Koji Itahana et al.   CELL CYCLE

Stimulation of autophagy by the p53 target gene Sestrin2

(2010) Maria Chiara Maiuri et al.   CELL CYCLE

Metformin: Taking away the candy for cancer?

(2010) Mathilde Jalving et al.   EUROPEAN JOURNAL OF CANCER

Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

(2010) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

The role of mutant p53 in human cancer

(2010) Amanda M Goh et al.   JOURNAL OF PATHOLOGY

Requirement of the ATM/p53 Tumor Suppressor Pathway for Glucose Homeostasis

(2010) H. L. Armata et al.   MOLECULAR AND CELLULAR BIOLOGY

Pantothenate Kinase 1 Is Required to Support the Metabolic Transition from the Fed to the Fasted State

(2010) Roberta Leonardi et al.   PLoS One

NADPH Oxidase 2-Derived Reactive Oxygen Species Mediate FFAs-Induced Dysfunction and Apoptosis of β-Cells via JNK, p38 MAPK and p53 Pathways

(2010) Huiping Yuan et al.   PLoS One

p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation

(2010) R. Scherz-Shouval et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Excision of nucleoside analogs in mitochondria by p53 protein

(2009) Mary Bakhanashvili et al.   AIDS

mTOR regulates autophagy-associated genes downstream of p73

(2009) Jennifer M. Rosenbluth et al.   Autophagy

An insight into the mechanistic role of p53-mediated autophagy induction in response to proteasomal inhibition-induced neurotoxicity

(2009) Yunlan Du et al.   Autophagy

Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death

(2009) Kyung-Jin Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis

(2009) Maria A. Lebedeva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

PUMA- and Bax-induced autophagy contributes to apoptosis

(2009) K S Yee et al.   CELL DEATH AND DIFFERENTIATION

p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content

(2009) Joon-Young Park et al.   CIRCULATION RESEARCH

Absence of p53-Dependent Apoptosis Combined With Nonhomologous End-Joining Deficiency Leads to a Severe Diabetic Phenotype in Mice

(2009) O. Tavana et al.   DIABETES

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

(2009) X. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERK and JNK mediate TNFα-induced p53 activation in apoptotic and autophagic L929 cell death

(2008) Yan Cheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activated p53 induces NF-κB DNA binding but suppresses its transcriptional activation

(2008) Keiko Kawauchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondrial p32 Is a Critical Mediator of ARF-Induced Apoptosis

(2008) Koji Itahana et al.   CANCER CELL

p53-Dependent and p53-Independent Activation of Autophagy by ARF

(2008) W. M. Abida et al.   CANCER RESEARCH

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Alterations in MicroRNA Expression Contribute to Fatty Acid-Induced Pancreatic  -Cell Dysfunction

(2008) P. Lovis et al.   DIABETES

ARF Induces Autophagy by Virtue of Interaction with Bcl-xl

(2008) Julia Pimkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)

(2008) Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DAPK-1 Binding to a Linear Peptide Motif in MAP1B Stimulates Autophagy and Membrane Blebbing

(2008) Ben Harrison et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53

(2008) T. S. Wong et al.   NUCLEIC ACIDS RESEARCH