期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2014, 期 26, 页码 5700-5704出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402953
关键词
Organocatalysis; Cycloaddition; Spiro compounds; Alkaloids; Nitrogen heterocycles
资金
- National Natural Science Foundation of China (NSFC) [21175155, 21276282, 21376270]
- Hunan Provincial Science & Technology Department [2012WK2007]
- Central South University
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1363105] Funding Source: National Science Foundation
The enantioselective 1,3-dipolar cycloaddition of 2-cyclohexene-1-one and azomethine ylides generated in situ from isatins and amino esters was developed by employing prolinosulfonamides as the catalyst. Consequently, novel polycyclic spirooxindole scaffolds with three contiguous stereocenters were prepared in high yield (up to 95%) with excellent diastereo-(>20:1dr) and enantioselectivity (up to 99% ee).
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