期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 22, 期 15, 页码 5123-5127出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201600515
关键词
asymmetric synthesis; chromenedione; multicomponent reaction; N-heterocyclic carbene; spiropyrazolone
资金
- Alexander von Humboldt Foundation
A novel one-pot, three-component diastereo- and enantioselective synthesis of spiropyrazolones has been developed involving the aldol condensation of an enal to generate ,-unsaturated pyrazolones, which react with a second equivalent of enal through an N-heterocyclic carbene (NHC)-catalyzed [3+2] annulation. The desired spirocyclopentane pyrazolones are obtained in moderate to good yields and good to excellent stereoselectivities. Alternatively, starting from cyclic 1,3-diketones, 2,5-chromenediones are available through [2+4] annulation.
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