Article
Multidisciplinary Sciences
Theresa Kissel, Changrong Ge, Lise Hafkenscheid, Joanneke C. Kwekkeboom, Linda M. Slot, Marco Cavallari, Yibo He, Karin A. van Schie, Rochelle D. Vergroesen, Arieke S. B. Kampstra, Sanne Reijm, Gerrie Stoeken-Rijsbergen, Carolien Koeleman, Lennard M. Voortman, Laura H. Heitman, Bingze Xu, Ger J. M. Pruijn, Manfred Wuhrer, Theo Rispens, Tom W. J. Huizinga, Hans Ulrich Scherer, Michael Reth, Rikard Holmdahl, Rene E. M. Toes
Summary: The presence of variable domain glycans (VDGs) in autoantibodies in rheumatoid arthritis affects B cell activation and binding, potentially contributing to the breach of tolerance in autoimmune diseases.
Article
Biochemistry & Molecular Biology
Pankaj Kumar, Pallavi Vyas, Syed M. Faisal, Yung-Fu Chang, Mohd Akif
Summary: This study described the high-resolution crystal structure of a variable region segment (LigA8-9) of the Leptospiral immunoglobulin-like (Lig) protein. The structure showed distinctive aspects compared to other similar Immunoglobulin domains and highlighted the role of the linker region in domain orientation. This research is important for understanding the interaction between the extracellular portion of LigA protein and the host's extracellular matrices, as well as developing new therapeutics for leptospirosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Chuanliang Liu, Yonglun Zeng, Hongbo Li, Chao Yang, Wenjin Shen, Min Xu, Zhidan Xiao, Tongsheng Chen, Baiying Li, Wenhan Cao, Liwen Jiang, Marisa S. Otegui, Caiji Gao
Summary: The study identified FYVE4 as a novel plant endosomal regulator, functioning in the ESCRT pathway to regulate MVE biogenesis.
Article
Immunology
Yixun Huang, Linnea Thornqvist, Mats Ohlin
Summary: The study has redefined upstream regions of immunoglobulin genes using large transcriptome data sets, identifying new upstream regions and validating several novel variants.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
David Fernandez-Martinez, Mark D. Tully, Gordon Leonard, Magali Mathieu, Eaazhisai Kandiah
Summary: Multi-specific antibodies (msAbs) are being developed as next generation antibody-based therapeutics. In this study, the biophysical and structural characterization of a bispecific antibody complex in the full antibody context was presented. The study provides insights into the binding interface and validates a new strategy for the structural study of msAbs.
SCIENTIFIC REPORTS
(2023)
Article
Biophysics
Louise Pinet, Ying-Hui Wang, Celia Deville, Ewen Lescop, Francoise Guerlesquin, Ali Badache, Francois Bontems, Nelly Morellet, Dominique Durand, Nadine Assrir, Carine van Heijenoort
Summary: ErbB2, a receptor tyrosine kinase overexpressed in some breast cancers, has been studied for its structure and function, particularly the disordered C-terminal cytoplasmic tail. The presence of transient structural elements suggests potential functional roles in ErbB2's autoregulation processes, providing new insights for mechanistic understanding.
BIOPHYSICAL JOURNAL
(2021)
Article
Oncology
David R. Tong, Wen Zhou, Chen Katz, Kausik Regunath, Divya Venkatesh, Chinyere Ihuegbu, James J. Manfredi, Oleg Laptenko, Carol Prives
Summary: p53 mutations commonly lead to loss of transcriptional activity in cancer, with some variants retaining DNA-binding domains but losing transcriptional activity, and resulting in C-terminally truncated proteins.
MOLECULAR CANCER RESEARCH
(2021)
Article
Plant Sciences
Carolyn J. Schultz, Yue Wu, Ute Baumann
Summary: Diversity in arbuscular mycorrhizal fungi (AMF) contributes to biodiversity and resilience in natural environments and healthy agricultural systems. This study developed a bioinformatics approach to identify highly variable intrinsically disordered proteins (IDPs) in AMF and proposed that these IDPs may play a crucial role in functional complementarity within AMF.
Article
Biophysics
Mohaddeseh Peyro, Mohammad Soheilypour, Vikrum S. Nibber, Andrew M. Dickson, Mohammad R. K. Mofrad
Summary: FG Nups, as intrinsically disordered proteins, possess unique characteristics known as lpLCRs, which are crucial for nucleocytoplasmic transport and distinguish them from other disordered proteins.
BIOPHYSICAL JOURNAL
(2021)
Article
Multidisciplinary Sciences
Marco A. Alfonzo-Mendez, Kem A. Sochacki, Marie-Paule Strub, Justin W. Taraska
Summary: The study reveals the interaction between growth factor signaling and cell adhesion, and highlights the role of flat clathrin lattices in enhancing signal transduction.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Douglas S. MacPherson, Dobeen Hwang, Samantha M. Sarrett, Outi Keinanen, Cindy Rodriguez, Christoph Rader, Brian M. Zeglis
Summary: This study presents a novel solution for site-specific bioconjugation using dual-variable domain immunoglobulins (DVD-IgG). The results suggest that DVD-IgGs could serve as a viable platform for the development of highly effective site-specific radioimmunoconjugates.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Ashmalina Rahman, Owais Ahmed Malik, Mohammad Mansoob Khan
Summary: This study examined the antioxidant activities of green-synthesized pure zinc oxide and doped zinc oxide using aqueous leaf extract of Ziziphus mauritiana. Machine learning models were used to accurately predict the photoantioxidant activities based on input variables such as dopants, crystallite size, lighting condition, and antioxidant concentration. The results showed that doping and lighting condition had a significant impact on the photoantioxidant activities of the materials, with Mg doping and lighting condition having the highest weights according to the artificial neural network models.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Yu-Han Lin, Meng-Yun Xu, Chuan-Chih Hsu, Florensia Ariani Damei, Hui-Chun Lee, Wei-Lun Tsai, Cuong V. Hoang, Yin-Ru Chiang, Lay-Sun Ma
Summary: This study reveals the role of fungal PR-1-like proteins in countering plant defense, and how Ustilago maydis utilizes plant proteases to promote fungal virulence.
NATURE COMMUNICATIONS
(2023)
Review
Microbiology
Bibo Li, Yanxiang Zhao
Summary: Trypanosoma brucei regularly switches its major surface antigen to evade host immune response, with telomere and subtelomere structure integrity being crucial for its survival and pathogenesis. Telomere proteins TRF and RAP1, with unique nucleic acid binding activities, play key roles in VSG expression and switching. Targeting TbTRF and TbRAP1's nucleic acid binding activities may serve as a potential therapeutic strategy against T. brucei.
Review
Biochemistry & Molecular Biology
Eva-Maria Thuering, Christian Hartmann, Ysabel A. Schwietzer, Klaus Ebnet
Summary: The development of multicellular organisms relies on cell adhesion molecules (CAMs) that connect cells for tissue formation. The immunoglobulin superfamily (IgSF), one of the largest families of CAMs, plays diverse roles in synapse formation, spermatogenesis, leukocyte-endothelial interactions, and epithelial cell-cell adhesion. TMIGD1, a member of IgSF, regulates various functions in epithelial cells and is crucial for suppressing malignant cell behavior. This article reviews the molecular characteristics of TMIGD1, its interaction with cytoplasmic scaffolding proteins, the regulation of its expression, and its downregulation in colorectal and renal cancers.
