期刊
CHEMICAL COMMUNICATIONS
卷 52, 期 36, 页码 6162-6165出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cc00705h
关键词
-
资金
- National Natural Science Foundation of China [21272024]
A bifunctional squaramide-catalyzed Michael/Michael cascade reaction for the construction of five-membered spirooxindoles was developed. This reaction afforded the corresponding products with five contiguous stereocenters including a quaternary center in good to excellent yields (up to 93%) with excellent stereoselectivities (up to >99: 1 dr, 98% ee). Meanwhile, the practicality of this methodology was illustrated by a gram-scale synthesis, one-pot four-component reaction and synthetic transformation of the resulting adduct.
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