Essential Roles of E3 Ubiquitin Ligases in p53 Regulation

Heat Shock Protein 70s as Potential Molecular Targets for Colon Cancer Therapeutics

(2016) Jennifer D. Black et al.   CURRENT MEDICINAL CHEMISTRY

The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry

(2016) Alina Simerzin et al.   HEPATOLOGY

E3 ubiquitin ligase Cbl-b activates the p53 pathway by targeting Siva1, a negative regulator of ARF, in FLT3 inhibitor-resistant acute myeloid leukemia

(2016) I-K Park et al.   LEUKEMIA

The Ubiquitin Ligase COP1 Promotes Glioma Cell Proliferation by Preferentially Downregulating Tumor Suppressor p53

(2016) Shenshan Zou et al.   MOLECULAR NEUROBIOLOGY

DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway

(2016) Alejandro Parrales et al.   NATURE CELL BIOLOGY

miR-100 antagonism triggers apoptosis by inhibiting ubiquitination-mediated p53 degradation

(2016) G Yang et al.   ONCOGENE

High expression of constitutive photomorphogenic 1 (COP1) is associated with poor prognosis in bladder cancer

(2016) Jianlong Li et al.   TUMOR BIOLOGY

Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress

(2016) Nan Xie et al.   Scientific Reports

Clinical Overview of MDM2/X-Targeted Therapies

(2016) Andrew Burgess et al.   Frontiers in Oncology

Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy

(2015) Sanam Sane et al.   CELL STRESS & CHAPERONES

A genetic variant of MDM4 influences regulation by multiple microRNAs in prostate cancer

(2015) S. Stegeman et al.   ENDOCRINE-RELATED CANCER

MDM4 regulation by the let-7 miRNA family in the DNA damage response of glioma cells

(2015) Chen Xie et al.   FEBS LETTERS

Structure of human MDM2 complexed with RPL11 reveals the molecular basis of p53 activation

(2015) Jiangge Zheng et al.   GENES & DEVELOPMENT

Functional Significance of Point Mutations in Stress Chaperone Mortalin and Their Relevance to Parkinson Disease

(2015) Renu Wadhwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Protein Interaction between Nucleotide Binding Domain of Hsp70 and p53 Motif

(2015) Asita Elengoe et al.   International Journal of Genomics

Regulation of Mutant p53 Protein Expression

(2015) Reshma Vijayakumaran et al.   Frontiers in Oncology

COP1 and GSK3β Cooperate to Promote c-Jun Degradation and Inhibit Breast Cancer Cell Tumorigenesis

(2015) Jing Shao et al.   NEOPLASIA

The regulation of MDM2 oncogene and its impact on human cancers

(2014) Y. Zhao et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network

(2014) Y. Hoffman et al.   Journal of Molecular Cell Biology

Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cells

(2014) S Sane et al.   Cell Death & Disease

p28, A first in class peptide inhibitor of cop1 binding to p53

(2013) T Yamada et al.   BRITISH JOURNAL OF CANCER

miR-661 downregulates both Mdm2 and Mdm4 to activate p53

(2013) Y Hoffman et al.   CELL DEATH AND DIFFERENTIATION

The Role of miR-18b in MDM2-p53 Pathway Signaling and Melanoma Progression

(2013) Altaf A Dar et al.   JNCI-Journal of the National Cancer Institute

Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase

(2013) Xingwu Wang et al.   Nature Communications

p53 N-terminal phosphorylation: a defining layer of complex regulation

(2012) L. M. M. Jenkins et al.   CARCINOGENESIS

Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy

(2012) Q. Li et al.   CLINICAL CANCER RESEARCH

High Level of COP1 Expression is Associated with Poor Prognosis in Primary Gastric Cancer

(2012) Yuan-fang Li et al.   International Journal of Biological Sciences

Functional analysis and consequences of Mdm2 E3 ligase inhibition in human tumor cells

(2012) M Wade et al.   ONCOGENE

BMK1 is involved in the regulation of p53 through disrupting the PML–MDM2 interaction

(2012) Q Yang et al.   ONCOGENE

MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading Frame

(2012) Pooja Mandke et al.   PLoS One

TRIM29 negatively regulates p53 via inhibition of Tip60

(2011) Takuya Sho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Recent Advances in the Therapeutic Perspectives of Nutlin-3

(2011) Paola Secchiero et al.   CURRENT PHARMACEUTICAL DESIGN

miR-605joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress

(2011) Jiening Xiao et al.   EMBO JOURNAL

Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2

(2011) Hae Mi Joo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

miR-10a overexpression is associated with NPM1 mutations and MDM4 downregulation in intermediate-risk acute myeloid leukemia

(2011) Dmitriy Ovcharenko et al.   EXPERIMENTAL HEMATOLOGY

p53 regulation by ubiquitin

(2011) Christopher L. Brooks et al.   FEBS LETTERS

MdmX Protein Is Essential for Mdm2 Protein-mediated p53 Polyubiquitination

(2011) Xinjiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice

(2011) Domenico Migliorini et al.   JOURNAL OF CLINICAL INVESTIGATION

Gambogic Acid, a Natural Product Inhibitor of Hsp90

(2011) Jason Davenport et al.   JOURNAL OF NATURAL PRODUCTS

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

(2011) Hong Wu et al.   NATURE MEDICINE

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11

(2011) Masato Sasaki et al.   NATURE MEDICINE

Role of Pirh2 in Mediating the Regulation of p53 and c-Myc

(2011) Anne Hakem et al.   PLoS Genetics

Making sense of ubiquitin ligases that regulate p53

(2010) Abhinav K. Jain et al.   CANCER BIOLOGY & THERAPY

Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

(2010) Flavia Pichiorri et al.   CANCER CELL

Preclinical pharmacokinetics, metabolism, and toxicity of azurin-p28 (NSC745104) a peptide inhibitor of p53 ubiquitination

(2010) Lee Jia et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Definition of Ubiquitination Modulator COP1 as a Novel Therapeutic Target in Human Hepatocellular Carcinoma

(2010) Y.-H. Lee et al.   CANCER RESEARCH

14-3-3  Exerts Tumor-Suppressor Activity Mediated by Regulation of COP1 Stability

(2010) C.-H. Su et al.   CANCER RESEARCH

An Illegitimate microRNA Target Site within the 3' UTR of MDM4 Affects Ovarian Cancer Progression and Chemosensitivity

(2010) J. Wynendaele et al.   CANCER RESEARCH

Promotion of CHIP-Mediated p53 Degradation Protects the Heart From Ischemic Injury

(2010) Atsuhiko T. Naito et al.   CIRCULATION RESEARCH

CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates

(2010) Marta Stankiewicz et al.   FEBS Journal

CHIP-dependent p53 regulation occurs specifically during cellular senescence

(2010) Christina Sisoula et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP

(2010) Jia Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Interplay between MDM2, MDMX, Pirh2 and COP1: the negative regulators of p53

(2010) Lan Wang et al.   MOLECULAR BIOLOGY REPORTS

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

The C terminus of p53 binds the N-terminal domain of MDM2

(2010) Masha V Poyurovsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The p53 orchestra: Mdm2 and Mdmx set the tone

(2010) Mark Wade et al.   TRENDS IN CELL BIOLOGY

The Tumor Suppressor p53: From Structures to Drug Discovery

(2010) A. C. Joerger et al.   Cold Spring Harbor Perspectives in Biology

p53-based Cancer Therapy

(2010) D. P. Lane et al.   Cold Spring Harbor Perspectives in Biology

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

Suppression of the mouse double minute 4 gene causes changes in cell cycle control in a human mesothelial cell line responsive to ultraviolet radiation exposure

(2009) Melisa Bunderson-Schelvan et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Stress-dependent Daxx-CHIP Interaction Suppresses the p53 Apoptotic Program

(2009) Holly McDonough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53

(2009) Tom Van Maerken et al.   JNCI-Journal of the National Cancer Institute

Axin determines cell fate by controlling the p53 activation threshold after DNA damage

(2009) Qinxi Li et al.   NATURE CELL BIOLOGY

Limited Role of Murine ATM in Oncogene-Induced Senescence and p53-Dependent Tumor Suppression

(2009) Alejo Efeyan et al.   PLoS One

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53

(2009) D. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine double minute 2: p53-independent roads lead to genome instability or death

(2009) Alyssa Bouska et al.   TRENDS IN BIOCHEMICAL SCIENCES

The MDM2 Inhibitor Nutlins as an Innovative Therapeutic Tool for the Treatment of Haematological Malignancies

(2008) Paola Secchiero et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular basis of Pirh2-mediated p53 ubiquitylation

(2008) Yi Sheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chaperone-dependent stabilization and degradation of p53 mutants

(2008) P Muller et al.   ONCOGENE

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

(2008) S. Shangary et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE