Lymphangioleiomyomatosis — a wolf in sheep’s clothing

Changes in Lung Function and Chylous Effusions in Patients With Lymphangioleiomyomatosis Treated With Sirolimus

(2013) Angelo M. Taveira-DaSilva et al.   ANNALS OF INTERNAL MEDICINE

β-Catenin Is a Useful Adjunct Immunohistochemical Marker for the Diagnosis of Pulmonary Lymphangioleiomyomatosis

(2011) Richard J. Flavin et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Diffuse Cystic Lung Disease at High-Resolution CT

(2011) Danielle M. Seaman et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Prevalence of Uterine and Adnexal Involvement in Pulmonary Lymphangioleiomyomatosis

(2011) Takuo Hayashi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Autophagy

(2011) Jane Yu et al.   Autophagy

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

(2011) Chang Hwa Jung et al.   Autophagy

Transcriptional Control of Cellular Metabolism by mTOR Signaling

(2011) J. L. Yecies et al.   CANCER RESEARCH

Feedback on Fat: p62-mTORC1-Autophagy Connections

(2011) Jorge Moscat et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth, and chemosensitivity under hypoxic conditions

(2011) Elizabeth M. Matthew et al.   CELL CYCLE

Rare Lung Disease Research

(2011) Samir Gupta et al.   CHEST

Sirolimus Therapy for Angiomyolipoma in Tuberous Sclerosis and Sporadic Lymphangioleiomyomatosis: A Phase 2 Trial

(2011) D. M. Davies et al.   CLINICAL CANCER RESEARCH

Radiological evidence of lymphangioleiomyomatosis in female and male patients with tuberous sclerosis complex

(2011) M.E.A.P.M. Adriaensen et al.   CLINICAL RADIOLOGY

Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis

(2011) Nicole A. Neuman et al.   EMBO Molecular Medicine

Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin

(2011) A. J. Malhowski et al.   HUMAN MOLECULAR GENETICS

Doxiciclina em pacientes com linfangioleiomiomatose: segurança e eficácia no bloqueio de metaloproteinases

(2011) Suzana Pinheiro Pimenta et al.   Jornal Brasileiro de Pneumologia

mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells

(2011) E. A. Goncharova et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis

(2011) Francis X. McCormack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiomyolipoma Have Common Mutations in TSC2 but No Other Common Genetic Events

(2011) Wei Qin et al.   PLoS One

Multicenter Phase 2 Trial of Sirolimus for Tuberous Sclerosis: Kidney Angiomyolipomas and Other Tumors Regress and VEGF- D Levels Decrease

(2011) Sandra L. Dabora et al.   PLoS One

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent

(2011) A. Parkhitko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of variability in national and regional data to estimate the prevalence of lymphangioleiomyomatosis

(2011) E.C. Harknett et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Epigallocatechin-3-gallate ameliorates hyperglycemia-induced embryonic vasculopathy and malformation by inhibition of Foxo3a activation

(2010) Peixin Yang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Effects of Prolactin onTSC2-Null Eker Rat Cells and in Pulmonary Lymphangioleiomyomatosis

(2010) Yasuhiro Terasaki et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Screening for Lymphangioleiomyomatosis by High-Resolution Computed Tomography in Young, Nonsmoking Women Presenting with Spontaneous Pneumothorax Is Cost-Effective

(2010) Jared T. Hagaman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance, and cancer therapy

(2010) Andrew Y. Choo et al.   CELL CYCLE

Serum Vascular Endothelial Growth Factor-D Prospectively Distinguishes Lymphangioleiomyomatosis From Other Diseases

(2010) Lisa R. Young et al.   CHEST

Role of autophagy in suppression of inflammation and cancer

(2010) Eileen White et al.   CURRENT OPINION IN CELL BIOLOGY

European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis

(2010) S. R. Johnson et al.   EUROPEAN RESPIRATORY JOURNAL

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

High levels of extracellular matrix metalloproteinase inducer are expressed in lymphangioleiomyomatosis

(2010) Nao Odajima et al.   HUMAN PATHOLOGY

Rheb GTPase Controls Apoptosis by Regulating Interaction of FKBP38 with Bcl-2 and Bcl-XL

(2010) Dongzhu Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development

(2010) Magdalena Karbowniczek et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical Activity of mTOR Inhibition With Sirolimus in Malignant Perivascular Epithelioid Cell Tumors: Targeting the Pathogenic Activation of mTORC1 in Tumors

(2010) Andrew J. Wagner et al.   JOURNAL OF CLINICAL ONCOLOGY

Lymphangioleiomyomatosis: A Disease Involving the Lymphatic System

(2010) Kuniaki Seyama et al.   Lymphatic Research and Biology

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply

(2010) Andrew Y. Choo et al.   MOLECULAR CELL

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tuberous sclerosis complex: linking cancer to metabolism

(2010) Virginie Mieulet et al.   TRENDS IN MOLECULAR MEDICINE

Melanoma-Associated Antigen Expression in Lymphangioleiomyomatosis Renders Tumor Cells Susceptible to Cytotoxic T Cells

(2009) Jared Klarquist et al.   AMERICAN JOURNAL OF PATHOLOGY

The Loss of Tuberin Promotes Cell Invasion through the β-Catenin Pathway

(2009) Elizabeth A. Barnes et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Utility of [ 18 F]2-Fluoro-2-Deoxyglucose-PET in Sporadic and Tuberous Sclerosis-Associated Lymphangioleiomyomatosis

(2009) Lisa R. Young et al.   CHEST

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TSC1 and TSC2 mutations in patients with lymphangioleiomyomatosis and tuberous sclerosis complex

(2009) D A Muzykewicz et al.   JOURNAL OF MEDICAL GENETICS

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

(2009) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells

(2009) Jane J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tuberous Sclerosis Complex Regulates Trafficking of Glucose Transporters and Glucose Uptake

(2008) Xiuyun Jiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Lymphangioleiomyomatosis

(2008) Francis X. McCormack   CHEST

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

(2008) Tiffiney R. Hartman et al.   HUMAN MOLECULAR GENETICS

Activation of the Estrogen Receptor Contributes to the Progression of Pulmonary Lymphangioleiomyomatosis via Matrix Metalloproteinase-Induced Cell Invasiveness

(2008) Marilyn K. Glassberg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cathepsin-k expression in pulmonary lymphangioleiomyomatosis

(2008) Marco Chilosi et al.   MODERN PATHOLOGY

Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

(2008) Umut Ozcan et al.   MOLECULAR CELL

Diagnostic Potential of Serum VEGF-D for Lymphangioleiomyomatosis

(2008) Lisa R. Young et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sirolimus for Angiomyolipoma in Tuberous Sclerosis Complex or Lymphangioleiomyomatosis

(2008) John J. Bissler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Matrix metalloproteinases in blood from patients with LAM

(2008) Nao Odajima et al.   RESPIRATORY MEDICINE