Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 5, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2014.00157
Keywords
senescence; oncogene-induced senescence; autophagy; tumor suppression mechanisms; cancer
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Funding
- National Agency for the Scientific and Technologic Promotion (ANPCyT)
- National Council for Scientific and Technical Research (CONICET)
- University of Buenos Aires (UBA-UBACyT)
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The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and evaluate the current trend of this growing research field, which has relevance in future perspectives toward therapeutic options against cancer.
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