Review
Pharmacology & Pharmacy
Urvi M. Parmar, Manjiri P. Jalgaonkar, Yogesh A. Kulkarni, Manisha J. Oza
Summary: The incidence of diabetes is increasing globally, and it is associated with hyperglycemia and disrupted metabolic pathways. Autophagy plays a crucial role in maintaining cellular homeostasis, but disrupted autophagy contributes to metabolic disorders such as obesity and diabetes. Nutrient-sensing pathways, including SIRT1, mTOR, and AMPK, regulate autophagy and they could be potential therapeutic targets for reducing diabetic complications.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, General & Internal
Hongqin Sheng, Duo Zhang, Jiaqi Zhang, Yanmei Zhang, Zhaoyu Lu, Wei Mao, Xusheng Liu, Lei Zhang
Summary: This study found that kaempferol (KPF) has a protective effect on diabetic nephropathy (DN) by regulating the AMPK/mTOR pathway, reducing apoptosis of renal podocytes, and enhancing autophagy.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Shahira M. Ezzat, Heba M. I. Abdallah, Noha N. Yassen, Rasha A. Radwan, Eman S. Mostafa, Maha M. Salama, Mohamed A. Salem
Summary: The study concluded that the phenolic-rich fraction of Physalis peruviana L. fruits has a protective effect against diabetic nephropathy, potentially through enhancing autophagy and suppressing apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei
Summary: This study found that the progression of diabetic nephropathy is influenced by the polyamine metabolic pool, particularly the decrease in spermine content. High glucose can lead to increased kidney weight, abnormal kidney function, increased urinary albumin excretion, mesangial thickening, and loss or fusion of podocytes.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Panai Song, Yinyin Chen, Zhiwen Liu, Hong Liu, Li Xiao, Lin Sun, Jiali Wei, Liyu He
Summary: This study found that the expression of MALAT1, LIN28A and Nox4 was increased in diabetic nephropathy tissues and cells treated with high glucose. Overexpression of these genes led to increased cell apoptosis, oxidative stress, and inflammation, while knockdown of them had the opposite effect. Furthermore, MALAT1 interacted directly with LIN28A and facilitated the interaction between LIN28A and Nox4, stabilizing Nox4 mRNA. Our findings provide potential therapeutic targets for diabetic nephropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Siamak Tabibzadeh
Summary: Autophagy is a crucial process for maintaining cellular metabolic demands and preventing aging, disease, and cancer. Genetic defects in autophagy genes and age-induced decline of autophagy can lead to various abnormalities and loss of cellular control.
Article
Immunology
Lin Yang, Siming Yuan, Rongrong Wang, Xiaoyu Guo, Yongsheng Xie, Wei Wei, Liqin Tang
Summary: This study identified the overlapping targets of berberine (BBR) and diabetic nephropathy (DN) using network pharmacology. It was found that VEGFR2 is the main target of BBR. Molecular docking and CETSA confirmed the high binding affinity between BBR and VEGFR2 protein, leading to interference with the PI3K/AKT/mTOR signaling pathway. In vitro and in vivo experiments showed that BBR could inhibit abnormal proliferation of mesangial cells and improve renal function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ke Chen, Bo Yu, Jie Liao
Summary: This study showed that lncRNA SOX2OT alleviates the pathogenesis of DN by regulating Akt/mTOR-mediated autophagy, suppressing the proliferation and fibrosis of mesangial cells.
MOLECULAR MEDICINE
(2021)
Article
Plant Sciences
Chen Chen, Jiulong Ma, Chun Sheng Miao, Huayu Zhang, Ming Zhang, Xia Cao, Yan Shi
Summary: The study demonstrated that Trigonelline (TRL) could improve proliferation of human mesangial cells (HMC), restore autophagy inhibition induced by high glucose through regulating miR-5189-5p and HIF1AN expression. This suggests that TRL may be a new treatment strategy to protect mesangial cells from damage caused by high glucose.
Article
Endocrinology & Metabolism
Hansen Yang, Jia Wang, Zheng Zhang, Rui Peng, Dan Lv, Handeng Liu, Yan Sun
Summary: In diabetic nephropathy, Rmrp promotes proliferation and fibrosis of mesangial cells by regulating miR-1a-3p and JunD expression levels, with Sp1 playing a key regulatory role in this process.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Seunghyeok Choi, Seon Pyo Hong, Jung Hyun Bae, Sang Heon Suh, Hosung Bae, Kyung Pyo Kang, Hyuek Jong Lee, Gou Young Koh
Summary: This study reveals that high blood glucose in diabetes mellitus activates YAP/TAZ through the canonical Hippo pathway, leading to excessive proliferation of MCs, extracellular matrix deposition, endothelial cell impairment, glomerular sclerosis, albuminuria, and reduced glomerular filtration rate, which are the hallmarks of DN. Mechanistically, YAP/TAZ bind and stabilize N-Myc protein, enhancing its transcriptional activity and eventually causing MC impairments and DN pathogenesis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fanrui Meng, Yukai Cao, Mir Hassan Khoso, Kai Kang, Guiping Ren, Wei Xiao, Deshan Li
Summary: The combined use of FGF21 and Insulin shows a better therapeutic effect on DN compared to using FGF21 or Insulin alone. This combination not only improves various symptoms in DN mice, but also promotes the transformation of M1 type macrophages into M2 type macrophages and regulates the expression of autophagy-related genes.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
Li Chen, Guibin Mei, Chunjie Jiang, Xueer Cheng, Dan Li, Ying Zhao, Huimin Chen, Cheng Wan, Ping Yao, Chao Gao, Yuhan Tang
Summary: The study revealed senescence occurring in DN mice and the reversal effect of CO, which improved autophagy dysfunction through dissociating Beclin-1-Bcl-2 complex. Further results showed that autophagy inhibitors blocked the improvement of CO on senescence, and autophagy regulated the degradation of senescence-related secretory phenotype.
CELL PROLIFERATION
(2021)
Article
Endocrinology & Metabolism
Hong Liu, Quan Wang, Ge Shi, Wenqiang Yang, Yanmin Zhang, Weidong Chen, Sheng Wan, Fei Xiong, Zengsi Wang
Summary: Emodin effectively improves renal tissue damage and reduces proteinuria in diabetic nephropathy rats by regulating the AMPK/mTOR-autophagy signaling pathway, suppressing cell apoptosis and enhancing podocyte autophagy.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Ying-hua He, Guo Tian
Summary: Autophagy plays a crucial role in renal cell carcinoma, with many autophagy-related proteins serving as prognostic markers. Researchers are exploring synthetic and phytochemical drugs targeting autophagy for RCC therapy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Shuang Liang, Guang-Yan Cai, Zhi-Yu Duan, Shu-wen Liu, Jie Wu, Yang Lv, Kai Hou, Zuo-xiang Li, Xue-Guang Zhang, Xiang-Mei Chen
Article
Oncology
Dan Dong, Guang-yan Cai, Yi-chun Ning, Jing-chao Wang, Yang Lv, Quan Hong, Shao-yuan Cui, Bo Fu, Ya-nan Guo, Xiang-mei Chen
Article
Immunology
Yang Lu, Yan Mei, Lei Chen, Lingling Wu, Xu Wang, Yingjie Zhang, Bo Fu, Xizhao Chen, Yuansheng Xie, Guangyan Cai, Xueyuan Bai, Qinggang Li, Xiangmei Chen
CELLULAR & MOLECULAR IMMUNOLOGY
(2019)
Article
Biochemical Research Methods
Chen Shao, Mindi Zhao, Xizhao Chen, Haidan Sun, Yehong Yang, Xiaoping Xiao, Zhengguang Guo, Xiaoyan Liu, Yang Lv, Xiangmei Chen, Wei Sun, Di Wu, Youhe Gao
MOLECULAR & CELLULAR PROTEOMICS
(2019)
Article
Biochemical Research Methods
Pengsheng Chen, Huan Wang, Wenhao Zhang, Yuling Chen, Yang Lv, Di Wu, Mingzhou Guo, Haiteng Deng
MOLECULAR & CELLULAR PROTEOMICS
(2019)
Article
Biochemical Research Methods
Yang Lu, Guangda Luo, Songbiao Zhu, Xu Wang, Yuling Chen, ZhouHuan Dong, Shiyu Wang, Jie Ma, Haiteng Deng, Di Wu, Jun Dong
CLINICAL PROTEOMICS
(2020)
Article
Oncology
Russell K. Pachynski, Eric H. Kim, Natalia Miheecheva, Nikita Kotlov, Akshaya Ramachandran, Ekaterina Postovalova, Ilia Galkin, Viktor Svekolkin, Yang Lyu, Qiong Zou, Dengfeng Cao, Joseph Gaut, Joseph E. Ippolito, Alexander Bagaev, Maria Bruttan, Olga Gancharova, Krystle Nomie, Maria Tsiper, Gerald L. Andriole, Ravshan Ataullakhanov, James J. Hsieh
Summary: The study identified distinct molecular, cellular, and structural characteristics associated with mpMRI-visible csPCa, while mpMRI-invisible tumors were similar to normal prostate tissue. Immune profiles did not significantly differ between mpMRI-visible and mpMRI-invisible prostate cancer in the patient cohort, but a 24-gene stromal signature enriched in mpMRI-invisible prostate cancer was identified. Prostate cancer with strong stromal signature exhibited a favorable survival outcome within the patient cohort.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Kosuke Tanaka, Helena A. Yu, Shaoyuan Yang, Song Han, S. Duygu Selcuklu, Kwanghee Kim, Shriram Ramani, Yogesh Tengarai Ganesan, Allison Moyer, Sonali Sinha, Yuchen Xie, Kota Ishizawa, Hatice U. Osmanbeyoglu, Yang Lyu, Nitin Roper, Udayan Guha, Charles M. Rudin, Mark G. Kris, James J. Hsieh, Emily H. Cheng
Summary: Combination therapy with EGFR and Aurora B inhibitors enhances osimertinib-induced apoptosis, effectively eliminating cancer cells and overcoming resistance, mainly by affecting the stability of BIM and PUMA.
Article
Oncology
Maria Sorokina, Danil Stupichev, Yang Lyu, Akshaya Ramachandran, Natalia Miheecheva, Jessica H. Brown, Krystle Nomie, Ekaterina Postovalova, Alexander Bagaev, Maria Tsiper, James J. Hsieh
Summary: The study demonstrated the ability of RNA-Seq to detect PD-L1 expression in ccRCC clinical samples as accurately as IHC. Furthermore, RNA-Seq analysis identified different immune environments in ccRCC, which correlated with IHC results. These findings suggest the potential clinical utility of PD-L1 detection by RNA-Seq in ccRCC.
CLINICAL GENITOURINARY CANCER
(2021)
Article
Oncology
Dana C. Borcherding, Neha Amin, Kevin He, Xiaochun Zhang, Yang Lyu, Carina Dehner, Himanshi Bhatia, Angad Gothra, Layla Daud, Peter Ruminski, Christine A. Pratilas, Kai Pollard, Taylor Sundby, Brigitte C. Widemann, Angela C. Hirbe
Summary: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas with limited treatment options and poor survival rates. Inhibition of TYK2 has shown promising results in decreasing proliferation and inducing apoptosis in MPNST, making it a potential therapeutic target.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yuchen Xie, Merve Sahin, Toru Wakamatsu, Akane Inoue-Yamauchi, Wanming Zhao, Song Han, Amrita M. Nargund, Shaoyuan Yang, Yang Lyu, James J. Hsieh, Christina S. Leslie, Emily H. Cheng
Summary: SETD2 is the most frequently mutated epigenetic modifier in lung adenocarcinoma, with a mutation frequency of approximately 9%. The loss of SETD2 function promotes tumorigenesis by activating intronic enhancers to drive oncogenic transcriptional output, including the KRAS transcriptional signature and PRC2-repressed targets. Additionally, SETD2 loss sensitizes KRAS-mutant lung cancer to inhibition of histone chaperones, the FACT complex, or transcriptional elongation, suggesting potential therapeutic strategies for SETD2 mutant cancers.
Meeting Abstract
Oncology
Natalia Miheecheva, Akshaya Ramachandran, Yang Lyu, Ekaterina Postovalova, Viktor Svekolkin, Ilia Galkin, Pavel Ovcharov, Diana Shamsutdinova, Vladimir Zyrin, Alexander Bagaev, Krystle Nomie, Felix Frenkel, Ravshan Ataullakhanov, James J. Hsieh
Article
Oncology
Zongze He, Jijun Li, Yan Mei, Yang Lv, Fei Zhu, Ran Liu, Xu Wang, Fenghua Yao, Li Zhang, Xiangmei Chen
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2018)
Article
Pharmacology & Pharmacy
Xiaoyuan Ning, Zhong Yin, Zuoxiang Li, Jiayun Xu, Linna Wang, Wanjun Shen, Yang Lu, Guangyan Cai, Xueguang Zhang, Xiangmei Chen
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2017)
Article
Cell Biology
Zhiyong Huang, Quan Hong, Xueguang Zhang, Wenzhen Xiao, Liyuan Wang, Shaoyuan Cui, Zhe Feng, Yang Lv, Guangyan Cai, Xiangmei Chen, Di Wu
CELL COMMUNICATION AND SIGNALING
(2017)