Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction

The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence

(2016) Sebastian Haferkamp et al.   Aging-US

A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging

(2014) David M. Nelson et al.   AGE

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

(2013) Ludovic Deriano et al.   Annual Review of Genetics

Autophagy and senescence

(2013) David A. Gewirtz   Autophagy

Autophagy Plays a Critical Role in the Degradation of Active RHOA, the Control of Cell Cytokinesis, and Genomic Stability

(2013) A. Belaid et al.   CANCER RESEARCH

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

(2013) Praveen Rajendran et al.   Epigenetics

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

(2013) Juan Carlos Acosta et al.   NATURE CELL BIOLOGY

In situ visualization of telomere elongation patterns in human cells

(2013) Morgan E. Diolaiti et al.   NUCLEIC ACIDS RESEARCH

The Role of Autophagy in Genome Stability through Suppression of Abnormal Mitosis under Starvation

(2013) Aiko Matsui et al.   PLoS Genetics

Autophagy acts as a safeguard mechanism against G-quadruplex ligand-mediated DNA damage

(2012) Nicola Ivan Orlotti et al.   Autophagy

Telomerase Reactivation following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases

(2012) Zhihu Ding et al.   CELL

Subversion of Autophagy by Kaposi's Sarcoma-Associated Herpesvirus Impairs Oncogene-Induced Senescence

(2012) Andrew M. Leidal et al.   Cell Host & Microbe

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

Tumor Suppressor and Aging Biomarker p16INK4aInduces Cellular Senescence without the Associated Inflammatory Secretory Phenotype

(2011) Jean-Philippe Coppé et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Telomere dysfunction and chromosome instability

(2011) John P. Murnane   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

HDACs link the DNA damage response, processing of double-strand breaks and autophagy

(2011) Thomas Robert et al.   NATURE

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

On the scent of pleiotropy

(2011) N. D. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Making Cellular Memories

(2010) Devin R. Burrill et al.   CELL

The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

(2010) Rekha Rai et al.   EMBO JOURNAL

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

(2010) Rebecca Lock et al.   MOLECULAR BIOLOGY OF THE CELL

The Terminal Telomeric DNA Sequence Determines the Mechanism of Dysfunctional Telomere Fusion

(2010) Bradley A. Stohr et al.   MOLECULAR CELL

PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation

(2009) Elsa-Noah N'Diaye et al.   EMBO REPORTS

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells

(2009) W.-J. Zhou et al.   MOLECULAR CANCER THERAPEUTICS

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

(2009) Maximina H. Yun et al.   NATURE

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

ATM Mediates Cytotoxicity of a Mutant Telomerase RNA in Human Cancer Cells

(2008) B. A. Stohr et al.   CANCER RESEARCH

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY