An NHC-Catalyzed In Situ Activation Strategy to β-Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+2] Annulation for Spirocyclic Oxindolo-γ-butyrolactones

On the Mechanism of N-Heterocyclic Carbene-Catalyzed Reactions Involving Acyl Azoliums

(2014) Jessada Mahatthananchai et al.   ACCOUNTS OF CHEMICAL RESEARCH

N-Heterocyclic Carbene Catalyzed Activation of Esters: A New Option for Asymmetric Domino Reactions

(2014) Pankaj Chauhan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to Oxoquinoline Heterocycles by N-Heterocyclic Carbene Catalyzed Ester Activation for Selective Reaction with an Enone

(2014) Zhenqian Fu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Highly Substituted β-Lactones through Oxidative Carbene Catalysis with LiCl as Cooperative Lewis Acid

(2014) Srikrishna Bera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

β-Functionalization of Carboxylic Anhydrides with β-Alkyl Substituents through Carbene Organocatalysis

(2014) Zhichao Jin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Formal [3+2] Annulation Reaction of Enals: An Efficient Enantioselective Access to Spiro-Heterocycles

(2014) Chang Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Cyclocondensation of α,β-Unsaturated Carboxylic Acids: Enantioselective Synthesis of Pyrrolidinone and Dihydropyridinone Derivatives

(2014) Xiang-Yu Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stereoselective synthesis of ε-lactones or spiro-heterocycles through NHC-catalyzed annulation: divergent reactivity by catalyst control

(2014) Min Wang et al.   CHEMICAL COMMUNICATIONS

Metal-Free Multicomponent Syntheses of Pyridines

(2014) Christophe Allais et al.   CHEMICAL REVIEWS

Organocatalytic Lewis base functionalisation of carboxylic acids, esters and anhydrides via C1-ammonium or azolium enolates

(2014) Louis C. Morrill et al.   CHEMICAL SOCIETY REVIEWS

Stereoselective Total Synthesis and Structural Elucidation of (−)-Indoxamycins A-F

(2014) Chi He et al.   CHEMISTRY-A EUROPEAN JOURNAL

Microwave-Assisted Tandem Organocatalytic Peptide-Coupling Intramolecular aza-Michael Reaction: α,β-UnsaturatedN-Acyl Pyrazoles as Michael Acceptors

(2014) María Sánchez-Roselló et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Development in the Asymmetric Michael Addition for Carbon-Carbon Bond Formation

(2014) Majid Heravi et al.   CURRENT ORGANIC CHEMISTRY

N-Heterocyclic Carbene Catalysis as a Tool for Gaining Access to the 3,4-Dihydropyran-2-one Skeleton

(2014) Domenico C. M. Albanese et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Isothiourea-Catalyzed Asymmetric Synthesis of β-Lactams and β-Amino Esters from Arylacetic Acid Derivatives and N-Sulfonylaldimines

(2014) Siobhan R. Smith et al.   JOURNAL OF ORGANIC CHEMISTRY

Direct β-Alkylation of Aldehydes via Photoredox Organocatalysis

(2014) Jack A. Terrett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Annulations for Dihydroquinolones by in Situ Generation of Azolium Enolates

(2014) Anna Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis

(2014) Mikail E. Abbasov et al.   NATURAL PRODUCT REPORTS

Ligand-enabled cross-coupling of C(sp3)–H bonds with arylboron reagents via Pd(II)/Pd(0) catalysis

(2014) Kelvin S. L. Chan et al.   Nature Chemistry

Catalytic, enantioselective vinylogous Michael reactions

(2014) Christoph Schneider et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Di-, Tri-, and Tetrasubstituted Pyridines from (Phenylthio)carboxylic Acids and 2-[Aryl(tosylimino)methyl]acrylates

(2014) Daniel G. Stark et al.   ORGANIC LETTERS

N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirocyclic Oxindole–Dihydropyranones

(2014) Zhaoxin Xiao et al.   ORGANIC LETTERS

Synthesis of Bicyclic Guanidines via Cascade Hydroamination/Michael Additions of Mono-N-acryloylpropargylguanidines

(2014) Ki-Hyeok Kwon et al.   ORGANIC LETTERS

Substrate-Controlled Michael Additions of Chiral Ketones to Enones

(2014) Mireia Fàbregas et al.   ORGANIC LETTERS

Facile Synthesis of γ-Ketophosphonates by an Intermolecular Stetter Reaction onto Vinylphosphonates

(2014) Atanu Patra et al.   ORGANIC LETTERS

Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)H Bonds

(2013) Qi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed [4+3] Annulation of Enals ando-Quinone Methides: Highly Enantioselective Synthesis of Benzo-ε-Lactones

(2013) Hui Lv et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isothiourea-Mediated One-Pot Synthesis of Functionalized Pyridines

(2013) Daniel G. Stark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-Catalyzed Hydroacylation of Styrenes

(2013) Michael Schedler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Branched Domino Reaction: Asymmetric Organocatalytic Two-Component Four-Step Synthesis of Polyfunctionalized Cyclohexene Derivatives

(2013) Xiaofei Zeng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule

(2013) Michael S. Poslusney et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

sp2 C–H bond activation in water and catalytic cross-coupling reactions

(2013) Bin Li et al.   CHEMICAL SOCIETY REVIEWS

Scope and Limitations of Auxiliary-Assisted, Palladium-Catalyzed Arylation and Alkylation of sp2 and sp3 C–H Bonds

(2013) Enrico T. Nadres et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium(0)-Catalyzed Alkynylation of C(sp3)–H Bonds

(2013) Jian He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis

(2013) Zhenqian Fu et al.   Nature Chemistry

An internal affair

(2013) Jeffrey W. Bode   Nature Chemistry

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

Iodination of Remote Ortho-C–H Bonds of Arenes via Directed SEAr: A Streamlined Synthesis of Tetrahydroquinolines

(2013) William A. Nack et al.   ORGANIC LETTERS

Direct Arylation of Primary and Secondary sp3 C–H Bonds with Diarylhyperiodonium Salts via Pd Catalysis

(2013) Fei Pan et al.   ORGANIC LETTERS

Photoredox Activation for the Direct  -Arylation of Ketones and Aldehydes

(2013) M. T. Pirnot et al.   SCIENCE

Applications of Acceptorless Dehydrogenation and Related Transformations in Chemical Synthesis

(2013) C. Gunanathan et al.   SCIENCE

cis-Enals in N-heterocyclic carbene-catalyzed reactions: distinct stereoselectivity and reactivity

(2013) Xingkuan Chen et al.   Chemical Science

Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study

(2013) Louis C. Morrill et al.   Chemical Science

Alkane Metathesis by Tandem Alkane-Dehydrogenation–Olefin-Metathesis Catalysis and Related Chemistry

(2012) Michael C. Haibach et al.   ACCOUNTS OF CHEMICAL RESEARCH

Exploiting Acyl and Enol Azolium Intermediates via N-Hetero- cyclic Carbene-Catalyzed Reactions of α-Reducible Aldehydes

(2012) Harit U. Vora et al.   ADVANCED SYNTHESIS & CATALYSIS

An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones

(2012) Julien Dugal-Tessier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric Intermolecular Stetter Reactions of Enolizable Aldehydes with Nitrostyrenes: Computational Study Provides Insight into the Success of the Catalyst

(2012) Daniel A. DiRocco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nonnatural Amino Acid Synthesis by Using Carbon-Hydrogen Bond Functionalization Methodology

(2012) Ly Dieu Tran et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances and Applications in Organocatalytic Asymmetric aza-Michael Addition

(2012) Jun Wang et al.   ChemCatChem

Desymmetrization of cyclohexadienones viad-camphor-derived triazolium salt catalyzed intramolecular Stetter reaction

(2012) Min-Qiang Jia et al.   CHEMICAL COMMUNICATIONS

Isatins As Privileged Molecules in Design and Synthesis of Spiro-Fused Cyclic Frameworks

(2012) Girija S. Singh et al.   CHEMICAL REVIEWS

From C(sp2)–H to C(sp3)–H: systematic studies on transition metal-catalyzed oxidative C–C formation

(2012) Bi-Jie Li et al.   CHEMICAL SOCIETY REVIEWS

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

Highly Enantioselective Intermolecular Stetter Reaction of Simple Acrylates: Synthesis of α-Chiral γ-Ketoesters

(2012) Nathalie E. Wurz et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic-Carbene-Catalyzed Reaction of α-Bromo-α,β-Unsaturated Aldehyde or α,β-Dibromoaldehyde with Isatins: An Efficient Synthesis of Spirocyclic Oxindole-Dihydropyranones

(2012) Changsheng Yao et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene Catalyzed Reactions of α-Bromo-α,β-unsaturated Aldehydes/α,β-Dibromoaldehydes with 1,3-Dinucleophilic Reagents

(2012) Changsheng Yao et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Diastereoselective, Nucleophile-Promoted Aldol-Lactonization of Ketoacids Leading to Bicyclic-β-Lactones

(2012) Gang Liu et al.   JOURNAL OF ORGANIC CHEMISTRY

Ligand-Enabled Methylene C(sp3)–H Bond Activation with a Pd(II) Catalyst

(2012) Masayuki Wasa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dyotropic Rearrangements of Fused Tricyclic β-Lactones: Application to the Synthesis of (−)-Curcumanolide A and (−)-Curcumalactone

(2012) Carolyn A. Leverett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Sartorymensin, a new indole alkaloid, and new analogues of tryptoquivaline and fiscalins produced by Neosartorya siamensis (KUFC 6349)

(2012) Suradet Buttachon et al.   TETRAHEDRON

NHC-catalyzed cascade synthesis of 1-substituted 4-aryl-tetrahydroquinoline-2,5-diones

(2012) Changsheng Yao et al.   TETRAHEDRON

Oxidative and Enantioselective Cross-Coupling of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether

(2011) Yujiro Hayashi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Practical Strategy for the Structural Diversification of Aliphatic Scaffolds through the Palladium-Catalyzed Picolinamide-Directed Remote Functionalization of Unactivated C(sp3)H Bonds

(2011) Gang He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbene Catalyzed Domino Reactions

(2011) André Grossmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly diastereo- and enantioselective NHC-catalyzed [3+2] annulation of enals and isatins

(2011) Li-Hui Sun et al.   CHEMICAL COMMUNICATIONS

Peptide Coupling Reagents, More than a Letter Soup

(2011) Ayman El-Faham et al.   CHEMICAL REVIEWS

N-Heterocyclic Carbene Catalyzed Reaction of Phthalaldehydes: Controllable Stereoselective Synthesis of Polyhydroxylated Spiro- and Fused Indenones Dictated by the Structure of NHC Catalysts

(2011) Ying Cheng et al.   JOURNAL OF ORGANIC CHEMISTRY

Organocatalytic Functionalization of Carboxylic Acids: Isothiourea-Catalyzed Asymmetric Intra- and Intermolecular Michael Addition−Lactonizations

(2011) Dorine Belmessieri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective, Organocatalyzed, Intramolecular Aldol Lactonizations with Keto Acids Leading to Bi- and Tricyclic β-Lactones and Topology-Morphing Transformations

(2010) Carolyn A. Leverett et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Double Diastereoselective, Nucleophile-Catalyzed Aldol Lactonizations (NCAL) Leading to β-Lactone Fused Carbocycles and Extensions to β-Lactone Fused Tetrahydrofurans

(2010) Kay A. Morris et al.   ORGANIC LETTERS

Dehydrogenation as a Substrate-Activating Strategy in Homogeneous Transition-Metal Catalysis

(2009) Graham E. Dobereiner et al.   CHEMICAL REVIEWS