标题
The making of bispecific antibodies
作者
关键词
-
出版物
mAbs
Volume 9, Issue 2, Pages 182-212
出版商
Informa UK Limited
发表日期
2017-01-10
DOI
10.1080/19420862.2016.1268307
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Phase II study of capecitabine in substitution of 5-FU in the chemoradiotherapy regimen for patients with squamous cell carcinoma of the anal canal.
- (2017) Suilane Coelho Ribeiro et al. JOURNAL OF CLINICAL ONCOLOGY
- Tetravalent anti-CD20/CD3 bispecific antibody for the treatment of B cell lymphoma
- (2016) Chia-Yen Lu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Drug Development of Therapeutic Monoclonal Antibodies
- (2016) Diane R. Mould et al. BIODRUGS
- Determination of critical quality attributes for monoclonal antibodies using quality by design principles
- (2016) Nadja Alt et al. BIOLOGICALS
- Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity
- (2016) Yaoxing Huang et al. CELL
- Characterization of CD33/CD3 Tetravalent Bispecific Tandem Diabodies (TandAbs) for the Treatment of Acute Myeloid Leukemia
- (2016) U. Reusch et al. CLINICAL CANCER RESEARCH
- A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors
- (2016) M. Bacac et al. CLINICAL CANCER RESEARCH
- The SAATELLITE and EVADE Clinical Studies Within the COMBACTE Consortium: A Public–Private Collaborative Effort in Designing and Performing Clinical Trials for Novel Antibacterial Drugs to Prevent Nosocomial Pneumonia: Table 1.
- (2016) Bruno François et al. CLINICAL INFECTIOUS DISEASES
- Bispecific antibodies and CARs: generalized immunotherapeutics harnessing T cell redirection
- (2016) Eugene A Zhukovsky et al. CURRENT OPINION IN IMMUNOLOGY
- Editorial overview: Special section: New concepts in antibody therapeutics: What's in store for antibody therapy?
- (2016) Janine Schuurman et al. CURRENT OPINION IN IMMUNOLOGY
- Re-engineering therapeutic antibodies for Alzheimer’s disease as blood-brain barrier penetrating bi-specific antibodies
- (2016) William M. Pardridge EXPERT OPINION ON BIOLOGICAL THERAPY
- Engineered IgG1-Fc - one fragment to bind them all
- (2016) Elisabeth Lobner et al. IMMUNOLOGICAL REVIEWS
- Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies
- (2016) Josée Golay et al. JOURNAL OF IMMUNOLOGY
- Melanoma-Directed Activation of Apoptosis Using a Bispecific Antibody Directed at MCSP and TRAIL Receptor-2/Death Receptor-5
- (2016) Yuan He et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Development of purification processes for fully human bispecific antibodies based upon modification of protein A binding avidity
- (2016) Andrew D. Tustian et al. mAbs
- CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications
- (2016) Anke Steinmetz et al. mAbs
- Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding
- (2016) Emma Davé et al. mAbs
- Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies
- (2016) Tetyana Dashivets et al. mAbs
- The use of CrossMAb technology for the generation of bi- and multispecific antibodies
- (2016) Christian Klein et al. mAbs
- RG7386, a Novel Tetravalent FAP-DR5 Antibody, Effectively Triggers FAP-Dependent, Avidity-Driven DR5 Hyperclustering and Tumor Cell Apoptosis
- (2016) P. Bru nker et al. MOLECULAR CANCER THERAPEUTICS
- Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
- (2016) Jonas Kloepper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations
- (2016) Raffaella Castoldi et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Computationally Designed Bispecific Antibodies using Negative State Repertoires
- (2016) Andrew Leaver-Fay et al. STRUCTURE
- Bispecific antibody mimicking factor VIII
- (2016) Keiji Nogami THROMBOSIS RESEARCH
- A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
- (2016) Monica Florio et al. Nature Communications
- Bispecific Antibody Conjugated Manganese-Based Magnetic Engineered Iron Oxide for Imaging of HER2/neu- and EGFR-Expressing Tumors
- (2016) Shou-Cheng Wu et al. Theranostics
- Overcoming the Constraints of Anti-HIV/CD89 Bispecific Antibodies That Limit Viral Inhibition
- (2016) Xiaocong Yu et al. Journal of Immunology Research
- A single-domain antibody-linked Fab bispecific antibody Her2-S-Fab has potent cytotoxicity against Her2-expressing tumor cells
- (2016) Aifen Li et al. AMB Express
- The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy
- (2015) Jonathan T. Sockolosky et al. ADVANCED DRUG DELIVERY REVIEWS
- Advances in Antibody Design
- (2015) Kathryn E. Tiller et al. Annual Review of Biomedical Engineering
- A phase 1 study of the bispecific anti-CD30/CD16A antibody construct AFM13 in patients with relapsed or refractory Hodgkin lymphoma
- (2015) A. Rothe et al. BLOOD
- Safety and Pharmacokinetics/Pharmacodynamics of the First-in-Class Dual Action HER3/EGFR Antibody MEHD7945A in Locally Advanced or Metastatic Epithelial Tumors
- (2015) D. Juric et al. CLINICAL CANCER RESEARCH
- Bispecific antibodies
- (2015) Roland E. Kontermann et al. DRUG DISCOVERY TODAY
- Utilizing the BiTE (bispecific T-cell engager) platform for immunotherapy of cancer
- (2015) Julia Stieglmaier et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- TriFabs—Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery
- (2015) Klaus Mayer et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A Novel Antibody Engineering Strategy for Making Monovalent Bispecific Heterodimeric IgG Antibodies by Electrostatic Steering Mechanism
- (2015) Zhi Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor
- (2015) Benjamin T. Walters et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A bispecific antibody directly induces lymphoma cell death by simultaneously targeting CD20 and HLA-DR
- (2015) Jing Zeng et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- An Improved Single-Chain Fab Platform for Efficient Display and Recombinant Expression
- (2015) James T. Koerber et al. JOURNAL OF MOLECULAR BIOLOGY
- Developability Assessment During the Selection of Novel Therapeutic Antibodies
- (2015) Alexander Jarasch et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study
- (2015) Max S Topp et al. LANCET ONCOLOGY
- Functional assessment of antibody oxidation by native mass spectrometry
- (2015) Markus Haberger et al. mAbs
- Fab-based bispecific antibody formats with robust biophysical properties and biological activity
- (2015) Xiufeng Wu et al. mAbs
- Improving target cell specificity using a novel monovalent bispecific IgG design
- (2015) Yariv Mazor et al. mAbs
- Insights into the molecular basis of a bispecific antibody's target selectivity
- (2015) Yariv Mazor et al. mAbs
- A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells
- (2015) Emily C Piccione et al. mAbs
- Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies
- (2015) Xiufeng Wu et al. mAbs
- A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation
- (2015) Yang Shen et al. mAbs
- Heavy and light chain pairing of bivalent quadroma and knobs-into-holes antibodies analyzed by UHR-ESI-QTOF mass spectrometry
- (2015) Wolfgang Schaefer et al. mAbs
- Pharmacokinetic properties of IgG and various Fc fusion proteins in mice
- (2015) Felix Unverdorben et al. mAbs
- Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases
- (2015) Michela Silacci et al. mAbs
- Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β
- (2015) Susan E Lacy et al. mAbs
- Dual Agonist Surrobody Simultaneously Activates Death Receptors DR4 and DR5 to Induce Cancer Cell Death
- (2015) S. Milutinovic et al. MOLECULAR CANCER THERAPEUTICS
- Crystal structures of immunoglobulin Fc heterodimers reveal the molecular basis for heterodimer formation
- (2015) Hye-Ji Choi et al. MOLECULAR IMMUNOLOGY
- ImmTACs for targeted cancer therapy: Why, what, how, and which
- (2015) Joanne Oates et al. MOLECULAR IMMUNOLOGY
- Alternative molecular formats and therapeutic applications for bispecific antibodies
- (2015) Christoph Spiess et al. MOLECULAR IMMUNOLOGY
- Amgen's bispecific antibody puffs across finish line
- (2015) Cormac Sheridan NATURE BIOTECHNOLOGY
- Identification of Anti-EGFR and Anti-ErbB3 Dual Variable Domains Immunoglobulin (DVD-Ig) Proteins with Unique Activities
- (2015) Jinming Gu et al. PLoS One
- Engineering of Immunoglobulin Fc Heterodimers Using Yeast Surface-Displayed Combinatorial Fc Library Screening
- (2015) Hye-Ji Choi et al. PLoS One
- Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+ Colorectal Cancer Cells
- (2015) J. U. Schmohl et al. Targeted Oncology
- The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis
- (2015) Maarten Van Roy et al. ARTHRITIS RESEARCH & THERAPY
- Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG
- (2015) Nicolas Fischer et al. Nature Communications
- A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys
- (2015) Eric J. Smith et al. Scientific Reports
- Rational Design of Antirheumatic Prodrugs Specific for Sites of Inflammation
- (2015) Shimobi C. Onuoha et al. Arthritis & Rheumatology
- Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody
- (2015) Mahiuddin Ahmed et al. OncoImmunology
- A review of blinatumomab, a novel immunotherapy
- (2015) Matthew J Newman et al. JOURNAL OF ONCOLOGY PHARMACY PRACTICE
- ImmTAC-redirected tumour cell killing induces and potentiates antigen cross-presentation by dendritic cells
- (2014) Giovanna Bossi et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Four-in-One Antibodies Have Superior Cancer Inhibitory Activity against EGFR, HER2, HER3, and VEGF through Disruption of HER/MET Crosstalk
- (2014) S. Hu et al. CANCER RESEARCH
- Antitumor Efficacy of a Bispecific Antibody That Targets HER2 and Activates T Cells
- (2014) T. T. Junttila et al. CANCER RESEARCH
- Bispecific antibody platforms for cancer immunotherapy
- (2014) Roeland Lameris et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- 138 Preclinical activity and safety of MGD006, a CD123xCD3 Bispecific DART® molecule for the treatment of hematological malignancies
- (2014) P. Moore et al. EUROPEAN JOURNAL OF CANCER
- 139 GBR1302: a BEAT® bispecific antibody for the treatment of HER2 positive cancers
- (2014) A. Croset et al. EUROPEAN JOURNAL OF CANCER
- Bispecific T-cell engagers for cancer immunotherapy
- (2014) Amelia M Huehls et al. IMMUNOLOGY AND CELL BIOLOGY
- Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer
- (2014) Jayakumar S. Poovassery et al. INTERNATIONAL JOURNAL OF CANCER
- A Novel Glycoengineered Bispecific Antibody Format for Targeted Inhibition of Epidermal Growth Factor Receptor (EGFR) and Insulin-like Growth Factor Receptor Type I (IGF-1R) Demonstrating Unique Molecular Properties
- (2014) Juergen M. Schanzer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice
- (2014) Zhiyong Yang et al. JOURNAL OF INFECTIOUS DISEASES
- A novel tetravalent bispecific TandAb (CD30/CD16A) efficiently recruits NK cells for the lysis of CD30+tumor cells
- (2014) Uwe Reusch et al. mAbs
- A Two-in-One antibody engineered from a humanized interleukin 4 antibody through mutation in heavy chain complementarity-determining regions
- (2014) Chingwei V Lee et al. mAbs
- Production of bispecific antibodies in “knobs-into-holes” using a cell-free expression system
- (2014) Yiren Xu et al. mAbs
- Nanocell targeting using engineered bispecific antibodies
- (2014) Karin Taylor et al. mAbs
- Assessment of chemical modifications of sites in the CDRs of recombinant antibodies
- (2014) Markus Haberger et al. mAbs
- A Bispecific HER2-Targeting FynomAb with Superior Antitumor Activity and Novel Mode of Action
- (2014) S. Brack et al. MOLECULAR CANCER THERAPEUTICS
- Preclinical Evaluation of Multistep Targeting of Diasialoganglioside GD2 Using an IgG-scFv Bispecific Antibody with High Affinity for GD2 and DOTA Metal Complex
- (2014) S. M. Cheal et al. MOLECULAR CANCER THERAPEUTICS
- Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface
- (2014) Steven M Lewis et al. NATURE BIOTECHNOLOGY
- Controlled Fab-arm exchange for the generation of stable bispecific IgG1
- (2014) Aran F Labrijn et al. Nature Protocols
- Bispecific antibodies rise again
- (2014) Ken Garber NATURE REVIEWS DRUG DISCOVERY
- Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle
- (2014) Jens Niewoehner et al. NEURON
- Identification of Anti-ErbB2 Dual Variable Domain Immunoglobulin (DVD-Ig™) Proteins with Unique Activities
- (2014) Jinming Gu et al. PLoS One
- A multifunctional bispecific antibody protects against Pseudomonas aeruginosa
- (2014) A. DiGiandomenico et al. Science Translational Medicine
- Tumor-Antigen–Binding Bispecific Antibodies for Cancer Treatment
- (2014) Ulrich H. Weidle et al. SEMINARS IN ONCOLOGY
- IgG Subclasses and Allotypes: From Structure to Effector Functions
- (2014) Gestur Vidarsson et al. Frontiers in Immunology
- Albumin as a versatile platform for drug half-life extension
- (2013) Darrell Sleep et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines
- (2013) Christoph Spiess et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Bispecific Her2 × cotinine antibody in combination with cotinine–(histidine)2–iodine for the pre-targeting of Her2-positive breast cancer xenografts
- (2013) Soomin Yoon et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Protection by Immunoglobulin Dual-Affinity Retargeting Antibodies against Dengue Virus
- (2013) J. D. Brien et al. JOURNAL OF VIROLOGY
- LC-MS characterization and purity assessment of a prototype bispecific antibody
- (2013) R. Jeremy Woods et al. mAbs
- CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery
- (2013) Brian J Fennell et al. mAbs
- The structure of dual-variable-domain immunoglobulin molecules alone and bound to antigen
- (2013) Ivan Correia et al. mAbs
- Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity
- (2013) Whitney Shatz et al. mAbs
- Production of stable bispecific IgG1 by controlled Fab-arm exchange
- (2013) Michael J Gramer et al. mAbs
- Monoclonal antibody therapeutics with up to five specificities: Functional enhancement through fusion of target-specific peptides
- (2013) David LaFleur et al. mAbs
- Improving biophysical properties of a bispecific antibody scaffold to aid developability
- (2013) Thomas Spreter Von Kreudenstein et al. mAbs
- A new class of bispecific antibodies to redirect T cells for cancer immunotherapy
- (2013) Diane L Rossi et al. mAbs
- Engineering multivalent antibodies to target heregulin-induced HER3 signaling in breast cancer cells
- (2013) Jeffrey C Kang et al. mAbs
- Structure reveals function of the dual variable domain immunoglobulin (DVD-Ig™) molecule
- (2013) Clarissa G. Jakob et al. mAbs
- An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
- (2013) Omid Vafa et al. METHODS
- Single-Domain Antibody-Based and Linker-Free Bispecific Antibodies Targeting Fc RIII Induce Potent Antitumor Activity without Recruiting Regulatory T Cells
- (2013) C. Rozan et al. MOLECULAR CANCER THERAPEUTICS
- A Heterodimeric Fc-Based Bispecific Antibody Simultaneously Targeting VEGFR-2 and Met Exhibits Potent Antitumor Activity
- (2013) H.-J. Choi et al. MOLECULAR CANCER THERAPEUTICS
- Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor
- (2013) C. Chen et al. MOLECULAR CANCER THERAPEUTICS
- Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies
- (2013) Christoph Spiess et al. NATURE BIOTECHNOLOGY
- Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity
- (2013) Zenjiro Sampei et al. PLoS One
- Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody
- (2013) Lei Wang et al. PLoS One
- Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange
- (2013) A. F. Labrijn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
- (2013) M. Merchant et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Quantification of cell surface proteins with bispecific antibodies
- (2013) C. Panke et al. PROTEIN ENGINEERING DESIGN & SELECTION
- A tale of two specificities: bispecific antibodies for therapeutic and diagnostic applications
- (2013) Hannah Byrne et al. TRENDS IN BIOTECHNOLOGY
- Anti-EGFR biparatopic-SEED antibody has enhanced combination-activity in a single molecule
- (2012) Christie Kelton et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Development of tetravalent IgG1 dual targeting IGF-1R–EGFR antibodies with potent tumor inhibition
- (2012) Rebecca Croasdale et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast
- (2012) Michael W. Traxlmayr et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Optimization of Multivalent Bispecific Antibodies and Immunocytokines with Improved in Vivo Properties
- (2012) Edmund A. Rossi et al. BIOCONJUGATE CHEMISTRY
- Dual-targeting immunotherapy of lymphoma: potent cytotoxicity of anti-CD20/CD74 bispecific antibodies in mantle cell and other lymphomas
- (2012) P. Gupta et al. BLOOD
- Immunopharmacologic response of patients with B-lineage acute lymphoblastic leukemia to continuous infusion of T cell-engaging CD19/CD3-bispecific BiTE antibody blinatumomab
- (2012) M. Klinger et al. BLOOD
- Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation
- (2012) S. Huang et al. CANCER RESEARCH
- scFv Antibody: Principles and Clinical Application
- (2012) Zuhaida Asra Ahmad et al. Clinical & Developmental Immunology
- Monoclonal antibodies: what are the pharmacokinetic and pharmacodynamic considerations for drug development?
- (2012) Rong Deng et al. Expert Opinion on Drug Metabolism & Toxicology
- LUZ-Y, a Novel Platform for the Mammalian Cell Production of Full-length IgG-bispecific Antibodies
- (2012) Bernd J. Wranik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair
- (2012) Pavel Strop et al. JOURNAL OF MOLECULAR BIOLOGY
- A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens
- (2012) Gregory L. Moore et al. mAbs
- Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis
- (2012) Palanisamy Kanakaraj et al. mAbs
- Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies
- (2012) Christian Klein et al. mAbs
- World Bispecific Antibody Summit, September 27–28, 2011, Boston, MA
- (2012) Eugen Dhimolea et al. mAbs
- Dual targeting strategies with bispecific antibodies
- (2012) Roland Kontermann mAbs
- ErbB3 Inhibitory Surrobodies Inhibit Tumor Cell Proliferation In Vitro and In Vivo
- (2012) P. K. Foreman et al. MOLECULAR CANCER THERAPEUTICS
- Antitumor Activity of a Novel Bispecific Antibody That Targets the ErbB2/ErbB3 Oncogenic Unit and Inhibits Heregulin-Induced Activation of ErbB3
- (2012) C. F. McDonagh et al. MOLECULAR CANCER THERAPEUTICS
- Blinatumomab: A historical perspective
- (2012) Dirk Nagorsen et al. PHARMACOLOGY & THERAPEUTICS
- Stabilisation of the Fc Fragment of Human IgG1 by Engineered Intradomain Disulfide Bonds
- (2012) Gordana Wozniak-Knopp et al. PLoS One
- Anti-HIV Double Variable Domain Immunoglobulins Binding Both gp41 and gp120 for Targeted Delivery of Immunoconjugates
- (2012) Ryan B. Craig et al. PLoS One
- The IgM CH2 domain as covalently linked homodimerization module for the generation of fusion proteins with dual specificity
- (2012) O. Seifert et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Molecular characterization of novel trispecific ErbB-cMet-IGF1R antibodies and their antigen-binding properties
- (2012) R. Castoldi et al. PROTEIN ENGINEERING DESIGN & SELECTION
- A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance
- (2012) P. J. Yazaki et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing
- (2012) S. Metz et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Directed evolution of Her2/neu-binding IgG1-Fc for improved stability and resistance to aggregation by using yeast surface display
- (2012) Michael W. Traxlmayr et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Complex and defined biostructures with the dock-and-lock method
- (2012) Edmund A. Rossi et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Development of Tetravalent, Bispecific CCR5 Antibodies with Antiviral Activity against CCR5 Monoclonal Antibody-Resistant HIV-1 Strains
- (2011) Jürgen Schanzer et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Dock-and-Lock Method Combines Recombinant Engineering with Site-Specific Covalent Conjugation To Generate Multifunctional Structures
- (2011) Edmund A. Rossi et al. BIOCONJUGATE CHEMISTRY
- A Two-in-One Antibody against HER3 and EGFR Has Superior Inhibitory Activity Compared with Monospecific Antibodies
- (2011) Gabriele Schaefer et al. CANCER CELL
- Heterodimeric bispecific antibody-derivatives against CD19 and CD16 induce effective antibody-dependent cellular cytotoxicity against B-lymphoid tumor cells
- (2011) Christian Kellner et al. CANCER LETTERS
- Strategies for extended serum half-life of protein therapeutics
- (2011) Roland E Kontermann CURRENT OPINION IN BIOTECHNOLOGY
- A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
- (2011) Jianying Dong et al. mAbs
- Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design
- (2011) Enrico L. DiGiammarino et al. mAbs
- A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting
- (2011) Ingo Schubert et al. mAbs
- Unexpected recombinations in single chain bispecific anti-CD3–anti-CD33 antibodies can be avoided by a novel linker module
- (2011) Slava Stamova et al. MOLECULAR IMMUNOLOGY
- In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody
- (2011) Izumi Kumagai ONCOLOGY REPORTS
- High Affinity Antigen Recognition of the Dual Specific Variants of Herceptin Is Entropy-Driven in Spite of Structural Plasticity
- (2011) Jenny Bostrom et al. PLoS One
- Bispecific digoxigenin-binding antibodies for targeted payload delivery
- (2011) S. Metz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies
- (2011) M. Muda et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias
- (2010) P. Gupta et al. BLOOD
- A recombinant trispecific single-chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting
- (2010) Markus Kügler et al. BRITISH JOURNAL OF HAEMATOLOGY
- Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity
- (2010) Jianying Dong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling
- (2010) Janet Jackman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects
- (2010) Kannan Gunasekaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Effector Cell Recruitment with Novel Fv-based Dual-affinity Re-targeting Protein Leads to Potent Tumor Cytolysis and in Vivo B-cell Depletion
- (2010) Syd Johnson et al. JOURNAL OF MOLECULAR BIOLOGY
- Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR
- (2010) Jennifer S. Michaelson et al. mAbs
- IgG2m4, an engineered antibody isotype with reduced Fc function
- (2010) Zhiqiang An et al. mAbs
- Bispecific antibodies for cancer therapy
- (2010) Patrick Chames et al. mAbs
- Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules
- (2010) Chengbin Wu et al. mAbs
- Oligomeric forms of single chain immunoglobulin (scIgG)
- (2010) Thomas Schirrmann et al. mAbs
- Structural and functional characterization of the trifunctional antibody catumaxomab
- (2010) Dirk Chelius et al. mAbs
- Humanization of a Mouse Monoclonal Antibody Directed Against a Cell Surface-Exposed Epitope of Membrane-Associated Heat Shock Protein 70 (Hsp70)
- (2010) Kirstin A. Zettlitz et al. MOLECULAR BIOTECHNOLOGY
- Chemical generation of bispecific antibodies
- (2010) V. R. Doppalapudi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties
- (2010) G. Wozniak-Knopp et al. PROTEIN ENGINEERING DESIGN & SELECTION
- VH/VL interface engineering to promote selective expression and inhibit conformational isomerization of thrombopoietin receptor agonist single-chain diabody
- (2010) T. Igawa et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Stability engineering of scFvs for the development of bispecific and multivalent antibodies
- (2010) Brian R. Miller et al. PROTEIN ENGINEERING DESIGN & SELECTION
- SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies†
- (2010) Jonathan H. Davis et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Remodeling domain interfaces to enhance heterodimer formation
- (2010) Zhenping Zhu et al. PROTEIN SCIENCE
- Recombinant Bispecific Monoclonal Antibodies Prepared by the Dock-and-Lock Strategy for Pretargeted Radioimmunotherapy
- (2010) Robert M. Sharkey et al. SEMINARS IN NUCLEAR MEDICINE
- Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma
- (2009) E. A. Rossi et al. BLOOD
- Bispecific T-Cell Engaging Antibodies for Cancer Therapy
- (2009) P. A. Baeuerle et al. CANCER RESEARCH
- The Design and Characterization of Oligospecific Antibodies for Simultaneous Targeting of Multiple Disease Mediators
- (2009) Nazzareno Dimasi et al. JOURNAL OF MOLECULAR BIOLOGY
- Pharmacokinetics and Brain Uptake of a Genetically Engineered Bifunctional Fusion Antibody Targeting the Mouse Transferrin Receptor
- (2009) Ruben J. Boado et al. MOLECULAR PHARMACEUTICS
- Engineering of stable bispecific antibodies targeting IL-17A and IL-23
- (2009) Robert Mabry et al. PROTEIN ENGINEERING DESIGN & SELECTION
- A modular IgG-scFv bispecific antibody topology
- (2009) Kelly Davis Orcutt et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site
- (2009) J. Bostrom et al. SCIENCE
- Structural characterization of a human Fc fragment engineered for lack of effector functions
- (2008) Vaheh Oganesyan et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Improved Therapeutic Results by Pretargeted Radioimmunotherapy of Non-Hodgkin's Lymphoma with a New Recombinant, Trivalent, Anti-CD20, Bispecific Antibody
- (2008) R. M. Sharkey et al. CANCER RESEARCH
- Single-domain antibodies as building blocks for novel therapeutics
- (2008) D SAERENS et al. CURRENT OPINION IN PHARMACOLOGY
- A Novel CD19-directed Recombinant Bispecific Antibody Derivative With Enhanced Immune Effector Functions for Human Leukemic Cells
- (2008) Christian Kellner et al. JOURNAL OF IMMUNOTHERAPY
- Combinatorial surrobody libraries
- (2008) L. Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Passive immunization of pigs with bispecific llama single-domain antibody fragments against foot-and-mouth disease and porcine immunoglobulin
- (2008) M.M. Harmsen et al. VETERINARY MICROBIOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started