期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 14, 期 47, 页码 11250-11260出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02104b
关键词
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An organocatalyzed Michael addition-cyclization reaction between 3-isothiocyanatooxindoles and arylidene malonates has been developed for the synthesis of highly functionalized 3,2'-pyrrolidinyl spirooxindole derivatives. The reaction was catalyzed by a quinine derived tertiary amino-thiourea based bifunctional catalyst or its pseudo-enantiomeric quinidine derived catalyst providing both the enantiomers of the desired product. The products were obtained in high yields and with excellent diastereo- (up to 99:1 dr) and enantioselectivities (up to >99% ee).
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