Journal
JOURNAL OF MOLECULAR CELL BIOLOGY
Volume 6, Issue 3, Pages 198-205Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mju017
Keywords
noncoding RNA; p53; activation; mutation; 3 ' UTR; polymorphism; ribosomopathies
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Funding
- NIH [CA138688, GM103492]
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The p53 tumor suppressor gene is the most frequently mutated gene in cancer. Significant progress has been made to discern the importance of p53 in coordinating cellular responses to DNA damage, oncogene activation, and other stresses. Noncoding RNAs are RNA molecules functioning without being translated into proteins. In this work, we discuss the dichotomy of p53 regulation by noncoding RNAs with four unconventional questions. First, is overexpression of microRNAs responsible for p53 inactivation in the absence of p53 mutation? Second, are there somatic mutations in the noncoding regions of the p53 gene? Third, is there a germline mutant in the noncoding regions of the p53 gene that predisposes carriers to cancer? Fourth, can p53 activation mediated by a noncoding RNA mutation cause cancer? This work highlights the prominence of noncoding RNAs in p53 dysregulation and tumorigenesis.
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