Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

The Potency of Erythropoietin-Mimic Antibodies Correlates Inversely with Affinity

(2014) S. E. Lacy et al.   JOURNAL OF IMMUNOLOGY

Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

(2012) Wolfgang F. Richter et al.   AAPS Journal

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

(2012) Vinay Bhaskar et al.   DIABETES

Intravascular recovery of VWF and FVIII following intraperitoneal injection and differences from intravenous and subcutaneous injection in mice

(2012) Q. SHI et al.   HAEMOPHILIA

Modern haemophilia care

(2012) Erik Berntorp et al.   LANCET

Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies

(2012) Christian Klein et al.   mAbs

Dual targeting strategies with bispecific antibodies

(2012) Roland Kontermann   mAbs

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

(2012) Takehisa Kitazawa et al.   NATURE MEDICINE

Population pharmacokinetics of recombinant factor VIII: the relationships of pharmacokinetics to age and body weight

(2011) S. Bjorkman et al.   BLOOD

Validity of assessing inhibitor development in haemophilia PUPs using registry data: the EUHASS project

(2011) K. FISCHER et al.   HAEMOPHILIA

Survey of current prophylaxis practices and bleeding characteristics of children with severe haemophilia A in US haemophilia treatment centres

(2011) M. V. RAGNI et al.   HAEMOPHILIA

Opalescence of an IgG2 monoclonal antibody solution as it relates to liquid–liquid phase separation

(2011) Bruce D. Mason et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data

(2011) Rong Deng et al.   mAbs

Engineering the variable region of therapeutic IgG antibodies

(2011) Tomoyuki Igawa et al.   mAbs

Anti-Inhibitor Coagulant Complex Prophylaxis in Hemophilia with Inhibitors

(2011) Cindy Leissinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bispecific antibody: a tool for diagnosis and treatment of disease

(2010) S. SONGSIVILAI et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Development of a Two-part Strategy to Identify a Therapeutic Human Bispecific Antibody That Inhibits IgE Receptor Signaling

(2010) Janet Jackman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

T cell epitope: Friend or Foe? Immunogenicity of biologics in context☆

(2009) Constanze A. Weber et al.   ADVANCED DRUG DELIVERY REVIEWS

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Prediction of immunogenicity: in silico paradigms, ex vivo and in vivo correlates

(2008) A DEGROOT et al.   CURRENT OPINION IN PHARMACOLOGY

New assays for monitoring haemophilia treatment

(2008) M. SHIMA et al.   HAEMOPHILIA

Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice

(2008) A. V. Mayorov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA