期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 11, 期 9, 页码 1441-1445出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2ob27095a
关键词
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资金
- National Natural Science Foundation of China [91213302, 20932003, 21272102]
- Key National S&T Program Major New Drug Development of the Ministry of Science and Technology of China [2012ZX09504-001-003]
The first organocatalytic double Michael cascade reaction between unsaturated ketones and unsaturated pyrazolones has been developed which provides spiropyrazolone core structures containing two interval or three consecutive stereogenic centers with excellent diastereo-(>20 : 1) and enantioselectivities (up to 99% ee). Moreover, a pair of enantiomers 5 and 5' can be achieved via different catalysts.
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