期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2015, 期 15, 页码 3320-3326出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500152
关键词
Organocatalysis; Asymmetric catalysis; Domino reactions; Multicomponent reactions; Spiro compounds; Enantioselectivity
资金
- Beijing Municipal Commission of Education [JC015001200902]
- Beijing Municipal Natural Science Foundation [7102010, 2122008]
- Basic Research Foundation of Beijing University of Technology [X4015001201101]
- Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality [PHR201008025]
- Doctoral Scientific Research Start-up Foundation of Beijing University of Technology [52015001200701]
In the presence of cinchona-thiourea organocatalyst C1, the developed organocatalytic three-component cascade reaction of isatins, malononitrile, and 2-hydroxynaphthalene-1,4-diones readily proceeded to furnish chiral pyranonaphthoquinone-fused spirooxindoles in excellent chemical yields and high enantioselectivities (up to 99% yield and 97%ee). The absolute configurations of the spirooxindoles were assigned on the basis of an X-ray single crystal structure. Moreover, a reaction mechanism is proposed that accounts for the stereocontrolled formation of the chiral spirooxindoles,.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据