N-Heterocyclic carbene-catalyzed [3 + 2] annulation of bromoenals with 3-aminooxindoles: highly enantioselective synthesis of spirocyclic oxindolo-γ-lactams

Design and synthesis of new bioisosteres of spirooxindoles (MI-63/219) as anti-breast cancer agents

(2015) Atul Kumar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Facile and diastereoselective synthesis of 3,2′-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities

(2015) D. Kathirvelan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Heterocyclic carbene-catalyzed [3+3] cyclocondensation of bromoenals with aldimines: highly enantioselective synthesis of dihydropyridinones

(2015) Zhong-Hua Gao et al.   CHEMICAL COMMUNICATIONS

Nucleophilic β-Carbon Activation of Propionic Acid as a 3-Carbon Synthon by Carbene Organocatalysis

(2015) Zhichao Jin et al.   CHEMISTRY-A EUROPEAN JOURNAL

An NHC-Catalyzed In Situ Activation Strategy to β-Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+2] Annulation for Spirocyclic Oxindolo-γ-butyrolactones

(2015) Yuanwei Xie et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene-Catalyzed Formal [3 + 2] Annulation of α-Bromoenals with 3-Aminooxindoles: A Stereoselective Synthesis of Spirooxindole γ-Butyrolactams

(2015) Delu Jiang et al.   JOURNAL OF ORGANIC CHEMISTRY

A strategic approach to the synthesis of functionalized spirooxindole pyrrolidine derivatives: in vitro antibacterial, antifungal, antimalarial and antitubercular studies

(2015) Saoussen Haddad et al.   NEW JOURNAL OF CHEMISTRY

N-heterocyclic carbene-catalyzed cyclocondensation of 2-aryl carboxylic acids and enones: highly enantioselective synthesis of δ-lactones

(2015) Jin-Tang Cheng et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-Heterocyclic carbene-catalyzed [3 + 3] cyclocondensation of bromoenals with hydrazones: highly enantioselective synthesis of dihydropyridazones

(2015) Chun-Lin Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Asymmetric N-Heterocyclic Carbene-catalyzed [4+2] Cycloaddition of Ketenes with α-cyanochalcones

(2015) Lihui Sun et al.   ACTA CHIMICA SINICA

N-Heterocyclic Carbene Catalyzed Cyclocondensation of α,β-Unsaturated Carboxylic Acids: Enantioselective Synthesis of Pyrrolidinone and Dihydropyridinone Derivatives

(2014) Xiang-Yu Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel spirooxindole–pyrrolidine compounds: Synthesis, anticancer and molecular docking studies

(2014) Y. Arun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Tandem Michael Addition–Ring Transformation Reactions of 3-Hydroxyoxindoles/3-Aminooxindoles with Olefinic Azlactones: Direct Access to Structurally Diverse Spirocyclic Oxindoles

(2014) Bao-Dong Cui et al.   JOURNAL OF ORGANIC CHEMISTRY

An overview of N-heterocyclic carbenes

(2014) Matthew N. Hopkinson et al.   NATURE

Enantioselective N-Heterocyclic Carbene-Catalyzed Annulations of 2-Bromoenals with 1,3-Dicarbonyl Compounds and EnaminesviaChiral α,β-Unsaturated Acylazoliums

(2013) Santhivardhana Reddy Yetra et al.   ADVANCED SYNTHESIS & CATALYSIS

N-tert-Butyl Triazolylidenes: Catalysts for the Enantioselective (3+2) Annulation of α,β-Unsaturated Acyl Azoliums

(2013) Lisa Candish et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC Organocatalytic Formal LUMO Activation of α,β-Unsaturated Esters for Reaction with Enamides

(2013) Jiajia Cheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic asymmetric multicomponent cascade reaction via 1,3-proton shift and [3+2] cycloaddition: an efficient strategy for the synthesis of oxindole derivatives

(2013) Li Tian et al.   CHEMICAL COMMUNICATIONS

Acyl anion free N-heterocyclic carbene organocatalysis

(2013) Sarah J. Ryan et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene Catalyzed [4+2] Cycloaddition of Nitroalkenes with Oxodienes

(2013) Xiang-Yu Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic carbene-catalyzed synthesis of acetyltributylcitrate via a transesterification reaction

(2013) Lin He et al.   CHINESE CHEMICAL LETTERS

Synthesis of novel spirooxindolo-pyrrolidines, pyrrolizidines, and pyrrolothiazoles via a regioselective three-component [3+2] cycloaddition and their preliminary antimicrobial evaluation

(2013) Guansheng Wu et al.   MOLECULAR DIVERSITY

β-Carbon activation of saturated carboxylic esters through N-heterocyclic carbene organocatalysis

(2013) Zhenqian Fu et al.   Nature Chemistry

Asymmetric N-Heterocyclic Carbene (NHC)-Catalyzed Annulation of Modified Enals with Enolizable Aldehydes

(2013) Santhivardhana Reddy Yetra et al.   ORGANIC LETTERS

Asymmetric Access to the Smallest Enolate Intermediate via Organocatalytic Activation of Acetic Ester

(2013) Shaojin Chen et al.   ORGANIC LETTERS

Enantioselective, NHC-Catalyzed Annulations of Trisubstituted Enals and CyclicN-Sulfonylimines via α,β-Unsaturated Acyl Azoliums

(2012) Alberto G. Kravina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic umpolung: N-heterocyclic carbenes and beyond

(2012) Xavier Bugaut et al.   CHEMICAL SOCIETY REVIEWS

N-Heterocyclic Carbene-Catalyzed Homoenolate Additions with N-Aryl Ketimines as Electrophiles: Efficient Synthesis of Spirocyclic γ-Lactam Oxindoles

(2012) Bo Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene Catalyzed Reactions of α-Bromo-α,β-unsaturated Aldehydes/α,β-Dibromoaldehydes with 1,3-Dinucleophilic Reagents

(2012) Changsheng Yao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Scaffold-Inspired Enantioselective Synthesis of Biologically Important Spiro[pyrrolidin-3,2′-oxindoles] with Structural Diversity through Catalytic Isatin-Derived 1,3-Dipolar Cycloadditions

(2012) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

N-Heterocyclic Carbene-Catalyzed Ireland–Coates Claisen Rearrangement: Synthesis of Functionalized β-Lactones

(2012) Lisa Candish et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Activation of Stable Carboxylate Esters as Enolate Equivalents via N-Heterocyclic Carbene Catalysts

(2012) Lin Hao et al.   ORGANIC LETTERS

Highly Enantioselective Addition of Enals to Isatin-Derived Ketimines Catalyzed by N-Heterocyclic Carbenes: Synthesis of Spirocyclic γ-Lactams

(2012) Hui Lv et al.   ORGANIC LETTERS

Chiral N-Heterocyclic Carbene-Catalyzed Annulations of Enals and Ynals with Stable Enols: A Highly Enantioselective Coates–Claisen Rearrangement

(2012) Jessada Mahatthananchai et al.   ACS Catalysis

N-Heterocyclic Carbene-Catalyzed Enantioselective Annulation of Bromoenal and 1,3-Dicarbonyl Compounds

(2011) Fang-Gang Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

N-Heterocyclic Carbene Catalyzed Umpolung of Michael Acceptors for Intermolecular Reactions

(2011) Akkattu T. Biju et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral N-heterocyclic carbene catalyzed annulation of α,β-unsaturated aldehydes with 1,3-dicarbonyls

(2011) Zhi-Qiang Zhu et al.   CHEMICAL COMMUNICATIONS

N-Heterocyclic Carbene-Mediated Oxidative Esterification of Aldehydes: Ester Formation and Mechanistic Studies

(2011) Biswajit Maji et al.   JOURNAL OF ORGANIC CHEMISTRY

N-Heterocyclic Carbene-Catalyzed (4 + 2) Cycloaddition/Decarboxylation of Silyl Dienol Ethers with α,β-Unsaturated Acid Fluorides

(2011) Sarah J. Ryan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of Dihydropyridinones via NHC-Catalyzed Aza-Claisen Reaction

(2011) Benedikt Wanner et al.   ORGANIC LETTERS

EnantioselectiveN-Heterocyclic Carbene-Catalyzed Michael Addition to α,β-Unsaturated Aldehydes by Redox Oxidation

(2011) Zi-Qiang Rong et al.   ORGANIC LETTERS

Organocatalytic Tail-to-Tail Dimerization of Olefin: Umpolung of Methyl Methacrylate Mediated by N-Heterocyclic Carbene

(2011) Shin-ichi Matsuoka et al.   ORGANIC LETTERS

N-heterocyclic carbene-catalyzed rearrangements of vinyl sulfones

(2011) Roxanne L. Atienza et al.   Chemical Science

Formal [3+2] Cycloaddition of Ketenes and Oxaziridines Catalyzed by Chiral Lewis Bases: Enantioselective Synthesis of Oxazolin-4-ones

(2010) Pan-Lin Shao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-Catalyzed Michael Addition to α,β-Unsaturated Aldehydes by Redox Activation

(2010) Suman De Sarkar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes

(2010) XueLiang Huang et al.   CHINESE SCIENCE BULLETIN

3-Alkenyl-oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches

(2010) Alessia Millemaggi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

An Enantioselective Claisen Rearrangement Catalyzed by N-Heterocyclic Carbenes

(2010) Juthanat Kaeobamrung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-Heterocyclic Carbene-Catalyzed Generation of α,β-Unsaturated Acyl Imidazoliums: Synthesis of Dihydropyranones by their Reaction with Enolates

(2009) Sarah J. Ryan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products

(2009) Barry Trost et al.   SYNTHESIS-STUTTGART

Enantioselective Synthesis ofcis-4-Formyl-β-lactamsviaChiral N-Heterocyclic Carbene-Catalyzed Kinetic Resolution

(2008) Gong-Qiang Li et al.   ADVANCED SYNTHESIS & CATALYSIS

[4+2] Cycloaddition of Ketenes withN-Benzoyldiazenes Catalyzed by N-Heterocyclic Carbenes

(2008) Xue-Liang Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomimetic Carbene-Catalyzed Oxidations of Aldehydes Using TEMPO

(2008) Joyram Guin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective synthesis of dispiro[1H-indene-2,3′-pyrrolidine-2′,3″-[3H]indole]-1,2″(1″H)-diones of potential anti-tumor properties

(2008) Adel S. Girgis   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

N-Heterocyclic carbene catalysed β-lactam synthesis

(2008) Nicolas Duguet et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chiral N-Heterocyclic Carbene Catalyzed Staudinger Reaction of Ketenes with Imines:  Highly Enantioselective Synthesis ofN-Boc β-Lactams

(2007) Yan-Rong Zhang et al.   ORGANIC LETTERS