Cellular senescence and protein degradation

Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging

(2016) Mikhail V. Blagosklonny   Aging-US

Targeting the nucleolus for cancer intervention

(2014) Jaclyn E. Quin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ERKs in Cancer: Friends or Foes?

(2014) Xavier Deschênes-Simard et al.   CANCER RESEARCH

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

YAP/TEAD-Mediated Transcription Controls Cellular Senescence

(2013) Q. Xie et al.   CANCER RESEARCH

The HSP70 family and cancer

(2013) M. E. Murphy   CARCINOGENESIS

Non-Cell-Autonomous Tumor Suppression by p53

(2013) Amaia Lujambio et al.   CELL

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2

(2013) Astrid Vennemann et al.   CELL CYCLE

Targeting the Y/CCAAT box in cancer: YB-1 (YBX1) or NF-Y?

(2013) D Dolfini et al.   CELL DEATH AND DIFFERENTIATION

MEK drives cyclin D1 hyperelevation during geroconversion

(2013) O V Leontieva et al.   CELL DEATH AND DIFFERENTIATION

Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation

(2013) X. Deschenes-Simard et al.   GENES & DEVELOPMENT

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

(2013) S. Inoue et al.   GENES & DEVELOPMENT

Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

(2013) Melanie Theodore Malloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Localized Stat3 Promotes Breast Cancer Growth via Phosphorylation of Serine 727

(2013) Qifang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysosome-mediated processing of chromatin in senescence

(2013) Andre Ivanov et al.   JOURNAL OF CELL BIOLOGY

The Complexity of Human Ribosome Biogenesis Revealed by Systematic Nucleolar Screening of Pre-rRNA Processing Factors

(2013) Lionel Tafforeau et al.   MOLECULAR CELL

An ORC/Cdc6/MCM2-7 Complex Is Formed in a Multistep Reaction to Serve as a Platform for MCM Double-Hexamer Assembly

(2013) Alejandra Fernández-Cid et al.   MOLECULAR CELL

A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence

(2013) Joanna Kaplon et al.   NATURE

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b

(2013) Timo H-W. Lüdtke et al.   PLoS Genetics

YB-1 protein: functions and regulation

(2013) Dmitry N. Lyabin et al.   Wiley Interdisciplinary Reviews-RNA

The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype

(2012) Geunwon Kim et al.   AGING CELL

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Autophagy-dependent senescence in response to DNA damage and chronic apoptotic stress

(2012) Kamini Singh et al.   Autophagy

Hypoxia, MTOR and autophagy

(2012) Mikhail V. Blagosklonny   Autophagy

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

(2012) Marina Kolesnichenko et al.   CELL CYCLE

Orc2 protects ORCA from ubiquitin-mediated degradation

(2012) Zhen Shen et al.   CELL CYCLE

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis

(2012) Claudia Capparelli et al.   CELL CYCLE

Subversion of Autophagy by Kaposi's Sarcoma-Associated Herpesvirus Impairs Oncogene-Induced Senescence

(2012) Andrew M. Leidal et al.   Cell Host & Microbe

Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

(2012) Anitha Suram et al.   EMBO JOURNAL

Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

(2012) Pier Paolo Scaglioni et al.   EMBO Molecular Medicine

Reduction of STAT3 expression induces mitochondrial dysfunction and autophagy in cardiac HL-1 cells

(2012) Myriam Elschami et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells

(2012) Zhao JunGang et al.   FEBS LETTERS

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

(2012) L. C. W. Vredeveld et al.   GENES & DEVELOPMENT

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

(2012) O. Aksoy et al.   GENES & DEVELOPMENT

Proteolytic Degradation of the Yap1 Transcription Factor Is Regulated by Subcellular Localization and the E3 Ubiquitin Ligase Not4

(2012) Kailash Gulshan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Import of the Transcription Factor STAT3 into Mitochondria Depends on GRIM-19, a Component of the Electron Transport Chain

(2012) Prasad Tammineni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin induces permanent growth arrest of human colon cancer cells: Link between senescence and autophagy

(2012) Grazyna Mosieniak et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch

(2012) Y Ishikawa et al.   ONCOGENE

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

(2012) I Paul et al.   ONCOGENE

Transcriptional Repressor NIR Functions in the Ribosome RNA Processing of Both 40S and 60S Subunits

(2012) Jianguo Wu et al.   PLoS One

Hypoxia suppresses conversion from proliferative arrest to cellular senescence

(2012) O. V. Leontieva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagic activity dictates the cellular response to oncogenic RAS

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-binding protein nucleolin in disease

(2012) Kotb Abdelmohsen et al.   RNA Biology

Role of the promyelocytic leukaemia protein in cell death regulation

(2012) P Salomoni et al.   Cell Death & Disease

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly

(2012) Laure Crabbe et al.   Cell Reports

Tom34: A cytosolic cochaperone of the Hsp90/Hsp70 protein complex involved in mitochondrial protein import

(2011) Pierre Faou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors

(2011) Thomas De Raedt et al.   CANCER CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Rapamycin decelerates cellular senescence

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Signaling at the gate: Phosphorylation of the mitochondrial protein import machinery

(2011) Sanjana Rao et al.   CELL CYCLE

KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin

(2011) Rosemarie Kepkay et al.   CELL CYCLE

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence

(2011) Nadine Martin et al.   EMBO JOURNAL

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis

(2011) H. Wei et al.   GENES & DEVELOPMENT

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Regulation of E2Fs and senescence by PML nuclear bodies

(2011) M. Vernier et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells

(2011) Yoshihiro Inami et al.   JOURNAL OF CELL BIOLOGY

Proteotoxic stress of cancer: Implication of the heat-shock response in oncogenesis

(2011) Chengkai Dai et al.   JOURNAL OF CELLULAR PHYSIOLOGY

YB-1, the E2F Pathway, and Regulation of Tumor Cell Growth

(2011) Annette Lasham et al.   JNCI-Journal of the National Cancer Institute

CHIP E3 ligase regulates mammalian senescence by modulating the levels of oxidized proteins

(2011) Christina Sisoula et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Oxidative Stress-Mediated Regulation of Proteasome Complexes

(2011) Charity T. Aiken et al.   MOLECULAR & CELLULAR PROTEOMICS

Activation of the PIK3CA/AKT Pathway Suppresses Senescence Induced by an Activated RAS Oncogene to Promote Tumorigenesis

(2011) Alyssa L. Kennedy et al.   MOLECULAR CELL

Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival

(2011) Mohamed Elgendy et al.   MOLECULAR CELL

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

(2011) Gina M. DeNicola et al.   NATURE

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

SUMO playing tag with ubiquitin

(2011) Gerrit J.K. Praefcke et al.   TRENDS IN BIOCHEMICAL SCIENCES

Major heat shock protein Hsp72 controls oncogene-induced senescence

(2010) Michael Sherman   Annals of the New York Academy of Sciences

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

(2010) Agustin Chicas et al.   CANCER CELL

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

Involvement of PML nuclear bodies in CBP degradation through the ubiquitin-proteasome pathway

(2010) Jonathan R. St-Germain et al.   Epigenetics

Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells

(2010) S. H. Choi et al.   GENES & DEVELOPMENT

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies

(2010) P. Sharma et al.   JOURNAL OF CELL SCIENCE

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis

(2010) Motoko Sasaki et al.   LABORATORY INVESTIGATION

Genome-wide YFP Fluorescence Complementation Screen Identifies New Regulators for Telomere Signaling in Human Cells

(2010) Ok-Hee Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

DDB2, an Essential Mediator of Premature Senescence

(2010) Nilotpal Roy et al.   MOLECULAR AND CELLULAR BIOLOGY

Mammalian DEAD Box Protein Ddx51 Acts in 3' End Maturation of 28S rRNA by Promoting the Release of U8 snoRNA

(2010) L. Srivastava et al.   MOLECULAR AND CELLULAR BIOLOGY

Replication Termination at Eukaryotic Chromosomes Is Mediated by Top2 and Occurs at Genomic Loci Containing Pausing Elements

(2010) Daniele Fachinetti et al.   MOLECULAR CELL

A WD-Repeat Protein Stabilizes ORC Binding to Chromatin

(2010) Zhen Shen et al.   MOLECULAR CELL

The ARF Tumor Suppressor Controls Ribosome Biogenesis by Regulating the RNA Polymerase I Transcription Factor TTF-I

(2010) Frédéric Lessard et al.   MOLECULAR CELL

MAGE-RING Protein Complexes Comprise a Family of E3 Ubiquitin Ligases

(2010) Jennifer M. Doyle et al.   MOLECULAR CELL

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

The scaffold protein Ste5 directly controls a switch-like mating decision in yeast

(2010) Mohan K. Malleshaiah et al.   NATURE

Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites

(2010) Paula Martinez et al.   NATURE CELL BIOLOGY

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

(2010) Lynn Bedford et al.   NATURE REVIEWS DRUG DISCOVERY

Cotranscriptional exon skipping in the genotoxic stress response

(2010) Martin Dutertre et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

(2010) A. Sfeir et al.   SCIENCE

Induction of heat shock proteins for protection against oxidative stress

(2009) Bernadett Kalmar et al.   ADVANCED DRUG DELIVERY REVIEWS

Essentials for ATP Synthesis by F1F0ATP Synthases

(2009) Christoph von Ballmoos et al.   Annual Review of Biochemistry

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

p53-Dependent Translational Control of Senescence and Transformation via 4E-BPs

(2009) Emmanuel Petroulakis et al.   CANCER CELL

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

DDB1-CUL4 and MLL1 Mediate Oncogene-Induced p16INK4a Activation

(2009) Y. Kotake et al.   CANCER RESEARCH

Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription

(2009) Rodrigo Bermejo et al.   CELL

E6AP promotes the degradation of the PML tumor suppressor

(2009) I Louria-Hayon et al.   CELL DEATH AND DIFFERENTIATION

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Human RAP1 inhibits non-homologous end joining at telomeres

(2009) Jay Sarthy et al.   EMBO JOURNAL

Fibrillarin and Nop56 interact before being co-assembled in box C/D snoRNPs

(2009) Tanguy Lechertier et al.   EXPERIMENTAL CELL RESEARCH

Rplp1 bypasses replicative senescence and contributes to transformation

(2009) A. Artero-Castro et al.   EXPERIMENTAL CELL RESEARCH

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence

(2009) O. Moiseeva et al.   MOLECULAR AND CELLULAR BIOLOGY

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

(2009) P. Hydbring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation

(2009) D. J. Gough et al.   SCIENCE

Function of Mitochondrial Stat3 in Cellular Respiration

(2009) J. Wegrzyn et al.   SCIENCE

Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells

(2008) Susann Patschan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Analysis of ABCG2 expression and side population identifies intrinsic drug efflux in the HCC cell line MHCC-97L and its modulation by Akt signaling

(2008) Chen Hu et al.   CARCINOGENESIS

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Free radicals and senescence

(2008) Teng Lu et al.   EXPERIMENTAL CELL RESEARCH

Identification of nucleolar effects in JNK-deficient cells

(2008) Antoine Mialon et al.   FEBS LETTERS

A topoisomerase II-dependent mechanism for resetting replicons at the S-M-phase transition

(2008) O. Cuvier et al.   GENES & DEVELOPMENT

CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation

(2008) D. M. Burns et al.   GENES & DEVELOPMENT

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

(2008) Min Sung Kim et al.   HUMAN PATHOLOGY

Critical Role of Nucleostemin in Pre-rRNA Processing

(2008) Liudmila Romanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chromatin tethering effects of hNopp140 are involved in the spatial organization of nucleolus and the rRNA gene transcription

(2008) Yi-Tzang Tsai et al.   JOURNAL OF BIOMEDICAL SCIENCE

RBBP6 Interacts with Multifunctional Protein YB-1 through Its RING Finger Domain, Leading to Ubiquitination and Proteosomal Degradation of YB-1

(2008) Moredreck Chibi et al.   JOURNAL OF MOLECULAR BIOLOGY

PML Activates Transcription by Protecting HIPK2 and p300 from SCFFbx3-Mediated Degradation

(2008) Y. Shima et al.   MOLECULAR AND CELLULAR BIOLOGY

Heat Shock Protein Hsp72 Controls Oncogene-Induced Senescence Pathways in Cancer Cells

(2008) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

CSIG Inhibits PTEN Translation in Replicative Senescence

(2008) L. Ma et al.   MOLECULAR AND CELLULAR BIOLOGY

A Novel Role for PA28γ-Proteasome in Nuclear Speckle Organization and SR Protein Trafficking

(2008) Véronique Baldin et al.   MOLECULAR BIOLOGY OF THE CELL

Topoisomerase II Inactivation Prevents the Completion of DNA Replication in Budding Yeast

(2008) Jonathan Baxter et al.   MOLECULAR CELL

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

(2008) D Zhuang et al.   ONCOGENE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY

Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

(2007) Kirsteen H. Maclean et al.   JOURNAL OF CLINICAL INVESTIGATION