Oncogenic roles of EMT-inducing transcription factors

Twist Modulates Breast Cancer Stem Cells by Transcriptional Regulation of CD24 Expression

(2015) Farhad Vesuna et al.   NEOPLASIA

Blocking of p53-Snail Binding, Promoted by Oncogenic K-Ras, Recovers p53 Expression and function

(2015) Sun-Hye Lee et al.   NEOPLASIA

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Switch in the Expression of Embryonic EMT-Inducers Drives the Development of Malignant Melanoma

(2013) Julie Caramel et al.   CANCER CELL

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

(2013) Wai Leong Tam et al.   CANCER CELL

Loss of FBP1 by Snail-Mediated Repression Provides Metabolic Advantages in Basal-like Breast Cancer

(2013) Chenfang Dong et al.   CANCER CELL

Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial-Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis

(2013) T. Yokobori et al.   CANCER RESEARCH

p53-Induced miR-15a/16-1 and AP4 Form a Double-Negative Feedback Loop to Regulate Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer

(2013) Lei Shi et al.   CANCER RESEARCH

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

(2013) Christine L. Chaffer et al.   CELL

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Slug Expression during Melanoma Progression

(2012) Stephanie H. Shirley et al.   AMERICAN JOURNAL OF PATHOLOGY

Plasticity of disseminating cancer cells in patients with epithelial malignancies

(2012) Natalia Bednarz-Knoll et al.   CANCER AND METASTASIS REVIEWS

A “Twist box” Code of p53 Inactivation: Twist box:p53 Interaction Promotes p53 Degradation

(2012) Sara Piccinin et al.   CANCER CELL

Metastatic Colonization Requires the Repression of the Epithelial-Mesenchymal Transition Inducer Prrx1

(2012) Oscar H. Ocaña et al.   CANCER CELL

Spatiotemporal Regulation of Epithelial-Mesenchymal Transition Is Essential for Squamous Cell Carcinoma Metastasis

(2012) Jeff H. Tsai et al.   CANCER CELL

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

TWIST1 a New Determinant of Epithelial to Mesenchymal Transition in EGFR Mutated Lung Adenocarcinoma

(2012) Karine Pallier et al.   PLoS One

Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis

(2012) Phuoc T. Tran et al.   PLoS Genetics

EMT Inducers Catalyze Malignant Transformation of Mammary Epithelial Cells and Drive Tumorigenesis towards Claudin-Low Tumors in Transgenic Mice

(2012) Anne-Pierre Morel et al.   PLoS Genetics

The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization

(2011) S. Goossens et al.   BLOOD

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

(2011) Florian A. Karreth et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

The tumorigenicity of diploid and aneuploid human pluripotent stem cells

(2011) Barak Blum et al.   CELL CYCLE

RB1 and p53 at the crossroad of EMT and triple-negative breast cancer

(2011) Zhe Jiang et al.   CELL CYCLE

Genetic Predisposition Directs Breast Cancer Phenotype by Dictating Progenitor Cell Fate

(2011) Theresa A. Proia et al.   Cell Stem Cell

Nuclear Snail1 and nuclear ZEB1 protein expression in invasive and intraductal human breast carcinomas

(2011) Joseph Geradts et al.   HUMAN PATHOLOGY

Epithelial to mesenchymal transition in early stage endometrioid endometrial carcinoma

(2011) Nuria Montserrat et al.   HUMAN PATHOLOGY

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?

(2011) Christina Scheel et al.   INTERNATIONAL JOURNAL OF CANCER

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization

(2011) Manav Korpal et al.   NATURE MEDICINE

Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized

(2010) Elsa Quintana et al.   CANCER CELL

Epidermal Growth Factor Receptor and Mutant p53 Expand an Esophageal Cellular Subpopulation Capable of Epithelial-to-Mesenchymal Transition through ZEB Transcription Factors

(2010) S. Ohashi et al.   CANCER RESEARCH

Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells

(2010) I Kogan-Sakin et al.   CELL DEATH AND DIFFERENTIATION

SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells

(2010) Zhenzhi Chng et al.   Cell Stem Cell

A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity

(2010) Sergio Ruiz et al.   CURRENT BIOLOGY

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma

(2010) María Ángeles Castilla et al.   JOURNAL OF PATHOLOGY

ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events

(2010) Sejeong Shin et al.   MOLECULAR CELL

Deconstructing the molecular portraits of breast cancer

(2010) Aleix Prat et al.   Molecular Oncology

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

TWISTing an embryonic transcription factor into an oncoprotein

(2010) S Ansieau et al.   ONCOGENE

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures

(2010) H. Mizuno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial-Mesenchymal Transition

(2009) Michael W. Klymkowsky et al.   AMERICAN JOURNAL OF PATHOLOGY

Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics

(2009) B. T. Hennessy et al.   CANCER RESEARCH

Immune-Induced Epithelial to Mesenchymal Transition In vivo Generates Breast Cancer Stem Cells

(2009) M. Santisteban et al.   CANCER RESEARCH

The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

(2009) Angelo Cicalese et al.   CELL

Downregulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells

(2009) Yohei Shimono et al.   CELL

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs

(2009) R. Grant Rowe et al.   JOURNAL OF CELL BIOLOGY

Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition

(2009) Erica L. McCoy et al.   JOURNAL OF CLINICAL INVESTIGATION

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling

(2009) Douglas S. Micalizzi et al.   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

A Twist-Snail Axis Critical for TrkB-Induced Epithelial-Mesenchymal Transition-Like Transformation, Anoikis Resistance, and Metastasis

(2009) M. A. Smit et al.   MOLECULAR AND CELLULAR BIOLOGY

Small but effective moves towards a greener China

(2009) Wanxin Li   NATURE

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

(2009) Ulrich Wellner et al.   NATURE CELL BIOLOGY

p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug

(2009) Shu-Ping Wang et al.   NATURE CELL BIOLOGY

TWIST Family of Basic Helix-Loop-Helix Transcription Factors Mediate Human Mesenchymal Stem Cell Growth and Commitment

(2009) Sandra Isenmann et al.   STEM CELLS

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence

(2008) Stéphane Ansieau et al.   CANCER CELL

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

(2008) S. Spaderna et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

(2008) D. Sarrio et al.   CANCER RESEARCH

A Double-Negative Feedback Loop between ZEB1-SIP1 and the microRNA-200 Family Regulates Epithelial-Mesenchymal Transition

(2008) C. P. Bracken et al.   CANCER RESEARCH

Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

(2008) A. J. Trimboli et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Zeb1 links epithelial-mesenchymal transition and cellular senescence

(2008) Y. Liu et al.   DEVELOPMENT

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

(2008) Ulrike Burk et al.   EMBO REPORTS

Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing

(2008) Valerie Arnoux et al.   MOLECULAR BIOLOGY OF THE CELL

Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines

(2008) D Olmeda et al.   ONCOGENE

Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition

(2008) Anne-Pierre Morel et al.   PLoS One

Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

(2008) A. Swarbrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CANCER: The Metastasis Cascade

(2008) C. A. Klein   SCIENCE