4.5 Article

Enantioselective Synthesis of Spirooxindole α-exo-Methylene-γ-butyrolactones from 3-OBoc-Oxindoles

期刊

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2014, 期 9, 页码 1893-1898

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201301684

关键词

Organocatalysis; Lewis bases; Asymmetric catalysis; Spiro compounds; Allylic alkylation

资金

  1. Department of Science & Technology, Government of India, New Delhi [SR/S1/OC-60/2006]

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Chiral Lewis bases facilitated the synthesis of highly functionalized spirooxindoles containing -exo-methylene--butyrolactones in high yields (76-92%) and excellent enantioselectivities (up to 98% ee) at ambient temperature.

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