期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2014, 期 24, 页码 5139-5143出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402687
关键词
Organocatalysis; Asymmetric synthesis; Spiro compounds; Domino reactions; Michael addition
资金
- National Basic Research Program of China (973 Program) [2010CB833300]
- Science and Technology of Hunan Province, China [2012FJ3023]
Spirocyclopentaneoxindole derivatives containing four consecutive stereocenters, including a spiro quaternary center, were constructed by an organocatalytic iminium-enamine cascade sequence in good yields (up to 86%) with excellent enantiomeric (up to >99% ee) and diastereomeric purities (up to >99:1dr). This highly efficient procedure will allow diversity-oriented syntheses of this intriguing class of compounds with potential biological activities.
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